Susan Payne
Associate Professor Emerita Department of Veterinary PathobiologyResearch and Scholarly Interests
Molecular aspects of viral replication, pathogenesis, and evolution. The major focus of the laboratory is the retrovirus, equine infectious anemia virus. EIAV studies include evolution of virulence during rapid virus passage, modification of cell signaling pathways mediated by viral glycoproteins, effects of proinflammatory cytokines on virus replication and disease, and detailed mapping of EIAV virulence determinants. We also study the recently discovered avian bornavirus, etiological agent of proventricular dilatation disease of parrots, in conjunction with colleagues from the Schubot center.
EDUCATION
- B.S., University of Massachusetts, 1978
- Ph.D., Louisiana State University, 1983
- Infectious Disease
- Payne S, Delnatte P, Guo J, Heatley JJ, Tizard I, DA Smith (2012). Birds and Bornaviruses ANIMAL HEALTH RESEARCH REVIEWS. 13, 145-156
- Guo J, Payne S, Zhang S, Turner D, Tizard I, Suchodolski P (2014). Avian bornaviruses: diagnosis, isolation and genotyping CURRENT PROTOCOLS IN MICROBIOLOGY. 34, 1
- Villanueva I, Gray P, Mirhosseini N, Payne S, Hoppes S, Honkavuori KS, Briese T, Turner D, Tizard I (2010). The diagnosis of proventricular dilatation disease: use of a Western blot assay to detect antibodies against avian Borna virus. VET MICROBIOL. 2-4, 196-201
- Guo J, Covaleda L, Heatley JJ, Baroch, J, Tizard I, Payne S (2012). Widespread avian bornavirus infection in mute swans in the northeast United States VETERINARY MEDICINE: RESEARCH AND REPORTS. 3, 49-52
- Mirhosseini N, Gray PL, Hoppes S, Tizard I, Shivaprasad HL, Payne S (2011). Proventricular dilatation disease in cockatiels (Nymphicus hollandicus) after infection with a genotype 2 avian bornavirus. J AVIAN MED SURG. 3, 199-204
- Payne S, Covaleda L, Jianhua G, Swafford S, Baroch J, Ferro PJ, Lupiani B, Heatley J, Tizard I (2011). Detection and characterization of a distinct bornavirus lineage from healthy Canada geese (Branta canadensis). J VIROL. 22, 12053-6
- Covaleda L, Gno BT, Fuller FJ, Payne SL (2010). Identification of cellular proteins interacting with equine infectious anemia virus S2 protein. VIRUS RES. 2, 235-9
- Payne SL, Fuller FJ (2010). Virulence determinants of equine infectious anemia virus. CURR HIV RES. 1, 66-72
- Covaleda L, Fuller FJ, Payne SL (2010). EIAV S2 enhances pro-inflammatory cytokine and chemokine response in infected macrophages. VIROLOGY. 1, 217-23
- Ouyang N, Storts R, Tian Y, Wigle W, Villanueva I, Mirhosseini N, Payne S, Gray P, Tizard I (2009). Histopathology and the detection of avian bornavirus in the nervous system of birds diagnosed with proventricular dilatation disease. AVIAN PATHOL. 5, 393-401
- Nerren JR, Martens RJ, Payne S, Murrell J, Butler JL, Cohen ND (2009). Age-related changes in cytokine expression by neutrophils of foals stimulated with virulent Rhodococcus equi in vitro. VET IMMUNOL IMMUNOPATHOL. 3-4, 212-9
- Nerren JR, Payne S, Halbert ND, Martens RJ, Cohen ND (2009). Cytokine expression by neutrophils of adult horses stimulated with virulent and avirulent Rhodococcus equi in vitro. VET IMMUNOL IMMUNOPATHOL. 1-2, 135-43
- Allen CA, Payne SL, Harville M, Cohen N, Russell KE (2007). Validation of quantitative polymerase chain reaction assays for measuring cytokine expression in equine macrophages. J IMMUNOL METHODS. 1-2, 59-69
- Ball JM, Swaggerty CL, Pei X, Lim WS, Xu X, Cox VC, Payne SL (2005). SU proteins from virulent and avirulent EIAV demonstrate distinct biological properties. VIROLOGY. 1, 132-44
- Payne SL, Pei XF, Jia B, Fagerness A, Fuller FJ (2004). Influence of long terminal repeat and env on the virulence phenotype of equine infectious anemia virus. J VIROL. 5, 2478-85
- Lim WS, Edwards JF, Boyd NK, Payne SL, Ball JM (2003). Simultaneous quantitation of equine cytokine mRNAs using a multi-probe ribonuclease protection assay. VET IMMUNOL IMMUNOPATHOL. 1, 45-51
- Mirhosseini N, Gray PL, Tizard I, Payne S (2012). Complete genome sequence of avian bornavirus genotype 1 from a Macaw with proventricular dilatation disease. J VIROL. 12, 7023
- Payne S, Shivaprasad HL, Mirhosseini N, Gray P, Hoppes S, Weissenbock H, Tizard I (2011). Unusual and severe lesions of proventricular dilatation disease in cockatiels (Nymphicus hollandicus) acting as healthy carriers of avian bornavirus (ABV) and subsequently infected with a virulent strain of ABV. AVIAN PATHOL. 1, 15-22
- Hoppes S, Gray PL, Payne S, Shivaprasad HL, Tizard I (2010). The isolation, pathogenesis, diagnosis, transmission, and control of avian bornavirus and proventricular dilatation disease. VET CLIN NORTH AM EXOT ANIM PRACT. 3, 495-508
- Gray P, Hoppes S, Suchodolski P, Mirhosseini N, Payne S, Villanueva I, Shivaprasad HL, Honkavuori KS, Lipkin WI, Briese T, Reddy SM, Tizard I (2010). Use of avian bornavirus isolates to induce proventricular dilatation disease in conures. EMERG INFECT DIS. 3, 473-9
- Diana T Cervantes*, Judith M Ball, John Edwards, Susan Payne (2016). Horses naturally infected with EIAV harbor 2 distinct SU populations but are monophyletic with respect to IN. VIRUS GENES.
- Ian Tizard, Judith Ball, George Stoica, Susan Payne (2016). The pathogenesis of bornaviral diseases in mammals. ANIMAL HEALTH RESEARCH REVIEWS.
- Jianhua Guo, Ian Tizard, John Baroch, H L Shivaprasad, Susan L Payne (2015). Avian Bornaviruses in North American Gulls. JOURNAL OF WILDLIFE DISEASES. 3, 754-8
- Claudio L Afonso, Gaya K Amarasinghe, Krisztián Bányai, Yīmíng Bào, Christopher F Basler, Sina Bavari, Nicolás Bejerman, Kim R Blasdell, François-Xavier Briand, Thomas Briese, Alexander Bukreyev, Charles H Calisher, Kartik Chandran, Jiāsēn Chéng, Anna N Clawson, Peter L Collins, Ralf G Dietzgen, Olga Dolnik, Leslie L Domier, Ralf Dürrwald, John M Dye, Andrew J Easton, Hideki Ebihara, Szilvia L Farkas, Juliana Freitas-Astúa, Pierre Formenty, Ron A M Fouchier, Yànpíng Fù, Elodie Ghedin, Michael M Goodin, Roger Hewson, Masayuki Horie, Timothy H Hyndman, Dàohóng Jiāng, Elliot W Kitajima, Gary P Kobinger, Hideki Kondo, Gael Kurath, Robert A Lamb, Sergio Lenardon, Eric M Leroy, Ci-Xiu Li, Xian-Dan Lin, Lìjiāng Liú, Ben Longdon, Szilvia Marton, Andrea Maisner, Elke Mühlberger, Sergey V Netesov, Norbert Nowotny, Jean L Patterson, Susan L Payne, Janusz T Paweska, Rick E Randall, Bertus K Rima, Paul Rota, Dennis Rubbenstroth, Martin Schwemmle, Mang Shi, Sophie J Smither, Mark D Stenglein, David M Stone, Ayato Takada, Calogero Terregino, Robert B Tesh, Jun-Hua Tian, Keizo Tomonaga, Noël Tordo, Jonathan S Towner, Nikos Vasilakis, Martin Verbeek, Viktor E Volchkov, Victoria Wahl-Jensen, John A Walsh, Peter J Walker, David Wang, Lin-Fa Wang, Thierry Wetzel, Anna E Whitfield, Ji Tāo Xiè, Kwok-Yung Yuen, Yong-Zhen Zhang, Jens H Kuhn (2016). Taxonomy of the order Mononegavirales: update 2016. ARCHIVES OF VIROLOGY.
- Guo J, Shivaprasad HL, Rech RR, Heatley JJ, Tizard I, Payne S (2014). Characterization of a new genotype of avian bornavirus from wild ducks. VIROL J. 11, 197
- Thomas S Postler, Anna N Clawson, Gaya K Amarasinghe, Christopher F Basler, Sbina Bavari, Mária Benko, Kim R Blasdell, Thomas Briese, Michael J Buchmeier, Alexander Bukreyev, Charles H Calisher, Kartik Chandran, Rémi Charrel, Christopher S Clegg, Peter L Collins, De La Torre Juan Carlos, Joseph L Derisi, Ralf G Dietzgen, Olga Dolnik, Ralf Dürrwald, John M Dye, Andrew J Easton, Sébastian Emonet, Pierre Formenty, Ron A M Fouchier, Elodie Ghedin, Jean-Paul Gonzalez, Balázs Harrach, Roger Hewson, Masayuki Horie, Dàohóng Jiang, Gary Kobinger, Hideki Kondo, Andrew M Kropinski, Mart Krupovic, Gael Kurath, Robert A Lamb, Eric M Leroy, Igor S Lukashevich, Andrea Maisner, Arcady R Mushegian, Sergey V Netesov, Norbert Nowotny, Jean L Patterson, Susan L Payne, Janusz T PaWeska, Clarence J Peters, Sheli R Radoshitzky, Bertus K Rima, Victor Romanowski, Dennis Rubbenstroth, Sead Sabanadzovic, Hélène Sanfaçon, Maria S Salvato, Martin Schwemmle, Sophie J Smither, Mark D Stenglein, David M Stone, Ayato Takada, Robert B Tesh, Keizo Tomonaga, Noël Tordo, Jonathan S Towner, Nikos Vasilakis, Viktor E Volchkov, Victoria Wahl-Jensen, Peter J Walker, Lin-Fa Wang, Arvind Varsani, Anna E Whitfield, F Murilo Zerbini, Jens H Kuhn (2016). Possibility and Challenges of Conversion of Current Virus Species Names to Linnaean Binomials. SYSTEMATIC BIOLOGY. 3, 463-473
- Murray, O, Turner, D, Streeter, K, Guo, J, Shivaprasad, HL, Payne, S, Tizard I. (2017). Apparent resolution of parrot bornavirus infection in cockatiels (Nymphicus hollandicus) VETERINARY MEDICINE: RESEARCH AND REPORTS., 31-36