Texas A&M University 150 Here for Good logo
Celebrating 110 Years of Service & Science at the College of Veterinary Medicine & Biomedical Sciences
Celebrate With Us
Joe Arosh

Joe Arosh

Professor Department of Veterinary Integrative Biosciences
Contact
JArosh@cvm.tamu.edu
9798456173
TAMU Mailstop: 4458

Research and Scholarly Interests

Central role of prostaglandins on molecular and cellular aspects of reproductive processes, gynecologic diseases and endocrine cancers.

EDUCATION

Ph.D., Laval University, Canada

M.V.Sc., Madras Veterinary College, India

B.V.Sc., Madras Veterinary College, India

  • Sivakumar KK, Stanley JA, Arosh JA, Pepling ME, Burghardt RC, Banu SK (2014). Prenatal exposure to chromium induces early reproductive senescence by increasing germ cell apoptosis and advancing germ cell cyst breakdown in the F1 offspring. DEV BIOL. 1, 22-34
  • Lebovic DI, Kavoussi SK, Lee J, Banu SK, Arosh JA (2013). PPARγ activation inhibits growth and survival of human endometriotic cells by suppressing estrogen biosynthesis and PGE2 signaling. ENDOCRINOLOGY. 12, 4803-13
  • Lee J, McCracken JA, Banu SK, Arosh JA (2013). Intrauterine inhibition of prostaglandin transporter protein blocks release of luteolytic PGF2alpha pulses without suppressing endometrial expression of estradiol or oxytocin receptor in ruminants. BIOL REPROD. 2, 27
  • Stanley JA, Sivakumar KK, Nithy TK, Arosh JA, Hoyer PB, Burghardt RC, Banu SK (2013). Postnatal exposure to chromium through mother's milk accelerates follicular atresia in F1 offspring through increased oxidative stress and depletion of antioxidant enzymes. FREE RADIC BIOL MED., 179-196
  • Lee J, Banu SK, Burghardt RC, Starzinski-Powitz A, Arosh JA (2013). Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits adhesion of human endometriotic epithelial and stromal cells through suppression of integrin-mediated mechanisms. BIOL REPROD. 3, 77
  • Lee J, Banu SK, Nithy TK, Stanley JA, Arosh JA (2012). Early pregnancy induced expression of prostaglandin E2 receptors EP2 and EP4 in the ovine endometrium and regulated by interferon tau through multiple cell signaling pathways. MOL CELL ENDOCRINOL. 1, 211-23
  • Stanley JA, Lee J, Nithy TK, Arosh JA, Burghardt RC, Banu SK (2011). Chromium-VI arrests cell cycle and decreases granulosa cell proliferation by down-regulating cyclin-dependent kinases (CDK) and cyclins and up-regulating CDK-inhibitors. REPROD TOXICOL. 1, 112-23
  • Banu SK, Stanley JA, Lee J, Stephen SD, Arosh JA, Hoyer PB, Burghardt RC (2011). Hexavalent chromium-induced apoptosis of granulosa cells involves selective sub-cellular translocation of Bcl-2 members, ERK1/2 and p53. TOXICOL APPL PHARMACOL. 3, 253-66
  • Lee J, Banu SK, Subbarao T, Starzinski-Powitz A, Arosh JA (2011). Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits invasion of human immortalized endometriotic epithelial and stromal cells through suppression of metalloproteinases. MOL CELL ENDOCRINOL. 1-2, 306-13
  • Banu SK, Lee J, Stephen SD, Nithy TK, Arosh JA (2010). Interferon tau regulates PGF2alpha release from the ovine endometrial epithelial cells via activation of novel JAK/EGFR/ERK/EGR-1 pathways. MOL ENDOCRINOL. 12, 2315-30
  • Lee J, McCracken JA, Banu SK, Rodriguez R, Nithy TK, Arosh JA (2010). Transport of prostaglandin F(2alpha) pulses from the uterus to the ovary at the time of luteolysis in ruminants is regulated by prostaglandin transporter-mediated mechanisms. ENDOCRINOLOGY. 7, 3326-35
  • Lee J, Banu SK, Rodriguez R, Starzinski-Powitz A, Arosh JA (2010). Selective blockade of prostaglandin E2 receptors EP2 and EP4 signaling inhibits proliferation of human endometriotic epithelial cells and stromal cells through distinct cell cycle arrest. FERTIL STERIL. 8, 2498-506
  • Banu SK, Lee J, Speights VO Jr, Starzinski-Powitz A, Arosh JA (2009). Selective inhibition of prostaglandin E2 receptors EP2 and EP4 induces apoptosis of human endometriotic cells through suppression of ERK1/2, AKT, NFkappaB, and beta-catenin pathways and activation of intrinsic apoptotic mechanisms. MOL ENDOCRINOL. 8, 1291-305
  • Banu SK, Starzinski-Powitz A, Speights VO, Burghardt RC, Arosh JA (2009). Induction of peritoneal endometriosis in nude mice with use of human immortalized endometriosis epithelial and stromal cells: a potential experimental tool to study molecular pathogenesis of endometriosis in humans. FERTIL STERIL. 5 Suppl, 2199-209
  • Banu SK, Lee J, Speights VO Jr, Starzinski-Powitz A, Arosh JA (2008). Cyclooxygenase-2 regulates survival, migration, and invasion of human endometriotic cells through multiple mechanisms. ENDOCRINOLOGY. 3, 1180-9
  • Banu SK, Lee J, Starzinski-Powitz A, Arosh JA (2008). Gene expression profiles and functional characterization of human immortalized endometriotic epithelial and stromal cells. FERTIL STERIL. 4, 972-87
  • Banu SK, Lee J, Satterfield MC, Spencer TE, Bazer FW, Arosh JA (2008). Molecular cloning and characterization of prostaglandin (PG) transporter in ovine endometrium: role for multiple cell signaling pathways in transport of PGF2alpha. ENDOCRINOLOGY. 1, 219-31
  • Joe A Arosh, Sakhila K Banu, John A McCracken (2016). Novel concepts on the role of prostaglandins on luteal maintenance and maternal recognition and establishment of pregnancy in ruminants. JOURNAL OF DAIRY SCIENCE. 7, 5926-40
  • Sakhila K Banu, Jone A Stanley, Kirthiram K Sivakumar, Joe A Arosh, Robert C Burghardt (2016). Resveratrol protects the ovary against chromium-toxicity by enhancing endogenous antioxidant enzymes and inhibiting metabolic clearance of estradiol. TOXICOLOGY AND APPLIED PHARMACOLOGY., 65-78
  • JeHoon Lee, Sakhila K Banu, John A McCracken, Joe A Arosh (2016). Early pregnancy modulates survival and apoptosis pathways in the corpus luteum in sheep. REPRODUCTION (CAMBRIDGE, ENGLAND). 3, 187-202
  • Jone A Stanley, Joe A Arosh, Robert C Burghardt, Sakhila K Banu (2015). A fetal whole ovarian culture model for the evaluation of CrVI-induced developmental toxicity during germ cell nest breakdown. TOXICOLOGY AND APPLIED PHARMACOLOGY. 1, 58-69
  • Joe A Arosh, JeHoon Lee, Dakshnapriya Balasubbramanian, Jone A Stanley, Charles R Long, Mary W Meagher, Kevin G Osteen, Kaylon L Bruner-Tran, Robert C Burghardt, Anna Starzinski-Powitz, Sakhila K Banu (2015). Molecular and preclinical basis to inhibit PGE2 receptors EP2 and EP4 as a novel nonsteroidal therapy for endometriosis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 31, 9716-21
  • Joe A Arosh, JeHoon Lee, Anna Starzinski-Powitz, Sakhila K Banu (2015). Selective inhibition of prostaglandin E2 receptors EP2 and EP4 modulates DNA methylation and histone modification machinery proteins in human endometriotic cells. MOLECULAR AND CELLULAR ENDOCRINOLOGY., 51-8
  • Sakhila K Banu, Jone A Stanley, Kirthiram K Sivakumar, Joe A Arosh, Rola Barhoumi, Robert C Burghardt (2015). Identifying a novel role for X-prolyl aminopeptidase (Xpnpep) 2 in CrVI-induced adverse effects on germ cell nest breakdown and follicle development in rats. BIOLOGY OF REPRODUCTION. 3, 67
  • JeHoon Lee, John A McCracken, Jone A Stanley, Thamizh K Nithy, Sakhila K Banu, Joe A Arosh (2012). Intraluteal prostaglandin biosynthesis and signaling are selectively directed towards PGF2alpha during luteolysis but towards PGE2 during the establishment of pregnancy in sheep. BIOLOGY OF REPRODUCTION. 4, 97
  • J A McCracken, E E Custer, D T Schreiber, P C W Tsang, C S Keator, J A Arosh (2012). A new in vivo model for luteolysis using systemic pulsatile infusions of PGF(2α). PROSTAGLANDINS & OTHER LIPID MEDIATORS. 3-4, 90-6
  • JeHoon Lee, Sakhila K Banu, Thamizh K Nithy, Jone A Stanley, Joe A Arosh (2011). Early pregnancy induced expression of prostaglandin E2 receptors EP2 and EP4 in the ovine endometrium and regulated by interferon tau through multiple cell signaling pathways. MOLECULAR AND CELLULAR ENDOCRINOLOGY. 1, 211-23
  • Melinda E McConaha, Tianbing Ding, John A Lucas, Joe A Arosh, Kevin G Osteen, Kaylon L Bruner-Tran (2011). Preconception omega-3 fatty acid supplementation of adult male mice with a history of developmental 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure prevents preterm birth in unexposed female partners. REPRODUCTION (CAMBRIDGE, ENGLAND). 2, 235-41
  • Jone A Stanley, JeHoon Lee, Thamizh K Nithy, Joe A Arosh, Robert C Burghardt, Sakhila K Banu (2011). Chromium-VI arrests cell cycle and decreases granulosa cell proliferation by down-regulating cyclin-dependent kinases (CDK) and cyclins and up-regulating CDK-inhibitors. REPRODUCTIVE TOXICOLOGY (ELMSFORD, N.Y.). 1, 112-23
  • Sakhila K Banu, Jone A Stanley, Jehoon Lee, Sam D Stephen, Joe A Arosh, Patricia B Hoyer, Robert C Burghardt (2011). Hexavalent chromium-induced apoptosis of granulosa cells involves selective sub-cellular translocation of Bcl-2 members, ERK1/2 and p53. TOXICOLOGY AND APPLIED PHARMACOLOGY. 3, 253-66
  • JeHoon Lee, Sakhila K Banu, Thenmozhi Subbarao, Anna Starzinski-Powitz, Joe A Arosh (2010). Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits invasion of human immortalized endometriotic epithelial and stromal cells through suppression of metalloproteinases. MOLECULAR AND CELLULAR ENDOCRINOLOGY. 1-2, 306-13
  • Sakhila K Banu, JeHoon Lee, Sam D Stephen, Thamizh K Nithy, Joe A Arosh (2010). Interferon tau regulates PGF2alpha release from the ovine endometrial epithelial cells via activation of novel JAK/EGFR/ERK/EGR-1 pathways. MOLECULAR ENDOCRINOLOGY (BALTIMORE, MD.). 12, 2315-30
  • JeHoon Lee, John A McCracken, Sakhila K Banu, Royce Rodriguez, Thamizh K Nithy, Joe A Arosh (2010). Transport of prostaglandin F(2alpha) pulses from the uterus to the ovary at the time of luteolysis in ruminants is regulated by prostaglandin transporter-mediated mechanisms. ENDOCRINOLOGY. 7, 3326-35
  • JeHoon Lee, Sakhila K Banu, Royce Rodriguez, Anna Starzinski-Powitz, Joe A Arosh (2010). Selective blockade of prostaglandin E2 receptors EP2 and EP4 signaling inhibits proliferation of human endometriotic epithelial cells and stromal cells through distinct cell cycle arrest. FERTILITY AND STERILITY. 8, 2498-506
  • Sakhila K Banu, JeHoon Lee, V O Speights, Anna Starzinski-Powitz, Joe A Arosh (2009). Selective inhibition of prostaglandin E2 receptors EP2 and EP4 induces apoptosis of human endometriotic cells through suppression of ERK1/2, AKT, NFkappaB, and beta-catenin pathways and activation of intrinsic apoptotic mechanisms. MOLECULAR ENDOCRINOLOGY (BALTIMORE, MD.). 8, 1291-305
  • Sakhila K Banu, Anna Starzinski-Powitz, V O Speights, Robert C Burghardt, Joe A Arosh (2009). Induction of peritoneal endometriosis in nude mice with use of human immortalized endometriosis epithelial and stromal cells: a potential experimental tool to study molecular pathogenesis of endometriosis in humans. FERTILITY AND STERILITY. 5 Suppl, 2199-209
  • Sakhila K Banu, Jawahar B Samuel, Joe A Arosh, Robert C Burghardt, Michael M Aruldhas (2008). Lactational exposure to hexavalent chromium delays puberty by impairing ovarian development, steroidogenesis and pituitary hormone synthesis in developing Wistar rats. TOXICOLOGY AND APPLIED PHARMACOLOGY. 2, 180-9
  • S K Banu, J Lee, V O Speights, A Starzinski-Powitz, J A Arosh (2008). Cyclooxygenase-2 regulates survival, migration, and invasion of human endometriotic cells through multiple mechanisms. ENDOCRINOLOGY. 3, 1180-9
  • Sakhila K Banu, JeHoon Lee, Anna Starzinski-Powitz, Joe A Arosh (2008). Gene expression profiles and functional characterization of human immortalized endometriotic epithelial and stromal cells. FERTILITY AND STERILITY. 4, 972-87
  • S K Banu, J Lee, M C Satterfield, T E Spencer, F W Bazer, J A Arosh (2007). Molecular cloning and characterization of prostaglandin (PG) transporter in ovine endometrium: role for multiple cell signaling pathways in transport of PGF2alpha. ENDOCRINOLOGY. 1, 219-31
  • S K Banu, J A Arosh, P Chapdelaine, M A Fortier (2005). Expression of prostaglandin transporter in the bovine uterus and fetal membranes during pregnancy. BIOLOGY OF REPRODUCTION. 2, 230-6
  • J A Arosh, S K Banu, S Kimmins, P Chapdelaine, L A Maclaren, M A Fortier (2004). Effect of interferon-tau on prostaglandin biosynthesis, transport, and signaling at the time of maternal recognition of pregnancy in cattle: evidence of polycrine actions of prostaglandin E2. ENDOCRINOLOGY. 11, 5280-93
  • Kaylon L Bruner-Tran, Tianbing Ding, Kallie B Yeoman, Anthony Archibong, Joe A Arosh, Kevin G Osteen (2014). Developmental exposure of mice to dioxin promotes transgenerational testicular inflammation and an increased risk of preterm birth in unexposed mating partners. PLOS ONE. 8,
  • JeHoon Lee, Jone A Stanley, John A McCracken, Sakhila K Banu, Joe A Arosh (2014). Intrauterine coadministration of ERK1/2 inhibitor U0126 inhibits interferon TAU action in the endometrium and restores luteolytic PGF2alpha pulses in sheep. BIOLOGY OF REPRODUCTION. 2, 46
  • Jone A Stanley, Kirthiram K Sivakumar, Joe A Arosh, Robert C Burghardt, Sakhila K Banu (2014). Edaravone mitigates hexavalent chromium-induced oxidative stress and depletion of antioxidant enzymes while estrogen restores antioxidant enzymes in the rat ovary in F1 offspring. BIOLOGY OF REPRODUCTION. 1, 12
  • Kirthiram K Sivakumar, Jone A Stanley, Joe A Arosh, Melissa E Pepling, Robert C Burghardt, Sakhila K Banu (2014). Prenatal exposure to chromium induces early reproductive senescence by increasing germ cell apoptosis and advancing germ cell cyst breakdown in the F1 offspring. DEVELOPMENTAL BIOLOGY. 1, 22-34
  • Dan I Lebovic, Shahryar K Kavoussi, JeHoon Lee, Sakhila K Banu, Joe A Arosh (2013). PPARγ activation inhibits growth and survival of human endometriotic cells by suppressing estrogen biosynthesis and PGE2 signaling. ENDOCRINOLOGY. 12, 4803-13
  • JeHoon Lee, John A McCracken, Sakhila K Banu, Joe A Arosh (2013). Intrauterine inhibition of prostaglandin transporter protein blocks release of luteolytic PGF2alpha pulses without suppressing endometrial expression of estradiol or oxytocin receptor in ruminants. BIOLOGY OF REPRODUCTION. 2, 27
  • Jone A Stanley, Kirthiram K Sivakumar, Thamizh K Nithy, Joe A Arosh, Patricia B Hoyer, Robert C Burghardt, Sakhila K Banu (2014). Postnatal exposure to chromium through mother's milk accelerates follicular atresia in F1 offspring through increased oxidative stress and depletion of antioxidant enzymes. FREE RADICAL BIOLOGY & MEDICINE., 179-96
  • JeHoon Lee, Sakhila K Banu, Robert C Burghardt, Anna Starzinski-Powitz, Joe A Arosh (2013). Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits adhesion of human endometriotic epithelial and stromal cells through suppression of integrin-mediated mechanisms. BIOLOGY OF REPRODUCTION. 3, 77
  • J A Arosh, S K Banu, P Chapdelaine, E Madore, J Sirois, M A Fortier (2004). Prostaglandin biosynthesis, transport, and signaling in corpus luteum: a basis for autoregulation of luteal function. ENDOCRINOLOGY. 5, 2551-60
  • J A Arosh, S K Banu, P Chapdelaine, M A Fortier (2003). Temporal and tissue-specific expression of prostaglandin receptors EP2, EP3, EP4, FP, and cyclooxygenases 1 and 2 in uterus and fetal membranes during bovine pregnancy. ENDOCRINOLOGY. 1, 407-17
  • Vincent Emond, Leslie A MacLaren, Sarah Kimmins, Joe A Arosh, Michel A Fortier, Raymond D Lambert (2003). Expression of cyclooxygenase-2 and granulocyte-macrophage colony-stimulating factor in the endometrial epithelium of the cow is up-regulated during early pregnancy and in response to intrauterine infusions of interferon-tau. BIOLOGY OF REPRODUCTION. 1, 54-64
  • Sakhila K Banu, Joe A Arosh, Pierre Chapdelaine, Michel A Fortier (2003). Molecular cloning and spatio-temporal expression of the prostaglandin transporter: a basis for the action of prostaglandins in the bovine reproductive system. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 20, 11747-52
  • J A Arosh, S K Banu, P Chapdelaine, V Emond, J J Kim, L A MacLaren, M A Fortier (2003). Molecular cloning and characterization of bovine prostaglandin E2 receptors EP2 and EP4: expression and regulation in endometrium and myometrium during the estrous cycle and early pregnancy. ENDOCRINOLOGY. 7, 3076-91
  • Eric Madore, Nathalie Harvey, Julie Parent, Pierre Chapdelaine, Joe A Arosh, Michel A Fortier (2003). An aldose reductase with 20 alpha-hydroxysteroid dehydrogenase activity is most likely the enzyme responsible for the production of prostaglandin f2 alpha in the bovine endometrium. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 13, 11205-12
  • Joe A Arosh, Julie Parent, Pierre Chapdelaine, Jean Sirois, Michel A Fortier (2002). Expression of cyclooxygenases 1 and 2 and prostaglandin E synthase in bovine endometrial tissue during the estrous cycle. BIOLOGY OF REPRODUCTION. 1, 161-9
  • S K Banu, J A Arosh, P Govindarajulu, M M Aruldhas (2002). Testosterone and estradiol differentially regulate thyroid growth in Wistar rats from immature to adult age. ENDOCRINE RESEARCH. 4, 447-63

ACADEMICS

DEPARTMENTS

OUTREACH

UNITS