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Ian Tizard

Ian Tizard

Distinguished Professor Department of Veterinary Pathobiology
Contact
Schubot Exotic Bird Health Center
ITIZARD@cvm.tamu.edu
9798454276
TAMU Mailstop: 4467

Research and Scholarly Interests

Immunology with an emphasis on innovative vaccine technology and on the immunology of domestic mammals.Avian diseases with an emphasis on diseases of psittacinesPaleovirology,Genomics with an emphasis on whole avian genomes.The intestinal microbiome and its role in immunity.

EDUCATION

  • B.V.M.& S., University of Edinburgh, Scotland, UK, 1965
  • B.Sc., University of Edinburgh, Scotland, UK, 1966
  • Ph.D., University of Cambridge, England, 1969

CREDENTIALS

  • ACVM (Honorary)
  • DSc (Honorary). University of Guelph, start 2012
  • Immunology
  • Neuroscience
  • Genomics
  • Infectious Disease
  • Virology
  • Zoo, Exotic and Wildlife Medicine
  • Avian Medicine
  • Mirhosseini N, Gray PL, Hoppes S, Tizard I, Shivaprasad HL, Payne S (2011). Proventricular dilatation disease in cockatiels (Nymphicus hollandicus) after infection with a genotype 2 avian bornavirus. J AVIAN MED SURG. 3, 199-204
  • Payne S, Covaleda L, Jianhua G, Swafford S, Baroch J, Ferro PJ, Lupiani B, Heatley J, Tizard I (2011). Detection and characterization of a distinct bornavirus lineage from healthy Canada geese (Branta canadensis). J VIROL. 22, 12053-6
  • Payne S, Covaleda L, Jianhua G, Swafford S, Baroch J, Ferro PJ, Lupiani B, Heatley J, Tizard I (2011). Detection and Characterization of a Distinct Bornavirus Lineage from Healthy Canada Geese (Branta canadensis). J VIROL.
  • Saggese MD, Tizard I, Phalen DN (2010). Comparison of sampling methods, culture, acid-fast stain, and polymerase chain reaction assay for the diagnosis of mycobacteriosis in ring-neck doves (Streptopelia risoria). J AVIAN MED SURG. 4, 263-71
  • Xenoulis PG, Gray PL, Brightsmith D, Palculict B, Hoppes S, Steiner JM, Tizard I, Suchodolski JS (2010). Molecular characterization of the cloacal microbiota of wild and captive parrots. VET MICROBIOL. 3-4, 320-5
  • Ouyang N, Storts R, Tian Y, Wigle W, Villanueva I, Mirhosseini N, Payne S, Gray P, Tizard I (2009). Histopathology and the detection of avian bornavirus in the nervous system of birds diagnosed with proventricular dilatation disease. AVIAN PATHOL. 5, 393-401
  • Musser JM, Taylor CA, Guo J, Tizard IR, Walker JW (2008). Development of a contagious ecthyma vaccine for goats. AM J VET RES. 10, 1366-70
  • Gray PL, Saggese MD, Phalen DN, Tizard I (2008). Humoral response to Mycobacterium avium subsp. avium in naturally infected ring-neck doves (Streptopelia risoria). VET IMMUNOL IMMUNOPATHOL. 3-4, 216-24
  • Saggese MD, Tizard I, Phalen DN (2008). Mycobacteriosis in naturally infected ring-neck doves (Streptopelia risoria): investigation of the association between feather colour and susceptibility to infection, disease and lesions type. AVIAN PATHOL. 4, 443-50
  • Tizard I (2008). Sickness behavior, its mechanisms and significance. ANIM HEALTH RES REV. 1, 87-99
  • Ni Y, Turner D, Yates KM, Tizard I (2004). Isolation and characterization of structural components of Aloe vera L. leaf pulp. INT IMMUNOPHARMACOL. 14, 1745-55
  • Higgins SE, Berghman LR, Moore RW, Caldwell DJ, Caldwell DY, Tizard I, Hargis BM (2002). In situ detection and quantification of bursa of fabricius cellular proliferation or apoptosis in normal or steroid-treated neonatal chicks. POULT SCI. 8, 1136-41
  • Tizard I (2001). The protective properties of milk and colostrum in non-human species. ADV NUTR RES. 10, 139-66
  • Srinivasan A, Ni Y, Tizard I (1999). Specificity and prevalence of natural bovine antimannan antibodies. CLIN DIAGN LAB IMMUNOL. 6, 946-52
  • Tizard I (1999). Grease, anthraxgate, and kennel cough: a revisionist history of early veterinary vaccines. ADV VET MED. 41, 7-24
  • Tizard I, Ni Y (1998). Use of serologic testing to assess immune status of companion animals. J AM VET MED ASSOC. 1, 54-60
  • Ramamoorthy L, Tizard IR (1998). Induction of apoptosis in a macrophage cell line RAW 264.7 by acemannan, a beta-(1,4)-acetylated mannan. MOL PHARMACOL. 3, 415-21
  • Zhang L, Tizard IR (1996). Activation of a mouse macrophage cell line by acemannan: the major carbohydrate fraction from Aloe vera gel. IMMUNOPHARMACOLOGY. 2, 119-28
  • Ramamoorthy L, Kemp MC, Tizard IR (1996). Acemannan, a beta-(1,4)-acetylated mannan, induces nitric oxide production in macrophage cell line RAW 264.7. MOL PHARMACOL. 4, 878-84
  • Chinnah AD, Baig MA, Tizard IR, Kemp MC (1992). Antigen dependent adjuvant activity of a polydispersed beta-(1,4)-linked acetylated mannan (acemannan). VACCINE. 8, 551-7
  • Tizard I (1991). Use of immunomodulators as an aid to clinical management of feline leukemia virus-infected cats. J AM VET MED ASSOC. 10, 1482-5
  • Tizard I, Bass EP (1991). Evaluation of a killed, whole virion feline leukemia virus vaccine. J AM VET MED ASSOC. 10, 1410-3
  • Tizard I (1990). Risks associated with use of live vaccines. J AM VET MED ASSOC. 11, 1851-8
  • Tizard IR, Carpenter RH, McAnalley BH, Kemp MC (1989). The biological activities of mannans and related complex carbohydrates. MOL BIOTHER. 6, 290-6
  • Bannister R, Davis D, Zacharewski T, Tizard I, Safe S (1987). Aroclor 1254 as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: effects on enzyme induction and immunotoxicity. TOXICOLOGY. 1, 29-42
  • Zhang L, Tizard IR (1996). Activation of a mouse macrophage cell line by acemannan: the major carbohydrate fraction from Aloe vera gel. IMMUNOPHARMACOLOGY. 2, 119-28
  • Ramamoorthy L, Kemp MC, Tizard IR (1996). Acemannan, a beta-(1,4)-acetylated mannan, induces nitric oxide production in macrophage cell line RAW 264.7. MOL PHARMACOL. 4, 878-84
  • Chinnah AD, Baig MA, Tizard IR, Kemp MC (1992). Antigen dependent adjuvant activity of a polydispersed beta-(1,4)-linked acetylated mannan (acemannan). VACCINE. 8, 551-7
  • Bannister R, Davis D, Zacharewski T, Tizard I, Safe S (1987). Aroclor 1254 as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: effects on enzyme induction and immunotoxicity. TOXICOLOGY. 1, 29-42
  • Musser JM, Taylor CA, Guo J, Tizard IR, Walker JW (2008). Development of a contagious ecthyma vaccine for goats. AM J VET RES. 10, 1366-70
  • Daugette KF, Hoppes S, Tizard I, Brightsmith D (2012). Positive reinforcement training facilitates the voluntary participation of laboratory macaws with veterinary procedures. J AVIAN MED SURG. 4, 248-54
  • Mirhosseini N, Gray PL, Hoppes S, Tizard I, Shivaprasad HL, Payne S (2011). Proventricular dilatation disease in cockatiels (Nymphicus hollandicus) after infection with a genotype 2 avian bornavirus. J AVIAN MED SURG. 3, 199-204
  • Payne S, Covaleda L, Jianhua G, Swafford S, Baroch J, Ferro PJ, Lupiani B, Heatley J, Tizard I (2011). Detection and characterization of a distinct bornavirus lineage from healthy Canada geese (Branta canadensis). J VIROL. 22, 12053-6
  • Saggese MD, Tizard I, Phalen DN (2010). Comparison of sampling methods, culture, acid-fast stain, and polymerase chain reaction assay for the diagnosis of mycobacteriosis in ring-neck doves (Streptopelia risoria). J AVIAN MED SURG. 4, 263-71
  • Xenoulis PG, Gray PL, Brightsmith D, Palculict B, Hoppes S, Steiner JM, Tizard I, Suchodolski JS (2010). Molecular characterization of the cloacal microbiota of wild and captive parrots. VET MICROBIOL. 3-4, 320-5
  • Tizard I (2008). Sickness behavior, its mechanisms and significance. ANIM HEALTH RES REV. 1, 87-99
  • Tizard I (2001). The protective properties of milk and colostrum in non-human species. ADV NUTR RES. 10, 139-66
  • Payne SL, Delnatte P, Guo J, Heatley JJ, Tizard I, Smith DA (2012). Birds and bornaviruses. ANIM HEALTH RES REV. 2, 145-56
  • Tizard I (1999). Grease, anthraxgate, and kennel cough: a revisionist history of early veterinary vaccines. ADV VET MED. 41, 7-24
  • Tizard I, Ni Y (1998). Use of serologic testing to assess immune status of companion animals. J AM VET MED ASSOC. 1, 54-60
  • Ramamoorthy L, Tizard IR (1998). Induction of apoptosis in a macrophage cell line RAW 264.7 by acemannan, a beta-(1,4)-acetylated mannan. MOL PHARMACOL. 3, 415-21
  • Ouyang N, Storts R, Tian Y, Wigle W, Villanueva I, Mirhosseini N, Payne S, Gray P, Tizard I (2009). Histopathology and the detection of avian bornavirus in the nervous system of birds diagnosed with proventricular dilatation disease. AVIAN PATHOL. 5, 393-401
  • Gray PL, Saggese MD, Phalen DN, Tizard I (2008). Humoral response to Mycobacterium avium subsp. avium in naturally infected ring-neck doves (Streptopelia risoria). VET IMMUNOL IMMUNOPATHOL. 3-4, 216-24
  • Saggese MD, Tizard I, Phalen DN (2008). Mycobacteriosis in naturally infected ring-neck doves (Streptopelia risoria): investigation of the association between feather colour and susceptibility to infection, disease and lesions type. AVIAN PATHOL. 4, 443-50
  • Higgins SE, Berghman LR, Moore RW, Caldwell DJ, Caldwell DY, Tizard I, Hargis BM (2002). In situ detection and quantification of bursa of fabricius cellular proliferation or apoptosis in normal or steroid-treated neonatal chicks. POULT SCI. 8, 1136-41
  • Tizard IR, Carpenter RH, McAnalley BH, Kemp MC (1989). The biological activities of mannans and related complex carbohydrates. MOL BIOTHER. 6, 290-6
  • Tizard I, Bass EP (1991). Evaluation of a killed, whole virion feline leukemia virus vaccine. J AM VET MED ASSOC. 10, 1410-3
  • Guo J, Shivaprasad HL, Rech RR, Heatley JJ, Tizard I, Payne S (2014). Characterization of a new genotype of avian bornavirus from wild ducks. VIROL J. 1, 197
  • Guo J, Payne S, Zhang S, Turner D, Tizard I, Suchodolski P (2014). Avian bornaviruses: diagnosis, isolation, and genotyping. CURR PROTOC MICROBIOL. 34, 15
  • Halley YA, Dowd SE, Decker JE, Seabury PM, Bhattarai E, Johnson CD, Rollins D, Tizard IR, Brightsmith DJ, Peterson MJ, Taylor JF, Seabury CM (2014). A draft de novo genome assembly for the northern bobwhite (Colinus virginianus) reveals evidence for a rapid decline in effective population size beginning in the Late Pleistocene. PLOS ONE. 3,
  • Guo J, Baroch J, Randall A, Tizard I (2013). Complete Genome Sequence of an Avian Bornavirus Isolated from a Healthy Canadian Goose (Branta canadensis). GENOME ANNOUNC. 5,
  • Seabury CM, Dowd SE, Seabury PM, Raudsepp T, Brightsmith DJ, Liboriussen P, Halley Y, Fisher CA, Owens E, Viswanathan G, Tizard IR (2013). A multi-platform draft de novo genome assembly and comparative analysis for the Scarlet Macaw (Ara macao). PLOS ONE. 5,
  • Mashoof S, Goodroe A, Du CC, Eubanks JO, Jacobs N, Steiner JM, Tizard I, Suchodolski JS, Criscitiello MF (2013). Ancient T-independence of mucosal IgX/A: gut microbiota unaffected by larval thymectomy in Xenopus laevis. MUCOSAL IMMUNOL. 2, 358-68
  • Hayden CA, Streatfield SJ, Lamphear BJ, Fake GM, Keener TK, Walker JH, Clements JD, Turner DD, Tizard IR, Howard JA (2012). Bioencapsulation of the hepatitis B surface antigen and its use as an effective oral immunogen. VACCINE. 19, 2937-42
  • Velasquez LS, Shira S, Berta AN, Kilbourne J, Medi BM, Tizard I, Ni Y, Arntzen CJ, Herbst-Kralovetz MM (2011). Intranasal delivery of Norwalk virus-like particles formulated in an in situ gelling, dry powder vaccine. VACCINE. 32, 5221-31
  • Villanueva I, Gray P, Mirhosseini N, Payne S, Hoppes S, Honkavuori KS, Briese T, Turner D, Tizard I (2010). The diagnosis of proventricular dilatation disease: use of a Western blot assay to detect antibodies against avian Borna virus. VET MICROBIOL. 2-4, 196-201
  • Ni Y, Turner D, Yates K, Tizard I (2007). Stabilization of growth factors relevant to wound healing by a plant cell wall biomaterial. PLANTA MED. 12, 1260-6
  • Hayden CA, Smith EM, Turner DD, Keener TK, Wong JC, Walker JH, Tizard IR, Jimenez-Flores R, Howard JA (2014). Supercritical fluid extraction provides an enhancement to the immune response for orally-delivered hepatitis B surface antigen. VACCINE. 11, 1240-6
  • Ni Y, Turner D, Yates KM, Tizard I (2004). Isolation and characterization of structural components of Aloe vera L. leaf pulp. INT IMMUNOPHARMACOL. 14, 1745-55
  • Srinivasan A, Ni Y, Tizard I (1999). Specificity and prevalence of natural bovine antimannan antibodies. CLIN DIAGN LAB IMMUNOL. 6, 946-52
  • Tizard I (1991). Use of immunomodulators as an aid to clinical management of feline leukemia virus-infected cats. J AM VET MED ASSOC. 10, 1482-5
  • Tizard I (1990). Risks associated with use of live vaccines. J AM VET MED ASSOC. 11, 1851-8
  • Hoppes SM, Tizard I, Shivaprasad HL (2013). Avian bornavirus and proventricular dilatation disease: diagnostics, pathology, prevalence, and control. VET CLIN NORTH AM EXOT ANIM PRACT. 2, 339-55
  • Ian Tizard, Judith Ball, George Stoica, Susan Payne (2016). The pathogenesis of bornaviral diseases in mammals. ANIMAL HEALTH RESEARCH REVIEWS / CONFERENCE OF RESEARCH WORKERS IN ANIMAL DISEASES., 1-18
  • Cassandra Seibold-Torres, Elaine Owens, Renuka Chowdhary, Malcolm A Ferguson-Smith, Ian Tizard, Terje Raudsepp (2016). Comparative Cytogenetics of the Congo African Grey Parrot (Psittacus erithacus). CYTOGENETIC AND GENOME RESEARCH. 2-3, 144-53
  • Jianhua Guo, Ian Tizard (2015). The genome sequence of parrot bornavirus 5. VIRUS GENES. 3, 430-3
  • Jeffrey M B Musser, J Jill Heatley, Anastasia V Koinis, Paulette F Suchodolski, Jianhua Guo, Paulina Escandon, Ian R Tizard (2015). Ribavirin Inhibits Parrot Bornavirus 4 Replication in Cell Culture. PLOS ONE. 7,
  • Jianhua Guo, Ian Tizard, John Baroch, H L Shivaprasad, Susan L Payne (2015). Avian Bornaviruses in North American Gulls. JOURNAL OF WILDLIFE DISEASES. 3, 754-8
  • Celine A Hayden, Maria E Fischer, Bryan L Andrews, Hayley C Chilton, Debra D Turner, John H Walker, Ian R Tizard, John A Howard (2015). Oral delivery of wafers made from HBsAg-expressing maize germ induces long-term immunological systemic and mucosal responses. VACCINE. 25, 2881-6

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