Constantine "Kosta" Simintiras
Assistant Professor Department of Veterinary Integrative BiosciencesResearch and Scholarly Interests
Translational Transcellular and Interstitial Fluidomics Laboratory (TIFL)
Short Bio
Dr. Kosta Simintiras joins VIBS as an assistant professor, bringing with him a research program at the intersection of reproductive biology, biochemistry, and human medicine. He arrives from Louisiana State University, where as a faculty member he led the Integrated Interstitial and Transcellular Fluidome Laboratory. There, he examined the biochemistry of non-vascular extracellular fluids and their role in cell-to-cell communication in health and disease. His higher education, including a Ph.D. from Hull York Medical School, is from the United Kingdom.
Simintiras says he was drawn to Texas A&M by both its reputation and its people, describing the VMBS as the “crown jewel” of U.S. veterinary schools. He plans to leverage the university’s research infrastructure and collaborative environment, including the Interdisciplinary Faculty of Reproductive Biology, to advance his research on the mammalian female reproductive tract using a multi-omics approach. Goals of his research include improving cattle reproductive outcomes and better understanding the regeneration and degeneration of the uterine lining.
Appointments & Education
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Assistant Professor of Reproductive Biology & Pregnancy | Department of Veterinary Integrative Biosciences | Texas A&M University | 08.2026 – Present
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Assistant Professor of Reproductive & Developmental Biology | School of Animal Sciences | Louisiana State University | 03.2022 – 07.2026
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Postdoctoral Research Fellow | P.I. Dr. Thomas Spencer | Division of Animal Science | The University of Missouri | 11.2019 – 02.2022
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Postdoctoral Research Fellow | P.I. Dr. Patrick Lonergan | School of Agriculture and Food Science | University College Dublin, Ireland | 03.2017 – 09.2019
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Ph.D. in Medical Science | Center for Cardiovascular and Metabolic Research | The Hull York Medical School, UK | 01.2012 – 12.2016
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M.Sc. in Biomedical Engineering | Department of Bioengineering | Imperial College London, UK | 10.2010 – 09.2011
- B.Sc. in Biochemistry | Department of Biology | The University of York, UK | 10.2007 – 06.2010
- 70% Research
- 20% Teaching
- 10% Service
Roughly 60% of body weight is fluid. Around two-thirds of this is intracellular (within cells), approximately one quarter is interstitial (between cells), 8% or so is plasma (blood), and about 1% is transcellular.
Transcellular fluids are the specialized substances within defined compartments — such as the choroid plexus (cerebrospinal fluid), eye (vitreous humor), joints (synovial fluid), and the female reproductive tract (vaginal, cervical, uterine, oviductal, and follicular fluids). We study this overlooked 1%, alongside select interstitial fluids that bathe our cells.
Our primary focus is the uterine cavity, where maternal-embryo communication is orchestrated, in addition to the endometrial interstitium, where systemic endocrine and local epithelial-stromal juxtacrine and paracrine communication coordinates monthly endometrial regeneration.
Rather than studying cells in isolation, we center on the extracellular environments connecting them — interrogating these fluids to gain mechanistic insight into the communication networks that drive physiological processes and go awry in disease.
Most mechanics will tell you: check the fluids first. We took that advice seriously.
Please reach out to simintiras@tamu.edu if interested in joining the team.