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Loren Skow

Loren Skow

Senior Professor Department of Veterinary Integrative Biosciences
Contact
Lskow@cvm.tamu.edu
9798453194
TAMU Mailstop: 4458

Research and Scholarly Interests

Comparative genomics of mammals with emphasis on organization and evolution of the mammalian genome; molecular analysis of the major histocompatibility complex of hoofed animals; genetic mechanisms of inherent resistance to infectious diseases.

EDUCATION

  • B.S., Abilene Christian University, 1968
  • M.S., Abilene Christian University, 1970
  • Ph.D., Texas A&M University, 1976
  • Immunology
  • Genomics
  • Genetics
  • Infectious Disease
  • Beamer WG, Tennent BJ, Shultz KL, Nadeau JH, Shultz LD, Skow LC (1988). Gene for ovarian granulosa cell tumor susceptibility, Gct, in SWXJ recombinant inbred strains of mice revealed by dehydroepiandrosterone. CANCER RES. 18, 5092-5
  • Skow LC, Nadeau JN, Ahn JC, Shin HS, Artzt K, Bennett D (1987). Polymorphism and linkage of the alpha A-crystallin gene in t-haplotypes of the mouse. GENETICS. 1, 107-11
  • Skow LC, Donner ME, Popp RA, Bailiff EG (1985). A second polymorphic lens crystallin (LEN-2) in the mouse: genetic and biochemical analysis of LEN-1 and LEN-2. BIOCHEM GENET. 1-2, 181-9
  • Whitney JB 3rd, Copland GT, Skow LC, Russell ES (1979). Resolution of products of the duplicated hemoglobin alpha-chain loci by isoelectric focusing. PROC NATL ACAD SCI U S A. 2, 867-71
  • Skow LC (1981). Genetic variation for prolidase (PEP-4) in the mouse maps near the gene for glucosephosphate isomerase (GPI-1) on chromosome 7. BIOCHEM GENET. 7-8, 695-700
  • Popp RA, Marsh CL, Skow LC (1981). Expression of embryonic hemoglobin genes in mice heterozygous for alpha-thalassemia or beta-duplication traits and in mice heterozygous for both traits. DEV BIOL. 1, 123-8
  • Popp RA, Bradshaw BS, Skow LC (1980). Effects of alpha thalassemia on mouse development. DIFFERENTIATION. 3, 205-10
  • Popp RA, Skow LC, Whitney JB 3rd (1980). Expression of embryonic hemoglobin genes in alpha-thalassemic and in beta-duplication mice. ANN N Y ACAD SCI. 344, 280-3
  • Grosz MD, Womack JE, Skow LC (1992). Syntenic conservation of HSP70 genes in cattle and humans. GENOMICS. 4, 863-8
  • Brinkmeyer-Langford CL, Murphy WJ, Childers CP, Skow LC (2010). A conserved segmental duplication within ELA. ANIM GENET. Suppl 2, 186-95
  • Brinkmeyer-Langford CL, Childers CP, Fritz KL, Gustafson-Seabury AL, Cothran M, Raudsepp T, Womack JE, Skow LC (2009). A high resolution RH map of the bovine major histocompatibility complex. BMC GENOMICS. 10, 182
  • Raudsepp T, Gustafson-Seabury A, Durkin K, Wagner ML, Goh G, Seabury CM, Brinkmeyer-Langford C, Lee EJ, Agarwala R, Stallknecht-Rice E, Schäffer AA, Skow LC, Tozaki T, Yasue H, Penedo MC, Lyons LA, Khazanehdari KA, Binns MM, MacLeod JN, Distl O, Guérin G, Leeb T, Mickelson JR, Chowdhary BP (2008). A 4,103 marker integrated physical and comparative map of the horse genome. CYTOGENET GENOME RES. 1, 28-36
  • Pearks Wilkerson AJ, Raudsepp T, Graves T, Albracht D, Warren W, Chowdhary BP, Skow LC, Murphy WJ (2008). Gene discovery and comparative analysis of X-degenerate genes from the domestic cat Y chromosome. GENOMICS. 5, 329-38
  • Childers CP, Newkirk HL, Honeycutt DA, Ramlachan N, Muzney DM, Sodergren E, Gibbs RA, Weinstock GM, Womack JE, Skow LC (2006). Comparative analysis of the bovine MHC class IIb sequence identifies inversion breakpoints and three unexpected genes. ANIM GENET. 2, 121-9
  • Brinkmeyer-Langford C, Raudsepp T, Lee EJ, Goh G, Schäffer AA, Agarwala R, Wagner ML, Tozaki T, Skow LC, Womack JE, Mickelson JR, Chowdhary BP (2005). A high-resolution physical map of equine homologs of HSA19 shows divergent evolution compared with other mammals. MAMM GENOME. 8, 631-49
  • Murphy WJ, Larkin DM, Everts-van der Wind A, Bourque G, Tesler G, Auvil L, Beever JE, Chowdhary BP, Galibert F, Gatzke L, Hitte C, Meyers SN, Milan D, Ostrander EA, Pape G, Parker HG, Raudsepp T, Rogatcheva MB, Schook LB, Skow LC, Welge M, Womack JE, O'brien SJ, Pevzner PA, Lewin HA (2005). Dynamics of mammalian chromosome evolution inferred from multispecies comparative maps. SCIENCE. 5734, 613-7
  • Gustafson-Seabury A, Raudsepp T, Goh G, Kata SR, Wagner ML, Tozaki T, Mickelson JR, Womack JE, Skow LC, Chowdhary BP (2005). High-resolution RH map of horse chromosome 22 reveals a putative ancestral vertebrate chromosome. GENOMICS. 2, 188-200
  • Raudsepp T, Santani A, Wallner B, Kata SR, Ren C, Zhang HB, Womack JE, Skow LC, Chowdhary BP (2004). A detailed physical map of the horse Y chromosome. PROC NATL ACAD SCI U S A. 25, 9321-6
  • Raudsepp T, Lee EJ, Kata SR, Brinkmeyer C, Mickelson JR, Skow LC, Womack JE, Chowdhary BP (2004). Exceptional conservation of horse-human gene order on X chromosome revealed by high-resolution radiation hybrid mapping. PROC NATL ACAD SCI U S A. 8, 2386-91
  • Gustafson AL, Tallmadge RL, Ramlachan N, Miller D, Bird H, Antczak DF, Raudsepp T, Chowdhary BP, Skow LC (2003). An ordered BAC contig map of the equine major histocompatibility complex. CYTOGENET GENOME RES. 1-4, 189-95
  • Lee EJ, Raudsepp T, Kata SR, Adelson D, Womack JE, Skow LC, Chowdhary BP (2004). A 1.4-Mb interval RH map of horse chromosome 17 provides detailed comparison with human and mouse homologues. GENOMICS. 2, 203-15
  • Chowdhary BP, Raudsepp T, Kata SR, Goh G, Millon LV, Allan V, Piumi F, Guérin G, Swinburne J, Binns M, Lear TL, Mickelson J, Murray J, Antczak DF, Womack JE, Skow LC (2003). The first-generation whole-genome radiation hybrid map in the horse identifies conserved segments in human and mouse genomes. GENOME RES. 4, 742-51
  • Raudsepp T, Kata SR, Piumi F, Swinburne J, Womack JE, Skow LC, Chowdhary BP (2002). Conservation of gene order between horse and human X chromosomes as evidenced through radiation hybrid mapping. GENOMICS. 3, 451-7
  • McShane RD, Gallagher DS Jr, Newkirk H, Taylor JF, Burzlaff JD, Davis SK, Skow LC (2001). Physical localization and order of genes in the class I region of the bovine MHC. ANIM GENET. 5, 235-9
  • Skow LC, Nall CA (1996). A second polymorphism in exon 2 of the BoLA-DYA gene. ANIM GENET. 3, 216-7
  • Skow LC, Snaples SN, Davis SK, Taylor JF, Huang B, Gallagher DH (1996). Localization of bovine lymphocyte antigen (BoLA) DYA and class I loci to different regions of chromosome 23. MAMM GENOME. 5, 388-9
  • DeWoody JA, Honeycutt RL, Skow LC (1995). Microsatellite markers in white-tailed deer. J HERED. 4, 317-9
  • Gallagher DS Jr, Grosz MD, Womack JE, Skow LC (1993). Chromosomal localization of HSP70 genes in cattle. MAMM GENOME. 7, 388-90
  • Joyce JR, Martin JE, Storts RW, Skow L (1990). Iridial hypoplasia (aniridia) accompanied by limbic dermoids and cataracts in a group of related quarterhorses. EQUINE VET J SUPPL. 10, 26-8
  • Theilmann JL, Skow LC, Baker JF, Womack JE (1989). Restriction fragment length polymorphisms for growth hormone, prolactin, osteonectin, alpha crystallin, gamma crystallin, fibronectin and 21-steroid hydroxylase in cattle. ANIM GENET. 3, 257-66
  • Skow LC, Donner ME, Huang SM, Gardner JM, Taylor BA, Beamer WG, Lalley PA (1988). Mapping of mouse gamma crystallin genes on chromosome 1. BIOCHEM GENET. 9-10, 557-70
  • Skow LC, Womack JE, Petresh JM, Miller WL (1988). Synteny mapping of the genes for 21 steroid hydroxylase, alpha A crystallin, and class I bovine leukocyte antigen in cattle. DNA. 3, 143-9
  • Adkison LR, Skow LC, Thomas TL, Petrash M, Womack JE (1988). Somatic cell mapping and restriction fragment analysis of bovine genes for fibronectin and gamma crystallin. CYTOGENET CELL GENET. 3, 155-9
  • Doan R, Cohen N, Harrington J, Veazy K, Juras R, Cothran G, McCue ME, Skow L, Dindot SV (2012). Identification of copy number variants in horses. GENOME RES. 5, 899-907
  • Skow LC (1978). Genetic variation at a locus (TAM-1) for submaxillary gland protease in the mouse and its location on chromosome No. 7. GENETICS. 4, 713-24
  • Skow LC, Fox RR, Womack JE (1978). Inherited enzyme variation among JAX strains of domestic rabbits. J HERED. 3, 165-8
  • Fràter-Schröder M, Prochazka M, Haller O, Arwert F, Porck HJ, Skow LC, Lundin LG, Hilkens J, Hilgers J (1985). Localization of the gene for the vitamin B12 binding protein, transcobalamin II, near the centromere on mouse chromosome 11, linked with the hemoglobin alpha-chain locus. BIOCHEM GENET. 1-2, 139-53
  • Popp RA, Popp DM, Johnson FM, Skow LC, Lewis SE (1985). Hematology of a murine beta-thalassemia: a longitudinal study. ANN N Y ACAD SCI. 445, 432-44
  • Skow LC, Kunz HW, Gill TJ 3rd (1985). Linkage of the locus encoding the A chain of alpha-crystallin (Acry-1) to the major histocompatibility complex in the rat. IMMUNOGENETICS. 3, 291-3
  • Antonucci TK, Von Deimling OH, Rosenblum BB, Skow LC, Meisler MH (1984). Conserved linkage within a 4-cM region of mouse chromosome 9 and human chromosome 11. GENETICS. 3, 463-75
  • Skow LC, Burkhart BA, Johnson FM, Popp RA, Popp DM, Goldberg SZ, Anderson WF, Barnett LB, Lewis SE (1983). A mouse model for beta-thalassemia. CELL. 3, 1043-52
  • Popp RA, Bailiff EG, Skow LC, Johnson FM, Lewis SE (1983). Analysis of a mouse alpha-globin gene mutation induced by ethylnitrosourea. GENETICS. 1, 157-67
  • Skow LC (1982). Location of a gene controlling electrophoretic variation in mouse gamma-crystallins. EXP EYE RES. 4, 509-16
  • Uiterdijk HG, Ponder BA, Festing MF, Hilgers J, Skow L, Van Nie R (1986). The gene controlling the binding sites of Dolichos biflorus agglutinin, Dlb-1, is on chromosome 11 of the mouse. GENET RES. 2, 125-9
  • Lewis SE, Barnett LB, Felton C, Johnson FM, Skow LC, Cacheiro N, Shelby MD (1986). Dominant visible and electrophoretically expressed mutations induced in male mice exposed to ethylene oxide by inhalation. ENVIRON MUTAGEN. 6, 867-72
  • Donner ME, Skow LC, Kunz HW, Gill TJ 3rd (1985). Electrophoretic variation in low molecular weight lens crystallins from inbred strains of rats. BIOCHEM GENET. 9-10, 787-800
  • Lewis SE, Johnson FM, Skow LC, Popp D, Barnett LB, Popp RA (1985). A mutation in the beta-globin gene detected in the progeny of a female mouse treated with ethylnitrosourea. PROC NATL ACAD SCI U S A. 17, 5829-31
  • Skow LC, Donner ME (1985). The locus encoding alpha A-crystallin is closely linked to H-2K on mouse chromosome 17. GENETICS. 4, 723-32
  • Wagner ML, Goh G, Wu JT, Morrison LY, Alexander LJ, Raudsepp T, Skow LC, Chowdhary BP, Mickelson JR (2004). Sixty-seven new equine microsatellite loci assigned to the equine radiation hybrid map. ANIM GENET. 6, 484-6
  • Mickelson JR, Wagner ML, Goh G, Wu JT, Morrison LY, Alexander LJ, Raudsepp T, Skow LC, Chowdhary BP, Swinburne JE, Binns MM (2004). Thirty-five new equine microsatellite loci assigned to genetic linkage and radiation hybrid maps. ANIM GENET. 6, 481-4
  • Wagner ML, Goh G, Wu JT, Raudsepp T, Morrison LY, Alexander LJ, Skow LC, Chowdhary BP, Mickelson JR (2004). Radiation hybrid mapping of 63 previously unreported equine microsatellite loci. ANIM GENET. 2, 159-62
  • Ward TL, Valberg SJ, Lear TL, Guérin G, Milenkovic D, Swinburne JE, Binns MM, Raudsepp T, Skow L, Chowdhary BP, Mickelson JR (2003). Genetic mapping of GBE1 and its association with glycogen storage disease IV in American Quarter horses. CYTOGENET GENOME RES. 1-4, 201-6
  • Wagner ML, Goh G, Wu JT, Raudsepp T, Morrison LY, Alexander LJ, Skow LS, Chowdhary BP, Mickelson JR (2004). Radiation hybrid mapping of 75 previously unreported equine microsatellite loci. ANIM GENET. 1, 68-71
  • Guérin G, Bailey E, Bernoco D, Anderson I, Antczak DF, Bell K, Biros I, Bjørnstad G, Bowling AT, Brandon R, Caetano AR, Cholewinski G, Colling D, Eggleston M, Ellis N, Flynn J, Gralak B, Hasegawa T, Ketchum M, Lindgren G, Lyons LA, Millon LV, Mariat D, Murray J, Neau A, Røed K, Sandberg K, Skow LC, Tammen I, Tozaki T, Van Dyk E, Weiss B, Young A, Ziegle J (2003). The second generation of the International Equine Gene Mapping Workshop half-sibling linkage map. ANIM GENET. 3, 161-8
  • Sena L, Schneider MP, Brenig B, Honeycutt RL, Womack JE, Skow LC (2003). Polymorphisms in MHC-DRA and -DRB alleles of water buffalo (Bubalus bubalis) reveal different features from cattle DR alleles. ANIM GENET. 1, 1-10
  • Chowdhary BP, Raudsepp T, Honeycutt D, Owens EK, Piumi F, Guérin G, Matise TC, Kata SR, Womack JE, Skow LC (2002). Construction of a 5000(rad) whole-genome radiation hybrid panel in the horse and generation of a comprehensive and comparative map for ECA11. MAMM GENOME. 2, 89-94
  • Wambugu J, Kanguha E, Hanotte O, Davis S, Taylor J, Skow L, Brunner R, Schwerin M, Teale A, Iraqi F (2001). Identification of two polymorphic microsatellite repeats on a bovine TNFA-containing BAC clone. ANIM GENET. 2, 105-6
  • Ward TJ, Skow LC, Gallagher DS, Schnabel RD, Nall CA, Kolenda CE, Davis SK, Taylor JF, Derr JN (2001). Differential introgression of uniparentally inherited markers in bison populations with hybrid ancestries. ANIM GENET. 2, 89-91
  • Lindgren G, Breen M, Godard S, Bowling A, Murray J, Scavone M, Skow L, Sandberg K, Guérin G, Binns M, Ellegren H (2001). Mapping of 13 horse genes by fluorescence in-situ hybridization (FISH) and somatic cell hybrid analysis. CHROMOSOME RES. 1, 53-9
  • Rao GN, Birnbaum LS, Collins JJ, Tennant RW, Skow LC (1988). Mouse strains for chemical carcinogenicity studies: overview of a workshop. FUNDAM APPL TOXICOL. 3, 385-94
  • Skow LC, Adkison L, Womack JE, Beamer WG, Taylor BA (1987). Mapping of the mouse fibronectin gene (Fn-1) to chromosome 1: conservation of the Idh-1-Cryg-Fn-1 synteny group in mammals. GENOMICS. 3, 283-6
  • Fritz KL, Kaese HJ, Valberg SJ, Hendrickson JA, Rendahl AK, Bellone RR, Dynes KM, Wagner ML, Lucio MA, Cuomo FM, Brinkmeyer-Langford CL, Skow LC, Mickelson JR, Rutherford MS, McCue ME (2014). Genetic risk factors for insidious equine recurrent uveitis in Appaloosa horses. ANIM GENET. 3, 392-9
  • Helchowski CM, Skow LF, Roberts KH, Chute CL, Canman CE (2013). A small ubiquitin binding domain inhibits ubiquitin-dependent protein recruitment to DNA repair foci. CELL CYCLE. 24, 3749-58
  • Stafuzza NB, Greco AJ, Grant JR, Abbey CA, Gill CA, Raudsepp T, Skow LC, Womack JE, Riggs PK, Amaral ME (2013). A high-resolution radiation hybrid map of the river buffalo major histocompatibility complex and comparison with BoLA. ANIM GENET. 4, 369-76
  • Brinkmeyer-Langford CL, Cai JJ, Gill CA, Skow LC (2013). Microsatellite variation in the equine MHC. ANIM GENET. 3, 267-75
  • Sena L, Schneider MP, Brenig BB, Honeycutt RL, Honeycutt DA, Womack JE, Skow LC (2011). Polymorphism and gene organization of water buffalo MHC-DQB genes show homology to the BoLA DQB region. ANIM GENET. 4, 378-85
  • Wagner ML, Raudsepp T, Goh G, Agarwala R, Schaffer AA, Dranchak PK, Brinkmeyer-Langford C, Skow LC, Chowdhary BP, Mickelson JR (2006). A 1.3-Mb interval map of equine homologs of HSA2. CYTOGENET GENOME RES. 3-4, 227-34
  • Bailey E, Skow L, Bernoco D, DelValle A, Scavone MD, Bowling AT, Murray JD (2000). Equine dinucleotide repeat loci LEX071 through LEX078. ANIM GENET. 4, 286-7
  • Shiue Y-L, Millon LV, Skow LC, Honeycutt D, Murray JD, Bowling AT (2000). Synteny and regional marker order assignment of 26 type I and microsatellite markers to the horse X- and Y-chromosomes. CHROMOSOME RES. 1, 45-55
  • Bailey E, Reid RC, Skow LC, Mathiason K, Lear TL, McGuire TC (1997). Linkage of the gene for equine combined immunodeficiency disease to microsatellite markers HTG8 and HTG4; synteny and FISH mapping to ECA9. ANIM GENET. 4, 268-73
  • Iannuzzi L, Skow L, Di Meo GP, Gallagher DS, Womack JE (1997). Comparative FISH-mapping of villin (VIL) gene in river buffalo, sheep and goat chromosomes. CHROMOSOME RES. 3, 199-202
  • Zimring DC, Lamoreux ML, Millichamp NJ, Skow LC (1996). Microphthalmia cloudy-eye (mi(ce)): a new murine allele. J HERED. 4, 334-8
  • Nichols J, Rheingans P, Lothenbach D, McGeachie R, Skow L, McKim J (1994). Three-dimensional visualization of physiologically based kinetic model outputs. ENVIRON HEALTH PERSPECT. 11, 952-6
  • Steingrímsson E, Moore KJ, Lamoreux ML, Ferré-D'Amaré AR, Burley SK, Zimring DC, Skow LC, Hodgkinson CA, Arnheiter H, Copeland NG (1994). Molecular basis of mouse microphthalmia (mi) mutations helps explain their developmental and phenotypic consequences. NAT GENET. 3, 256-63
  • Skow LC, Goy J, Honeycutt D (1994). Dinucleotide repeat polymorphism near a bovine MHC class I sequence. ANIM GENET. 4, 290
  • Grosz MD, Skow LC, Stone RT (1994). An AluI polymorphism at the bovine 70 kD heat-shock protein-1 (HSP70-1) locus. ANIM GENET. 3, 196
  • Iannuzzi L, Gallagher DS, Womack JE, Di Meo GP, Skow LC, Ferrara LC (1993). Chromosomal localization of the major histocompatibility complex in cattle and river buffalo by fluorescent in situ hybridization. HEREDITAS. 2, 187-90
  • DiGiovanni J, Imamoto A, Naito M, Walker SE, Beltrán L, Chenicek KJ, Skow L (1992). Further genetic analyses of skin tumor promoter susceptibility using inbred and recombinant inbred mice. CARCINOGENESIS. 4, 525-31
  • Burkhart BA, Skow LC, Negishi M (1990). Two steroid 15 alpha-hydroxylase genes and a homologous gene family in mice. GENE. 2, 205-11
  • Wong G, Itakura T, Kawajiri K, Skow L, Negishi M (1989). Gene family of male-specific testosterone 16 alpha-hydroxylase (C-P-450(16 alpha)) in mice. Organization, differential regulation, and chromosome localization. J BIOL CHEM. 5, 2920-7
  • Popp RA, Bailiff EG, Skow LC, Whitney JB 3rd (1982). The primary structure of genetic variants of mouse hemoglobin. BIOCHEM GENET. 1-2, 199-208

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