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Sanjay Reddy

Sanjay Reddy

Professor Department of Veterinary Pathobiology
Contact
SReddy@cvm.tamu.edu
9794580658
TAMU Mailstop: 4467

Research and Scholarly Interests

The long-term goal of my laboratory is to understand the molecular basis of pathogenesis of Marek’s disease virus (MDV), a potent oncogenic herpesvirus that causes T-cell tumors in chickens. MDV codes for a protein (Meq), which shares significant resemblance with the Jun/Fos family of transcriptional factors. We have shown that this gene plays a critical role in latency and transformation of T-lymphocytes. Understanding the basic mechanism of viral pathogenesis will aid in the development of improved vaccine. We are also interested in other important poultry disease like avian influenza.

EDUCATION

  • B.V.Sc., Andhra Pradesh Agricultural University, India, 1986
  • M.S., University of Maryland, 1989
  • Ph.D., University of Maryland, 1994

CREDENTIALS

  • American College of Veterinary Microbiologists, start 1993, Board Certified
  • Infectious Disease
  • Oncology
  • Microbiology
  • Virology
  • upiani B, Lee LF, Reddy SM (2001). Protein-coding content of the sequence of Marek's disease virus serotype 1. CURR TOP MICROBIOL IMMUNOL. 255, 159-90
  • Silva RF, Reddy SM, Lupiani B (2004). Expansion of a unique region in the Marek's disease virus genome occurs concomitantly with attenuation but is not sufficient to cause attenuation. J VIROL. 2, 733-40
  • Gimeno IM, Witter RL, Hunt HD, Reddy SM, Reed WM (2004). Biocharacteristics shared by highly protective vaccines against Marek's disease. AVIAN PATHOL. 1, 59-68
  • Levy AM, Izumiya Y, Brunovskis P, Xia L, Parcells MS, Reddy SM, Lee L, Chen HW, Kung HJ (2003). Characterization of the chromosomal binding sites and dimerization partners of the viral oncoprotein Meq in Marek's disease virus-transformed T cells. J VIROL. 23, 12841-51
  • Lee LE, Witter RL, Reddy SM, Wu P, Yanagida N, Yoshida S (2003). Protection and synergism by recombinant fowl pox vaccines expressing multiple genes from Marek's disease virus. AVIAN DIS. 3, 549-58
  • Reddy SM, Lupiani B, Gimeno IM, Silva RF, Lee LF, Witter RL (2002). Rescue of a pathogenic Marek's disease virus with overlapping cosmid DNAs: use of a pp38 mutant to validate the technology for the study of gene function. PROC NATL ACAD SCI U S A. 10, 7054-9
  • Schumacher D, Tischer BK, Reddy SM, Osterrieder N (2001). Glycoproteins E and I of Marek's disease virus serotype 1 are essential for virus growth in cultured cells. J VIROL. 23, 11307-18
  • Gimeno IM, Witter RL, Hunt HD, Lee LF, Reddy SM, Neumann U (2001). Marek's disease virus infection in the brain: virus replication, cellular infiltration, and major histocompatibility complex antigen expression. VET PATHOL. 5, 491-503
  • Gimeno IM, Witter RL, Hunt HD, Reddy SM, Neumann U (2001). Differential attenuation of the induction by Marek's disease virus of transient paralysis and persistent neurological disease: a model for pathogenesis studies. AVIAN PATHOL. 4, 397-409
  • Miles AM, Reddy SM, Morgan RW (2001). Coinfection of specific-pathogen-free chickens with Marek's disease virus (MDV) and chicken infectious anemia virus: effect of MDV pathotype. AVIAN DIS. 1, 9-18
  • Reddy SM, Witter RL, Gimeno I (2000). Development of a quantitative-competitive polymerase chain reaction assay for serotype 1 Marek's disease virus. AVIAN DIS. 4, 770-5
  • Reddy SM, Sui D, Wu P, Lee L (1999). Identification and structural analysis of a MDV gene encoding a protein kinase. ACTA VIROL. 2-3, 174-80
  • Wang Y, Lupiani B, Reddy SM, Lamont SJ, Zhou H (2014). RNA-seq analysis revealed novel genes and signaling pathway associated with disease resistance to avian influenza virus infection in chickens. POULT SCI. 2, 485-93
  • Wang Y, Brahmakshatriya V, Lupiani B, Reddy S, Okimoto R, Li X, Chiang H, Zhou H (2012). Associations of chicken Mx1 polymorphism with antiviral responses in avian influenza virus infected embryos and broilers. POULT SCI. 12, 3019-24
  • Wang Y, Brahmakshatriya V, Lupiani B, Reddy SM, Soibam B, Benham AL, Gunaratne P, Liu HC, Trakooljul N, Ing N, Okimoto R, Zhou H (2012). Integrated analysis of microRNA expression and mRNA transcriptome in lungs of avian influenza virus infected broilers. BMC GENOMICS. 13, 278
  • Wang L, Qin Z, Pantin-Jackwood M, Faulkner O, Suarez DL, Garcia M, Lupiani B, Reddy SM, Saif YM, Lee CW (2011). Development of DIVA (differentiation of infected from vaccinated animals) vaccines utilizing heterologous NA and NS1 protein strategies for the control of triple reassortant H3N2 influenza in turkeys. VACCINE. 45, 7966-74
  • Brahmakshatriya VR, Lupiani B, Reddy SM (2010). Characterization and evaluation of avian influenza NS1 mutant virus as a potential live and killed DIVA (differentiating between infected and vaccinated animals) vaccine for chickens. VACCINE. 12, 2388-96
  • Wang Y, Brahmakshatriya V, Zhu H, Lupiani B, Reddy SM, Yoon BJ, Gunaratne PH, Kim JH, Chen R, Wang J, Zhou H (2009). Identification of differentially expressed miRNAs in chicken lung and trachea with avian influenza virus infection by a deep sequencing approach. BMC GENOMICS. 10, 512
  • Lupiani B, Reddy SM (2009). The history of avian influenza. COMP IMMUNOL MICROBIOL INFECT DIS. 4, 311-23
  • Reddy SM, Sun A, Khan OA, Lee LF, Lupiani B (2013). Cloning of a very virulent plus, 686 strain of Marek's disease virus as a bacterial artificial chromosome. AVIAN DIS. 57, 469-73
  • Sun A, Lee LF, Khan OA, Heidari M, Zhang H, Lupiani B, Reddy SM (2013). Deletion of Marek's disease virus large subunit of ribonucleotide reductase impairs virus growth in vitro and in vivo. AVIAN DIS. 57, 464-8
  • Lupiani B, Lee LF, Kreager KS, Witter RL, Reddy SM (2013). Insertion of reticuloendotheliosis virus long terminal repeat into the genome of CVI988 strain of Marek's disease virus results in enhanced growth and protection. AVIAN DIS. 57, 427-31
  • Ferro PJ, Khan O, Peterson MJ, Batchuluun D, Reddy SM, Lupiani B (2012). Avian influenza virus surveillance in hunter-harvested waterfowl, Texas coast, September 2009-January 2010. AVIAN DIS. 56, 1006-9
  • Ferro PJ, Khan O, Vuong C, Reddy SM, LaCoste L, Rollins D, Lupiani B (2012). Avian influenza virus investigation in wild bobwhite quail from Texas. AVIAN DIS. 56, 858-60
  • Lupiani B, Mozisek B, Mason PW, Lamichhane C, Reddy SM (2010). Simultaneous detection of avian influenza virus NP and H5 antibodies in chicken sera using a fluorescence microsphere immunoassay. AVIAN DIS. 54, 668-72
  • Suchodolski PF, Izumiya Y, Lupiani B, Ajithdoss DK, Lee LF, Kung HJ, Reddy SM (2010). Both homo and heterodimers of Marek's disease virus encoded Meq protein contribute to transformation of lymphocytes in chickens. VIROLOGY. 2, 312-21
  • Brahmakshatriya V, Lupiani B, Brinlee JL, Cepeda M, Pillai SD, Reddy SM (2009). Preliminary study for evaluation of avian influenza virus inactivation in contaminated poultry products using electron beam irradiation. AVIAN PATHOL. 3, 245-50
  • Watson DS, Reddy SM, Brahmakshatriya V, Lupiani B (2009). A multiplexed immunoassay for detection of antibodies against avian influenza virus. J IMMUNOL METHODS. 2, 123-31
  • Suchodolski PF, Izumiya Y, Lupiani B, Ajithdoss DK, Gilad O, Lee LF, Kung HJ, Reddy SM (2009). Homodimerization of Marek's disease virus-encoded Meq protein is not sufficient for transformation of lymphocytes in chickens. J VIROL. 2, 859-69
  • Lupiani B, Lee LF, Cui X, Gimeno I, Anderson A, Morgan RW, Silva RF, Witter RL, Kung HJ, Reddy SM (2004). Marek's disease virus-encoded Meq gene is involved in transformation of lymphocytes but is dispensable for replication. PROC NATL ACAD SCI U S A. 32, 11815-20
  • Mallipeddi SK, Lupiani B, Samal SK (1996). Mapping the domains on the phosphoprotein of bovine respiratory syncytial virus required for N-P interaction using a two-hybrid system. J GEN VIROL. 77, 1019-23
  • Mallipeddi SK, Samal SK (1993). Analysis of the ovine respiratory syncytial virus (RSV) G glycoprotein gene defines a subgroup of ungulate RSV. J GEN VIROL. 74, 2787-91
  • Mallipeddi SK, Samal SK (1993). Sequence variability of the glycoprotein gene of bovine respiratory syncytial virus. J GEN VIROL. 74, 2001-4
  • Mallipeddi SK, Samal SK (1993). Structural difference in the fusion protein among strains of bovine respiratory syncytial virus. VET MICROBIOL. 3-4, 359-67
  • Mallipeddi SK, Samal SK (1992). Sequence comparison between the phosphoprotein mRNAs of human and bovine respiratory syncytial viruses identifies a divergent domain in the predicted protein. J GEN VIROL. 73, 2441-4
  • Mallipeddi SK, Samal SK, Mohanty SB (1990). Analysis of polypeptides synthesized in bovine respiratory syncytial virus-infected cells. ARCH VIROL. 1-2, 23-36
  • Lee LF, Heidari M, Sun A, Zhang H, Lupiani B, Reddy S (2013). Identification and in vitro characterization of a Marek's disease virus-encoded Ribonucleotide reductase. AVIAN DIS. 2, 178-87
  • Lee LF, Kreager K, Heidari M, Zhang H, Lupiani B, Reddy SM, Fadly A (2013). Properties of a meq-deleted rmd5 Marek's disease vaccine: protection against virulent MDV challenge and induction of lymphoid organ atrophy are simultaneously attenuated by serial passage in vitro. AVIAN DIS. 57, 491-7
  • Kumar P, Dong H, Lenihan D, Gaddamanugu S, Katneni U, Shaikh S, Tavlarides-Hontz P, Reddy SM, Peters W, Parcells MS (2012). Selection of a recombinant Marek's disease virus in vivo through expression of the Marek's EcoRI-Q (Meq)-encoded oncoprotein: characterization of an rMd5-based mutant expressing the Meq of strain RB-1B. AVIAN DIS. 2, 328-40
  • Gimeno IM, Witter RL, Cortes AL, Reddy SM, Pandiri AR (2012). Standardization of a model to study revaccination against Marek's disease under laboratory conditions. AVIAN PATHOL. 1, 59-68
  • Lee LF, Heidari M, Zhang H, Lupiani B, Reddy SM, Fadly A (2012). Cell culture attenuation eliminates rMd5ΔMeq-induced bursal and thymic atrophy and renders the mutant virus as an effective and safe vaccine against Marek's disease. VACCINE. 34, 5151-8
  • Lee LF, Zhang H, Heidari M, Lupiani B, Reddy SM (2011). Evaluation of factors affecting vaccine efficacy of recombinant Marek's disease virus lacking the Meq oncogene in chickens. AVIAN DIS. 2, 172-9
  • Lee LF, Kreager KS, Arango J, Paraguassu A, Beckman B, Zhang H, Fadly A, Lupiani B, Reddy SM (2010). Comparative evaluation of vaccine efficacy of recombinant Marek's disease virus vaccine lacking Meq oncogene in commercial chickens. VACCINE. 5, 1294-9
  • Arumugaswami V, Kumar PM, Konjufca V, Dienglewicz RL, Reddy SM, Parcells MS (2009). Latency of Marek's disease virus (MDV) in a reticuloendotheliosis virus-transformed T-cell line. II: expression of the latent MDV genome. AVIAN DIS. 2, 156-65
  • Arumugaswami V, Kumar PM, Konjufca V, Dienglewicz RL, Reddy SM, Parcells MS (2009). Latency of Marek's disease virus (MDV) in a reticuloendotheliosis virus-transformed T-cell line. I: uptake and structure of the latent MDV genome. AVIAN DIS. 2, 149-55
  • Ajithdoss DK, Reddy SM, Suchodolski PF, Lee LF, Kung HJ, Lupiani B (2009). In vitro characterization of the Meq proteins of Marek's disease virus vaccine strain CVI988. VIRUS RES. 1-2, 57-67
  • Lee LF, Lupiani B, Silva RF, Kung HJ, Reddy SM (2008). Recombinant Marek's disease virus (MDV) lacking the Meq oncogene confers protection against challenge with a very virulent plus strain of MDV. VACCINE. 15, 1887-92
  • Lee LF, Silva RF, Cui X, Zhang H, Heidari M, Reddy SM (2007). Characterization of LORF11, a unique gene common to the three Marek's disease virus serotypes. AVIAN DIS. 4, 851-7
  • Ding J, Cui Z, Lee LF, Cui X, Reddy SM (2006). The role of pp38 in regulation of Marek's disease virus bi-directional promoter between pp38 and 1.8-kb mRNA. VIRUS GENES. 2, 193-201
  • Cui X, Lee LF, Hunt HD, Reed WM, Lupiani B, Reddy SM (2005). A Marek's disease virus vIL-8 deletion mutant has attenuated virulence and confers protection against challenge with a very virulent plus strain. AVIAN DIS. 2, 199-206
  • Lee LF, Cui X, Cui Z, Gimeno I, Lupiani B, Reddy SM (2005). Characterization of a very virulent Marek's disease virus mutant expressing the pp38 protein from the serotype 1 vaccine strain CVI988/Rispens. VIRUS GENES. 1, 73-80
  • Gimeno IM, Witter RL, Hunt HD, Reddy SM, Lee LF, Silva RF (2005). The pp38 gene of Marek's disease virus (MDV) is necessary for cytolytic infection of B cells and maintenance of the transformed state but not for cytolytic infection of the feather follicle epithelium and horizontal spread of MDV. J VIROL. 7, 4545-9
  • Cui X, Lee LF, Reed WM, Kung HJ, Reddy SM (2004). Marek's disease virus-encoded vIL-8 gene is involved in early cytolytic infection but dispensable for establishment of latency. J VIROL. 9, 4753-60
  • Reddy, S.M. and Lupiani, B (2015). Neoplastic diseases of poultry: avian leucosis, reticuloendotheliosis and Marek’s disease XIX WORLD VETERINARY POULTRY ASSOCIATION CONGRESS PROCEEDING.
  • Reddy, S.M. and Lupiani, B. (2016). Marek's disease vaccines: current challenges and future strategies VETERINARY MICROBIOLOGY.

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