W. Brian Saunders
Professor, Asst. Dept. Head for Clinical Trials (VSCS), & Linda & Dennis H. Clark ’68 Endowed Chair in Clinical ResearchResearch and Scholarly Interests
Orthopedic Surgery:
- Cell Biology
- Total Joint Replacement
- Arthroscopy
- Minimally Invasive Osteosynthesis (MIO)
- Cranial Cruciate Ligament Disease
Research interests:
- Cell-Matrix Interactions
- Matrix Metalloproteinases (MMPs)
- Canine and Human Adult Mesenchymal Stem Sells (MSCs)
- Tissue Engineering for Bone and Cartilage Defects
Biography
"I am a clinician scientist with advanced training in both cell biology and veterinary orthopedic surgery. After obtaining a DVM and completing a rotating internship at the University of Tennessee, I obtained training in cell biology techniques, as well as more advanced techniques such as gene silencing, cloning, mutagenesis, and viral-mediated gene transfer. Most importantly, I gained expertise with Dr. George Davis’ three-dimensional invasion, morphogenesis, and vascular regression systems. My PhD dissertation described a novel MMP-1 and MMP-10 dependent vascular regression pathway, and subsequent research focused on the role of MT1-MMP and Tissue Inhibitors of MMPs (TIMPs) in endothelial cell lumen formation and stabilization, a process that requires endothelial-pericyte interactions. I published two first author papers with Dr. Davis, and was a co-author on several other publications, most notably a 2006 Nature paper (second author status). After completing my training with Dr. Davis, I concluded my clinical training with a small animal surgical residency. I gained expertise in arthroscopic joint surgery, internal and external fixation of fractures, surgical correction of limb deformities, total hip replacement, and osteochondral grafting. Collectively, I have 20 years of experience with endothelial cell and mesenchymal stem cell (MSC) culture and veterinary orthopedic surgery.
During the initial stages of my career as faculty, I established a fully equipped and independent cell biology lab. We have developed techniques to isolate and characterize adult MSCs from a variety of species. The lab’s mission is to advance the field of canine orthopedics and stem cell therapy for the mutual benefit of veterinary and human orthopedic patients. To date the lab’s efforts have been focused on characterizing canine MSCs for bone and cartilage tissue engineering translational models, development of bone and cartilage tissue engineering devices, and performing clinical trials to determine efficacy of both surgical and medical treatments for debilitating orthopedic conditions.
I am currently the Service Chief for Small Animal Orthopedic Surgery (a team composed of a 18-20 faculty, house officers, and technicians). Clinical activities include diagnosis and treatment of canine and feline bone and joint disorders, including arthroscopic joint surgery, minimally invasive fracture repair, joint replacement, and correction of angular limb deformities. In this setting, I also prescribe non-surgical treatments for osteoarthritis, from NSAIDs and PS-GAGs/HA products to joint supplements and special joint diets. In 2021, I became the Assistant Department Head for Clinical Trials and Biobanking in the Department of Small Animal Clinical Sciences (VSCS). In this capacity, I advise the Office of Veterinary Clinical Investigation and our expanding biorepository of canine tumor, blood, stem cells and tissue specimens."
Education
Diplomate of the American College of Veterinary Surgeons | Germantown, MD
Small Animal Surgery, 2010
Texas A&M University, College of Veterinary Medicine & Biomedical Sciences | College Station, TX
Small Animal Surgery Residency, 2009
Texas A&M University, College of Medicine | College Station, TX
Doctor of Philosophy in Vascular Biology, 2005
University of Tennessee, College of Veterinary Medicine | Knoxville, TN
Small Animal Medicine & Surgery Internship, 2002
Texas A&M University, College of Veterinary Medicine & Biomedical Sciences | College Station, TX
Doctor of Veterinary Medicine, 2001
Texas A&M University | College Station, TX
Bachelor of Science in Veterinary Science, 1998
Licensure
- Diplomate, American College of Veterinary Surgeons, start 2010, Board Certified
- Texas Veterinary Medical License: 9108
Honors & Awards
| Award/Honor | Organization | Year |
|---|---|---|
Professional Organizations
***denotes publications by mentored residents, interns, or graduate students
Peer-Reviewed Journals
***Silveira CJ, Dobson LK, Gasson SB, Saunders WB. Chondrogenesis of canine marrow stromal cells (cMSCs) in a serum-free type I collagen system is enhanced by pre-exposure to basic fibroblast growth factor (bFGF). Manuscript in preparation, Stem Cell Res & Ther, Fall 2024.
***Berns CN, Dobson LK, Gasson SB, Davis BW, Saunders WB. Transcriptome patterns in canine and human multipotent stromal cells undergoing osteogenic differentiation. Manuscript in preparation, Stem Cell Reports, Fall 2024.
Dobson LK, Beltran FO, Gasson SB, Pfau-Cloud MR, Lawson ZT, Pool RR, Moreno MR, Grunlan MA, Saunders WB. Self-fitting shape memory polymer scaffolds (SMPs) for treatment of craniomaxillofacial defects. Manuscript in preparation, Tissue Engineering Part A, Fall 2024.
***Gasson SB, Dobson LK, Pfau-Cloud MR, Beltran FO, Gregory CA, Grunlan MA, Saunders WB. Shape memory polymer scaffolds – Utility for in vitro osteogenesis of canine multipotent stromal cells. JBMR-B, 112 (12): e35503, Dec 2024. PMID: 39587932.
***Gasson SB, Dobson LK, Pfau-Cloud MR, Beltran FO, Pool RR, Gregory CA, Grunlan MA, Saunders WB. Biocompatibility and bone regeneration by shape memory polymer scaffolds. JBMR-A, online ahead of print, Oct 2024. PMID: 39404147.
***Lawson ZT, Hollenbeck DL, Siveira CJ, Moreno MR, Robbins AB, Saunders WB. Quasi-static mechanical evaluation of canine cementless total hip replacement broaches: effect of tooth design on broach and stem insertion. BMC Vet Res, 20 (1), 2024. PMID: 38783269
Zderic I, Varga P, Styger U, Drenchev L, Gueorguiev B, Asimus E, Saunders W, Kowaleski M, Boudrieau RJ, Dejardin LM. Mechanical assessment of two hybrid plate designs for canine pancarpal arthrodesis under cyclic loading. Frontiers Bioeng Biotech, 11:11709777, eCollection, 2023. PMID: 37064234.
Abibe RB, Rahal SC, Saunders WB. Ligamentum teres reconstruction using autogenous semitendinosus tendon with toggle technique in rabbits. Peer J. eCollection, 2023. 11:e14777 DOI 10.7717/peerj.14777. PMID: 36987457.
Saunders WB, Dejardin LM, Soltys-Niemann EV, Kaulfus CN, Eichelberger BM, Dobson LK, Weeks BR, Kerwin SC, Gregory CA. Angle-stable interlocking nailing in a canine critical-sized femoral defect model for bone regeneration studies: In pursuit of the principle of the 3R’s. Frontiers Bioeng Biotech, 10: 921486, 2022. PMID: 36118571.
***MacIver MA, Dobson LK, Gregory CA, Muneoka K, Saunders WB. Chondrogenesis of canine marrow stromal cells in three-dimensional collagen matrices. PLOS One, 17 (6): e0269571, 2022. PMID:35679245
***Silveira CJ, Barnes KH, Kerwin SC, Saunders WB. Greater trochanter morphology and association with patient demographics, surgical factors, and post-operative stem position: a retrospective assessment of 150 cementless THRs in 135 dogs. BMC Vet Res, 18 (1), 78, 2022. PMID: 35197062
***Dobson LK, Zeitouni S, McNeill EP, Gregory CA, Saunders WB. Canine mesenchymal stromal cell mediated bone regeneration is enhanced in the presence of sub-therapeutic concentrations of BMP-2 in a murine calvarial defect model. Frontiers Bioeng Biotech, eCollection, 9, Fall 2021. PMID: 34796168
***Silveira CJ, Saunders WB. Greater trochanter osteotomy as a component of cementless total hip replacement: five cases in four dogs. Vet Surg, 51 (2), 303-310, 2022. PMID: 34724235
Pfau MR, Beltran FO, Woodard LN, Dobson LK, Gasson SB, Robbins AB, Lawson ZT, Saunders WB, Moreno MR, Grunlan MA. Evaluation of a self-fitting, shape memory polymer scaffold in a rabbit calvarial defect model. Acta Biomaterialia, 136, 233-242, 2021. PMID: 34571270 ***Led the essential induced-injury rabbit calvarial defect studies.
Lawson ZT, Han J, Saunders WB, Grunlan MA, Moreno MR, Robbins AB. Methodology for performing biomechanical push-out tests for evaluating the osseointegration of calvarial defect repair in small animal models. Methods X, eCollection, 8, 2021. PMID: 34754809
Zderic I, Varga P, Styger U, Drenchev L, Gueorguiev B, Asimus E, Saunders WB, Kowaleski MP, Boudrieau RJ, Déjardin LM. Mechanical evaluation of two hybrid locking plate designs for canine pancarpal arthrodesis. BioMed Res Int, eCollection, 2021. PMID: 34513988 ***As a new appointee to the expert group that led this study, I submitted a proposal to obtain a second round of funding to complete this project.
Heffernan JM, Overstreet DJ, Vernon BL, McLemore RY, Nagy T, Moore RC, Badha VS, Childers EP, Nguyen MB, Gentry DD, Calara FM, Saunders WB, Feltis T, McLaren AC. In vivo evaluation of temperature-responsive antimicrobial-loaded PNIPAAm hydrogels for prevention of surgical site infections. J Biomed Mater Res B Appl Biomater, 110 (1), 103-114, 2021. PMID: 34128323 ***Led the induced-injury canine total hip replacement animal model that was a key component of this project.
***Gasson SB, Dobson LK, Chow L, Gregory CA, Dow S, Saunders WB. Optimizing in vitro osteogenesis in canine autologous and induced pluripotent stem cell-derived mesenchymal stromal cells with dexamethasone and BMP-2. Stem Cells & Dev, 30 (4), 214-226, 2021. PMID: 33356875
Gifford AB, Lotsikas PJ, Liska WD, Israel SK, Rochat MC, Saunders WB, Guiot LP, Marcellin-Little DJ, Benjamino KP, Dyce J. Total hip replacement in dogs with contralateral pelvic limb amputation: A retrospective evaluation of 13 cases. Vet Surg, 49 (8), 1487-1496, 2020. PMID: 32916005
McNeil EP, Zeitouni S, Pan S, Haskell A, Cesarek M, Tahan D, Clough BH, Krause U, Dobson LK, Garcia M, Kung C, Zhao Q, Saunders WB, Liu F, Kaunas R, Gregory CA. A pluripotent stem cell-derived matrix with potent osteoregenerative capabilities. Nature Communications, 11 (1): 3025, 2020. PMID: 32541821
***Amadio A, Corriveau KM, Norby B, Stephenson TR, Saunders WB. Effect of proximal abducting ulnar osteotomy (PAUL) on thoracic limb alignment: an ex-vivo study. Vet Surg, 49 (7), 1437-1448, 2020. PMID: 32463515
Diaz-Rodriguez P, Erndt-Marino JD, Gharat T, Munoz Pinto DJ, Samavedi S, Bearden R, Grunlan MA, Saunders WB, Hahn MS. Toward zonally tailored scaffolds for osteochondral differentiation of synovial mesenchymal stem cells. J Biomed Mater Res B Appl Biomater. 107 (6): 2019-2029, 2018. PMID: 30549205
Gharat TP, Diaz-Rodriguez P, Erndt-Marino JD, Vergara ACJ, Pinto DJ, Bearden RN, Huggins SS, Grunlan M, Saunders WB, Hahn MS. A canine in vitro model for evaluation of marrow-derived mesenchymal stromal cell-based bone scaffolds. J Biomed Mater Res A, 106 (9): 2382-2393, 2018. PMID: 29633508
Vasquez B, Hulse D, Beale B, Kerwin S, Andrews C, Saunders WB. Second-look arthroscopic findings after CORA-based leveling osteotomy. Vet Surg, 47 (2): 261-266, 2018. PMID: 28885697
***Bearden RN, Huggins SS, Cummings KJ, Smith R, Gregory CA, Saunders WB. In-vitro characterization of canine multipotent stromal cells isolated from synovium, bone marrow, and adipose tissue: a donor-matched comparative study. Stem Cell Research & Therapy, 8 (1): 1-22, 2017. PMID: 28974260
***Kaufman K, Beale BS, Thames HD, Saunders WB. Articular cartilage scores in cranial cruciate ligament-deficient dogs with or without bucket handle tears of the medial meniscus. Vet Surg, 46 (1): 120-129, 2017. PMID: 27893158
***Ruoff CM, Eichelberger BM, Pool RR, Griffin JF, Cummings KJ, Pozzi A, Padua A, Saunders WB. The use of small field of view 3T MRI for identification of articular cartilage defects in the canine stifle: an ex vivo cadaveric study. Vet Rad Ultra, 57 (6): 601-610, 2016. PMID: 27629105
***Breiteneicher AB, Norby B, Schulz KS, Kerwin SC, Hulse DA, Fox DB, Saunders WB. The effect of sliding humeral osteotomy (SHO) on frontal plane thoracic limb alignment: an ex-vivo canine cadaveric study. Vet Surg, 45 (8): 1095-1107, 2016. PMID: 27735063
Leonard KC, Kowaleski MP, Saunders WB, Boudrieau RJ. Combined tibial plateau leveling osteotomy and tibial tuberosity transposition for treatment of cranial cruciate ligament rupture and medial patellar luxation. Vet Comp Orthop Trauma, 29 (6): 536-40, 2016. PMID: 27739556
***Hans EC, Saunders WB, Beale BS, Hulse DA. Fragmentation of the medial coronoid process in toy and small breed dogs: 13 elbows (2000-2012). J Am Animal Hosp Assoc, 52 (4): 234-241, 2016. PMID: 27259019
***Hans EC, Kerwin SC, Elliott AC, Butler R, Saunders WB, Hulse DA. Outcome following surgical correction of grade 4/4 medial patellar luxation in dogs: 47 stifles (2001-2012). J Am Animal Hosp Assoc, 52 (3): 162-169, 2016. PMID: 27008322
***Huggins SS, Suchodolski JS, Bearden RN, Steiner JM, Saunders WB. Serum concentrations of canine interleukin-1 receptor antagonist protein in healthy dogs after incubation using an autologous serum processing system. Res Vet Sci, 101: 28-33, 2015. PMID: 26267085
***Bonin GA, Baker ST, Davis CA, Hildebrandt AA, Hulse DA, Kerwin SC, Moreno MR, Saunders WB. In vitro biomechanical comparison of a 3.5 mm LC-DCP/intramedullary rod and a 5 mm clamp rod internal fixator (CRIF)/intramedullary rod fixation in a canine femoral gap model. Vet Surg, 43 (7): 860-868, 2013. PMID: 24484218
***Goodrich ZG, Norby B, Eichelberger BM, Friedeck WO, Callis HN, Hulse DA, Kerwin SC, Fox DB, Saunders WB. Thoracic limb alignment in healthy Labrador Retrievers: evaluation of standing versus recumbent frontal plane radiography. Vet Surg, 43 (7): 791-803, 2013. PMID: 24467231
Raske M, Hulse D, Beale B, Saunders WB, Kishi E, Kunze C. Stabilization of the CORA based leveling osteotomy for treatment of cranial cruciate ligament injury using a bone plate augmented with a headless compression screw. Vet Surg, 42 (6): 759-764, 2013. PMID: 23876155
Kishi I, Hulse D, Raske M, Saunders WB, Beale B. Extra-articular stabilization of the canine cranial cruciate ligament injury using Arthrex Corkscrew and FASTak anchors. Open Journal of Veterinary Medicine, 03 (02): 156-160, 2013. DOI: 10.4236/ojvm.2013.32024
Selmic LE, Nelson DA, Saunders AB, Hobson HP, Saunders WB. Intrapericardial technique for PDA ligation: surgical description and outcome in 35 dogs. J Am Animal Hosp Assoc, 49 (10): 31-40, 2013. PMID: 23148137
Hulse DA, Saunders WB, Beale BS, Kowaleski MP. Extra-articular stabilization of the cranial cruciate deficient stifle with anchors systems, Tierarztliche Praxis Kleintiere, 39 (5): 363-367, 2011. PMID: 22134663
Witsberger TH, Hulse DA, Kerwin SC, Saunders WB. Minimally invasive application of a radial plate following placement of an ulnar rod in treating antebrachial fractures: technique and case series. Vet Comp Orthop Trauma, 459-467, 23 (6): 2010. PMID: 20830446
Singletary G, Saunders AB, Saunders WB, Steiner JM, Suchodolski JS, Fosgate GT, Hartsfield SM. Cardiac troponin I concentrations following medetomidine-butorphanol sedation in dogs. Veterinary Anaesthesia and Analgesia, 37 (4): 342-346, 2010. PMID: 20636565
Hulse D, Hyman W, Beale B, Saunders B, Peycke L, Hosgood G. Determination of isometric points for placement of a lateral suture in treatment of the cranial cruciate ligament deficient stifle. Vet Comp Orthop Trauma, 23 (3): 163-167, 2010. WOS: 000280904600015
Stratman AN, Saunders WB, Sacharidou A, Koh W, Fisher KE, Zawieja DC, Davis MJ, Davis GE. Endothelial cell lumen and vascular guidance tunnel formation requires MT1-MMP-dependent proteolysis in 3D collagen matrices. Blood, 114 (2): 237-247, 2009. PMID: 19339693
Davis GE, Saunders WB. Molecular balance of capillary tube morphogenesis versus regression: Involvement of distinct matrix metalloproteinases and their inhibitors during wound repair related events using in vitro models of granulation tissue. J Investig Dermatol Symp Proc. 11(1), 44-56, 2006.
Fisher KE, Pop A, Koh W, Anthis NJ, Saunders WB, Davis GE. Tumor cell invasion of collagen matrices requires coordinate lipid agonist-induced G-protein and membrane-type-matrix metalloproteinase-1 dependent signaling. Molecular Cancer, 5 (69): 1-23, 2006. PMID: 17156449
Saunders WB, Bohnsack BL, Faske JB, Anthis NJ, Bayless KJ, Hirschi KK, Davis GE. Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3. J Cell Biology, 175 (1): 179-191, 2006. PMID: 17030988
Kamei M, Saunders WB, Bayless KJ, Dye L, Davis GE, Weinstein BM. Endothelial tubes assemble from intracellular vacuoles in vivo. Nature, 442 (7101): 453-456, 2006. PMID: 16799567
Saunders WB, Bayless KJ, Davis GE. MMP-1 activation by serine proteases and MMP-10 (stromelysin-2) induces human capillary tubular network collapse in three-dimensional collagen matrices. J Cell Sci, 118 (10): 2325-2340, 2005. PMID: 15870107
Saunders WB, Hulse DL, Schulz KS. Evaluation of portal locations and periarticular structures in canine coxofemoral arthroscopy: a cadaver study. Vet Comp Orthop Trauma, 17 (4):184-8, 2004. WOS: 000226497400003
Saunders WB, Tobias KM. Pneumoperitoneum in the dog and cat, 39 cases (1983-2002). J Am Vet Med Assoc, 223 (4): 462-8. August 15, 2003. PMID: 12930083
Book Chapters
Saunders WB, Gregory CA, Bearden RN, McNeill E. Chapter 3: Stem cells and regenerative medicine. In: Veterinary Surgery: Small Animal. Eds: Johnston SA. Tobias KM. 2nd Edition. Elsevier, Philadelphia, PA. June, 2017.
Saunders WB, Bearden RN, Franklin SP. Chapter 4: Platelet rich plasma and autologous conditioned sera. In: Veterinary Surgery: Small Animal. Eds: Johnston SA. Tobias KM. 2nd Edition. Elsevier, Philadelphia, PA. June, 2017.
Saunders WB, Moreno M, Zambrano S, Dejardin L. Chapter 39: Bone biomechanics and fracture biology. In: Veterinary Surgery: Small Animal. Eds: Johnston SA. Tobias KM. 2nd Edition. Elsevier, Philadelphia, PA. June, 2017.
Abstracts
***Hillier TN, Atiee GF, Lawhon SD, Silveira CJ, Saunders WB. Incidence of subclinical bacteriuria (SBU) in dogs presenting for total hip replacement (THR). Submitted to the 51st Annual Symposium of the Veterinary Orthopedic Society, Lake Tahoe, NV, 2024 (Podium).
***Hollenbeck DL, Lawson ZT, Silveira CJ, Moreno MR, Robbins AB, Saunders WB. Mechanical evaluation of canine cementless total hip replacement broaches: effect of tooth design on broach and stem insertion. Submitted to the 51st Annual Symposium of the Veterinary Orthopedic Society, Lake Tahoe, NV, 2024 (Podium).
Dobson LK, Beltran FO, Gasson SB, Pfau-Cloud MR, Lawson ZT, Pool RR, Moreno MR, Grunlan MA, Saunders WB. Self-fitting shape memory polymer scaffolds (SMPs) for treatment of craniomaxillofacial defects. Presented at the One Health Day Symposium, Texas A&M School of Veterinary Medicine, Translational Science Award One Health Alliance, and the UT Southwestern CTSA Program, Dallas, TX, November 3, 2023. ***Dobson LK awarded 2nd place poster presentation.
Vasudevan L, Griffin J, Saunders WB. Overview of radiation safety considerations in the treatment of canine osteoarthritis using Sn-117m at Texas A&M University Veterinary Medical Teaching Hospital. Presented at the IRPA North American Regional Congress, February 20-24, 2022.
Peycke L, Saunders B, Hulse D. Intra-articular grafts for replacement of the CrCL deficient stifle in dogs. Presented at the World Veterinary Endoscopy and Minimally Invasive Surgery Meeting, Colorodo Springs, CO, June 28-30, 2021 (Podium).
Zderic I, Varga P, Styger U, Gueorguiev B, Drenchev L, Asimus E, Saunders B, Kowaleski M, Boudrieau RJ, Dejardin, L. Fatigue life assessment of two hybrid plate designs for canine pancarpal arthrodesis. Presented at the 26th Congress of the European Society of Biomechanics, Milan, Italy, July 11-14, 2021 (Poster).
Zderic I, Varga P, Styger U, Gueorguiev B, Drenchev L, Asimus E, Saunders B, Kowaleski M, Boudrieau RJ, Dejardin, L. In-silico and experimental deformation analysis of two hybrid plate designs for canine pancarpal arthrosesis. Presented at the 26th Congress of the European Society of Biomechanics, Milan, Italy, July 11-14, 2021 (Podium).
Jenkins D, Laverty D, Saunders B, Cosgriff-Hernandez E. Development of polyHIPE autograft extenders for improved bone regeneration. Presented at the Annual Symposium for the Society of Biomaterials. Chicago, IL, April 21-24, 2021.
Zderic I, Varga P, Styger U, Drenchev L, Gueorguiev B, Asimus E, Saunders B, Kowaleski M, Boudrieau RJ, Dejardin, L. Mechanical evaluation of two hybrid locking plate designs for canine pancarpal arthrodesis under fatigue loading. Presented at the annual symposium of the European College of Veterinary Surgeons, Virtual, Summer 2021.
Zderic I, Varga P, Styger U, Drenchev L, Gueorguiev B, Asimus E, Saunders B, Kowaleski M, Boudrieau RJ, Dejardin, L. Mechanical evaluation of two hybrid locking plate designs for canine pancarpal arthrodesis. Presented at the annual symposium of the European College of Veterinary Surgeons, Virtual, Summer 2021.
***Gasson SB, Dobson LK, Pfau M, Beltran F, Grunlan M, Saunders WB. In vitro and in vivo assessment of Poly(e-Caprolactone) and Poly(e-Caprolactone)-Poly(L-lactic acid) shape memory polymers for bone tissue engineering. Virtually presented at the Annual Symposium of the Veterinary Orthopedic Society (2021 COVID travel restrictions). Awarded best research presentation of the meeting.
***Silveira CJ, Saunders WB, McDaniel S, Patterson AP, Kerwin SC, Patterson CA, Jeffery N, Diesel AB. Evaluation of dermatologic factors associated with implant associated infection in dogs following total hip replacement. Virtually presented at the Annual Symposium of the Veterinary Orthopedic Society (2021 COVID travel restrictions).
***Silveira CJ, Saunders WB. Greater trochanter osteotomy to address medialization of the greater trochanter or chronic luxation in cementless total hip replacement. Virtually presented at the Annual Symposium of the Veterinary Orthopedic Society (2021 COVID travel restrictions).
***Gasson SB, Dobson LK, Pfau M, Beltran F, Grunlan MA, Saunders WB. Poly (e-caprolactone) and poly (e-caprolactone-poly(L-lactic acid) shape memory polymers as suitable scaffolds for in vitro osteogenesis of canine mesenchymal stromal cells. Virtually presented at the International Society for Stem Cell Research (ISSCR), Boston, MA, 2020 (COVID travel restrictions).
***Gasson SB, Dobson LK, Chow L, Dow S, Gregory CA, Saunders WB. Optimizing in vitro osteogenesis in canine autologous and iPS-derived mesenchymal stromal cells with dexamethasone and bone morphogenic protein (BMP)-2. Virtually presented at the International Society for Stem Cell Research (ISSCR), Boston, MA, 2020 (COVID travel restrictions).
***Dobson LK, Beltran F, Pfau MR, Lawson Z, Moreno MR, Grunlan MA, Saunders WB. Rat mesenchymal stromal cells (MSCs) and self-fitting shape memory polymers (SMPs) for craniomaxillofacial defects: an in vivo pilot study. Virtually presented at the International Society for Stem Cell Research (ISSCR), Boston, MA, 2020 (COVID travel restrictions).
***Dobson LK, Zeitouni S, McNeill EP, Gregory CA, Saunders WB. Canine mesenchymal stromal cell mediated bone regeneration is enhanced in the presence of sub-therapeutic concentrations of BMP-2 in a murine calvarial defect. Virtually presented at the International Society for Stem Cell Research (ISSCR), Boston, MA, 2020 (COVID travel restrictions).
***Silveira CJ, Dobson LK, Gasson SB, Saunders WB. Chondrogenesis of canine marrow stromal cells (cMSCs) in a serum-free type I collagen system is enhanced by pre-exposure to basic fibroblast growth factor (bFGF). Presented at the 47th Annual Symposium of the Veterinary Orthopedic Society, Sun Valley, ID, 2020 (Podium). Awarded the best research presentation of the 2020 meeting.
***Gasson SB, Dobson LK, Pfau M, Beltran F, Grunlan MA, Saunders WB. Poly (e-caprolactone) and poly (e-caprolactone-poly(L-lactic acid) shape memory polymers as suitable scaffolds for in vitro osteogenesis of canine mesenchymal stromal cells. Presented at the Graduate Student Association Research Symposium, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX, 2020 (Poster).
***Dobson LK, Zeitouni S, McNeill EP, Gregory CA, Saunders WB. Canine mesenchymal stromal cell mediated bone regeneration is enhanced in the presence of sub-therapeutic concentrations of BMP-2 in a murine critical-sized calvarial defect. Presented at the Graduate Student Association Research Symposium, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX, 2020 (Poster).
***Jimmerson MC, Dobson LK, Bearden RN, Saunders WB. MT1-MMP (MMP-14) is required for invasion of 3D collagen matrices by MG-63 human osteosarcoma cells. Presented at the Veterinary Student Summer Research Scholars Symposium, Texas A&M University, College Station, TX, 2019 (podium); 19th Annual Merial-NIH National Veterinary Scholars Symposium, Tufts University, North Grafton, MA, 2019 (poster).
Dhavalikar P, Salhadar K, Wilems T, Stahl D, Saunders B, Cosgriff-Hernandez E. Osteoinductive PolyHIPE scaffolds as improved bone void fillers. Presented at the annual symposium of the Society of Biomaterials, Seattle, WA, 2019.
***Soltys-Niemann EV, Dejardin LM, Dobson LK, Eichelberger BM, Kerwin SC, Gregory CA, Saunders WB. Optimizing a critical gap non-union femoral model for objective assessment of bone regeneration in dogs. Presented at the Annual Symposium of the Veterinary Orthopedic Society, Breckenridge, CO, 2019 (Podium).
***Gasson SB, Dobson LK, Chow L, Dow S, Saunders WB. In vitro osteogenesis in autologous and iPS-derived canine mesenchumal stromal cells is modulated by dexamethasone and bone morphogenic protein-2. Presented at the Annual Symposium of the Veterinary Orthopedic Society, Breckenridge, CO, 2019 (Podium).
***Gasson SB, Dobson LK, Chow L, Dow S, Saunders WB. In vitro osteogenesis in autologous and iPS-derived canine mesenchumal stromal cells is modulated by dexamethasone and bone morphogenic protein-2. Presented at the annual Graduate Student Association Research Symposium, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX, 2019 (Podium).
***Amadio A, Ruoff C, Norby B, Saunders WB. Limb alignment in Labrador Retrievers affected by elbow dysplasia: evaluation of standing versus recumbent frontal plane radiography. Presented at the SCIVAC meeting, Rimini, Italy, 2018 (Poster).
***Amadio A, Corriveau KM, Norby B, Saunders WB. Effect of proximal abducting ulnar osteotomy (PAUL) on thoracic limb alignment in a canine ex vivo simulated weight-bearing model. Presented at the SCIVAC meeting, Rimini, Italy, 2018 (Podium).
***Dobson LK, Zeitouni S, McNeill EP, Gregory CA, Saunders WB. Canine mesenchymal stem cell mediated bone regeneration is enhanced in the presence of sub-therapeutic concentrations of BMP-2 in a murine critical-sized calvarial defect. Presented at the Annual Symposium of the Veterinary Orthopedic Society, Aspen/Snowmass, CO, 2018 (Podium).
***Corriveau KM, Amadio A, Norby B, Saunders WB. Effect of proximal abducting ulnar osteotomy (PAUL) on thoracic limb alignment in a canine ex vivo simulated weight-bearing model. Presented at the Annual Symposium of the Veterinary Orthopedic Society, Aspen/Snowmass, CO, 2018 (Podium). Selected for the Mark Bloomberg resident research award. Selected as the best resident research podium presentation for the 2018 symposium.
***Maciver MM, Dobson LK, Gregory CA, Muneoka K, Saunders WB. Development of a 3D Type I collagen assay to evaluate chondrogenesis of canine bone marrow-derived mesenchymal stem cells. Presented at the Annual Symposium of the Veterinary Orthopedic Society, Aspen/Snowmass, CO, 2018 (Podium). Selected for the Mark Bloomberg resident research award.
O’Brien MT, MacIver MA, Dobson LK, Saunders WB. Histology provides essential context when characterizing chondrogenic differentiation of canine bone marrow-derived mesenchymal stem cells. Presented at the Annual Symposium of the Society for Toxicologic Pathology, Monteal, Quebec, Canada, 2017 (poster).
***Won WW, Ruoff CM, Huggins SS, Eichelberger BM, Saunders WB. Small Field of View 3T MRI to Determine Meniscal Volume in the Canine Stifle: an Ex-Vivo Study. Presented at the Annual Symposium of the Veterinary Orthopedic Society, Snowbird, UT, 2017 (podium).
***Bearden RN, O’Brien MT, Gacasan EG, Sehnert RM, Ehrhardt DA, Teixeira MW, Weeks BR, Grunlan MA, Saunders WB. Porous Poly(ethylene glycol) Diacrylate (PEG-DA) Hydrogels as Scaffolds for Articular Cartilage Tissue Engineering. Presented at the Annual Symposium of the Veterinary Orthopedic Society, Snowbird, UT, 2017 (podium).
***Young W, Stone A, Zambrano S, Breiteneicher A, Saunders WB, Hulse D, Moreno MR. An Ex Vivo Evaluation of the CBLO Using a Novel Canine Stifle Model: Considering the Physiologic Biomechanical Environment. Presented at the LAUNCH Undergraduate Research Summer Poster Session, Texas A&M University, College Station, TX, 2016 (poster).
***Young W, Stone A, Zambrano S, Breiteneicher A, Saunders WB, Hulse D, Moreno MR. An Ex Vivo Evaluation of the CBLO Using a Novel Canine Stifle Model: Considering the Physiologic Biomechanical Environment. Presented at the annual Undergraduate Student Research Week, Texas A&M University, College Station, TX, 2016 (poster).
***Bearden RN, Gacasan E, Sehnert R, Glidewell H, Ehrhardt D, Huggins SS, Grunlan MA, Saunders WB. The use of novel and traditional polyethylene glycol (PEG) hydrogels as three-dimensional (3D) scaffolds for canine articular cartilage tissue engineering. Presented at the annual Graduate Student Association Research Symposium, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX, 2016 (podium).
***Zambrano S, Teixeira MW, Lamb JL, Kerwin SC, Cummings KJ, Kowaleski MP, Moreno MR, Saunders WB. Comparison of three toggle suture constructs (TSCs) for craniodorsal hip luxation in dogs: an ex-vivo cyclical biomechanical study. Presented at the Annual Symposium of the Veterinary Orthopedic Society, Big Sky, MT, 2016 (Best Research Podium Presentation of the 2016 VOS Annual Scientific Meeting: Saunders WB).
***Breiteneicher AB, Norby B, Schulz KS, Kerwin SC, Hulse DA, Fox DB, Saunders WB. Ex-vivo effect of sliding humeral osteotomy (SHO) on thoracic limb alignment: implications for management of medial compartment disease. Presented at the Annual Symposium of the Veterinary Orthopedic Society, Big Sky, MT, 2016 (Bloomberg Resident Research Award, Breiteneicher A).
***Reeve LR, Huggins SS, Bearden RN, Carroll LM, Saunders WB. MT-MMPs mediate PDGF-BB-induced invasion of canine multipotent stromal cells (cMSCs) in 3D collagen matrices. Presented at the Veterinary Student Summer Research Scholars Symposium, Texas A&M University, College Station, TX, 2015 (podium); 15th Annual Merial-NIH National Veterinary Scholars Symposium, UC-Davis, Davis, CA, 2015 (poster).
***Ruoff CM, Eichelberger BM, Pool RR, Griffin JF, Cummings KJ, Pozzi A, Saunders WB. Narrow field of view 3T MRI identifies articular cartilage lesions in canine cadaveric stifles. Presented at the Annual Symposium of the Veterinary Orthopedic Society, Sun Valley, ID, 2015.
***Bearden RN, Huggins SS, Smith R, Gregory CA, Saunders WB. Isolation and characterization of canine multipotent stromal cells (MSCs) from bone marrow, adipose tissue, and synovium. Presented at the Annual Symposium of the Veterinary Orthopedic Society, Sun Valley, ID, 2015.
***Bearden RN, Huggins SS, Saunders WB. PDGF-BB induces MG-63 osteosarcoma cell invasion. Presented at the Annual Symposium of the Veterinary Orthopedic Society, Sun Valley, ID, 2015.
Huggins SS, Suchodolski JS, Bearden RN, Steiner JM, Saunders WB. Serum concentrations of canine interleukin-1 receptor antagonist protein (IRAP) in healthy dogs in response to an autologous serum processing system. Presented at the Annual Symposium of the Veterinary Orthopedic Society, Sun Valley, ID, 2015.
Saunders WB, Reeve LR, Bearden RN, Huggins SS, Gregory CA. PDGF-BB mediated invasion of 3D collagen gels by canine MSCs requires MT-MMPs. Presented at the Annual Symposium of the Veterinary Orthopedic Society, Sun Valley, ID, 2015.
***Zambrano S, Leidlein CR, Agrella E, Schmidt C, Saunders WB, Moreno MR. Development of a coxofemoral ambulation simulator for biomechanical evaluation of luxation reduction techniques in ex vivo canine specimens. Presented at Undergraduate Student Research Week – Aggie Research Scholars, Texas A&M University, College Station, TX, 2014 (poster).
***Bearden RN, Huggins SS, Saunders WB. Platelet derived growth factor-BB (PDGF-BB) stimulates MG-63 osteosarcoma cells to invade three-dimensional (3D) collagen matrices in a dose dependent manner by membrane-type MMPs. Presented at the Graduate Student Association Research Symposium, Texas A&M University College of Veterinary Medicine, College Station, TX, 2014 (poster).
***Gasson SB, Bearden RN, Huggins SS, Saunders WB. Effect of extracellular matrix (ECM) proteins on proliferation and osteogenic differentiation of canine marrow Multipotent Stromal Cells (cMSCs). Presented at the Veterinary Student Summer Research Scholars Symposium, Texas A&M University, College Station, TX, 2014 (podium); 14th Annual Merial-NIH National Veterinary Scholars Symposium, Cornell University, Ithaca, NY, 2014 (poster).
***Ruoff CM, Eichelberger BM, Pool RR, Griffin JF, Cummings KJ, Pozzi A, Padua A, Saunders WB. Accuracy of narrow field of view 3T MRI for identification of articular cartilage lesions in the canine stifle: an ex vivo cadaveric study. Presented at the Symposium of the American College of Veterinary Radiology, St. Lois, MO, 2014 (podium).
Leonard KC, Kowaleski MP, Saunders WB, Boudrieau RJ. Combined tibial plateau leveling osteotomy and tibial tuberosity transposition for treatment of cranial cruciate ligament rupture and medial patellar luxation. Presented at the 4th World Veterinary Orthopedic Congress, Breckenridge, CO, 2014 (podium).
***Hans EC, Saunders WB, Beale BS, Hulse DA. Arthroscopic diagnosis and treatment of medial coronoid disease (MCD) in toy and small breed dogs: 13 elbows (2000-2012). Presented at the Annual Summit, American College of Veterinary Surgeons, San Antonio, TX, 2013 (podium).
***Kaufman K, Saunders WB, Beale BS, Thames H. Arthroscopic evaluation of the articular cartilage and osteoarthritic changes in cranial cruciate deficient dogs with or without bucket handle tear of the medial meniscus. Presented at the Annual Summit, American College of Veterinary Surgeons, San Antonio, TX, 2013 (podium, resident research symposium).
Davis CA, Baker ST, Bonin GA, Hilebrandt AA, Hulse DA, Kerwin SC, Saunders WB, Moreno MR. Evaluating veterinary orthopedic implants: a comparative study of LC-DCP/rod and CRIF/rod fixation. Presented at the Annual Meeting of the Biomedical Engineering Society (BMES), Seattle, WA, 2013 (poster).
Leidlein CR, Agrella E, Sandler JS, Zambrano S, Saunders WB, Moreno MR. Development of an ambulation simulator for biomechanical evaluation of modified toggle rod stabilization techniques for traumatic hip luxations: an ex vivo canine study. Presented at Undergraduate Engineering Symposium – Aggie Research Scholars, Texas A&M University, College Station, TX, 2013 (poster).
Saunders WB, Bonin GA, Baker ST, Davis CA, Hildebrandt AA, Hulse DA, Kerwin SC, Moreno MR. Biomechanical analysis of 5 mm clamp rod internal fixator/intramedullary rod and 3.5 mm limited contact-dynamic compression plate/intramedullary rod constructs under bending or torsional loads in a canine femoral gap model. Presented at the Annual Symposium, American College of Veterinary Surgeons, San Antonio, TX, 2013 (podium).
Saunders WB, Bonin GA, Baker ST, Hildebrandt A, Hulse DA, Kerwin SC, Moreno MR. Torsional Analysis of 5 mm Clamp Rod Internal Fixator/Intramedullary Rod and 3.5 mm Limited Contact Dynamic Compression Plate/Intramedullary Rod Constructs in a Canine Femoral Gap Model. Presented at the Annual Symposium of the Veterinary Orthopedic Society, the Canyons, UT, 2013 (poster).
Saunders WB, Goodrich ZG, Norby B, Eichelberger BM, Friedeck WO, Callis HN, Hulse DA, Kerwin SC, Fox DB. Evaluation of thoracic limb alignment in healthy labrador retrievers using recumbent versus standing view frontal plane radiography and the center of rotation of angulation (CORA) methodology. Presented at the Annual Symposium of the Veterinary Orthopedic Society, the Canyons, UT, 2013 (podium).
***Bonin GA, Baker ST, Hildebrandt A, Hulse DA, Kerwin SC, Moreno MR, Saunders WB. Torsional analysis of 5 mm Clamp Rod Internal Fixator/Intramedullary rod and 3.5 mm Limited Contact Dynamic Compression Plate/Intramedullary rod constructs in a canine femoral gap model. Accepted for podium presentation, American College of Veterinary Surgeons Annual Summit, Washington D.C., 2012 (meeting cancelled due to weather).
***Goodrich ZJ, Norby B, Eichelberger BM, Hulse DA, Kerwin SK, Fox DB, Saunders WB. Evaluation of thoracic limb alignment in healthy Labrador Retrievers using recumbent versus standing view frontal plane radiography and the Center of Rotation of Angulation (CORA) methodology. Accepted for podium presentation, American College of Veterinary Surgeons Annual Summit, Washington D.C., 2012 (meeting cancelled due to weather).
***Scholl JL, Huggins SS, Gregory CA, Saunders WB. Optimized culture conditions for enhanced osteogenic differentiation of canine mesenchymal stem cells. Presented at the Veterinary Student Summer Research Scholars Symposium, Texas A&M University, College Station, TX, 2012 (podium); 12th Annual Merial-NIH National Veterinary Scholars Symposium, Colorado State University, Ft. Collins, CO, 2012 (poster).
***Cochran JM, Bayless KJ, Huggins SS, Saunders WB. Lysophosphatidic acid (LPA) stimulates MG-63 osteosarcoma cells to invade three-dimensional (3D) collagen matrices in an MT-MMP dependent manner. Undergraduate Summer Research Symposium, Texas A&M University Health Science Center, College Station, TX, 2011 (poster).
Johnston J, Kerwin SC, Saunders WB, Levine J, Witsberger T, Carroll G, Fajt V. Administration and timing of perioperative cefazolin in a veterinary teaching hospital. Presented at the Summer Veterinary Student Research Fellowship Conference, Texas A&M University, College Station, TX, 2010 (podium); 10th Annual Merial-NIH National Veterinary Scholars Symposium, University of Georgia, Athens, GA 2010 (poster).
Witsberger T, Hulse D, Kerwin S, Saunders WB. Minimally invasive application of a plate-rod construct for fractures of the radius and ulna: technique and case series. Veterinary Orthopedic Society, Breckenridge, CO, 2010.
Koh W, Faske JB, Saunders WB, Davis GE. Cdc42 and its downstream effectors control endothelial cell invasion and lumenal morphogenesis in 3D collagen matrices. Experimental Biology, San Francisco, CA, 2006.
Mareth AK, Saunders WB, Faske JB, Forough R, Davis GE. Blockade of endothelial cell invasion and tubular morphogenesis using siRNA directed to integrin alpha chains and basement membrane matrix proteins. Experimental Biology, San Francisco, CA, 2006.
Fisher KE, Koh W, Saunders WB, Davis GE. Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) regulate tumor cell invasion of three-dimensional collagen matrices via coordinated activation of EDG1/S1P1, EDG2/LPA1, and membrane type-1 matrix metalloproteinase (MT1-MMP). Amercian Association of Cancer Research (AACR), Washington D.C., 2006.
Saunders WB, Bayless KJ, Bohnsack BL, Faske JB, Anthis NJ, Hirschi KK, Davis GE. Endothelial cell (EC)-derived TIMP-2 and pericyte-derived TIMP-3 control vascular stabilization events by targeting of EC membrane metalloproteinases and the secreted MMPs, MMP-1 and MMP-10. NAVBO Developmental Vascular Biology Workshop II, Monterrey, CA, 2006.
Davis GE, Koh W, Mareth AK, Faske JB, Fisher KE, Saunders WB. Molecular control of capillary lumen formation in three-dimensional collagen matrices involves coordinate regulation of Cdc42, integrin α2β1 and membrane type-metallloproteinase-1. NAVBO Developmental Vascular Biology Workshop II, Monterrey, CA, 2006.
Kamei M, Saunders WB, Bayless KJ, Davis GE, Weinstein BM. The endothelial lumenization in vivo occurs through the process of vacuolarization in zebrafish Danio rerio. NAVBO Developmental Vascular Biology Workshop II, Monterrey, CA, 2006.
Davis GE, Saunders WB. Matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) regulate a molecular balance of capillary tube morphogenesis versus regression during wound repair. Montagna Wound Healing Symposium, Portland, OR, 2005.
Davis GE, Saunders WB. Membrane-type metalloproteinases (MT-MMPs) are required for capillary lumen formation in three-dimensional collagen matrices. Gordon Conference on Metalloproteinases, Big Sky, MT, 2005.
Saunders WB, Davis GE. Wild-type and spontaneously active matrix metalloproteinase (MMP)-1 mutants induce vascular regression in vitro and in vivo. American Society for Cell Biology, San Francisco, CA, 2005.
Kamei M, Saunders WB, Bayless KJ, Davis GE, Weinstein BM. The endothelial lumenization in vivo occurs through the process of vacuolarization in zebrafish Danio rerio. American Society for Cell Biology, San Francisco, CA, 2005.
Saunders WB, Davis GE. Human matrix metalloproteinase (MMP)-1 is a vascular regression factor: activation of MMP-1 by multiple serine proteases and MMP-10 induces vascular regression in vitro and in vivo. TAMUS-HSC GSO Research Symposium, College Station, TX, 2005.
Fisher KE, Pop A, Koh W, Anthis NJ, Bayless KJ, Saunders WB, Davis GE. Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) markedly regulate tumor cell migration and invasion of three-dimensional collagen matrices. TAMUS-HSC GSO Research Symposium, College Station, TX, 2005.
Davis GE, Saunders WB, Anthis NJ, Bayless KJ. Matrix metalloproteinases-1 and -10 control capillary tube regression and the pericyte-derived proteinase inhibitor, TIMP-3, blocks these events to stabilize capillary tubes. Experimental Biology, San Diego, CA, 2005.
Saunders WB, Bayless KJ, Davis GE. Serine protease and stromelysin-2 (MMP-10) mediated activation of matrix metalloproteinase-1 (MMP-1) induces extracellular matrix (ECM) proteolysis and capillary tube regression in three-dimensional collagen matrices. American Society for Cell Biology, Washington D.C., 2004.
Bayless KJ, Bohnsack BE, Anthis NJ, Saunders WB, Hirschi KK, Davis GE. TIMP-3 inhibits three-dimensional morphogenesis of endothelial cells in vitro and vasculogenesis in vivo: role for TIMP-3 in stabilizing vascular networks. American Society for Cell Biology, Washington D.C., 2004.
Davis GE, Saunders WB, Anthis JN, Bayless KJ. Molecular control of endothelial cell tube formation, stabilization, and regression by matrix metalloproteinases and pericyte-derived proteinase inhibitors. American Society for Matrix Biology, San Diego, CA, 2004.
Saunders WB, Bayless KJ, Davis GE. Activation of matrix metalloproteinase-1 (MMP-1) by serine proteases induces extracellular matrix (ECM) proteolysis and capillary tube regression in three-dimensional collagen matrices. TAMU-HSC Graduate Student Organization Symposium, February 18, 2004.
Saunders WB, Bayless KJ, Davis GE. Activation of matrix metalloproteinase-1 (MMP-1) by serine proteases induces extracellular matrix (ECM) proteolysis and capillary tube regression in three-dimensional collagen matrices. Matrix Remodeling in Pathology, Experimental Biology, Washington D.C., 2004.
Neiger J, Saunders B, Hu J, et. al. Temporal and spatial modulation of Enos mRNA levels in an aortic coarctation model of hypertension. TAMU-HSC Graduate Student Organization Symposium, February 18, 2004.
Neiger J, Saunders B, Hu J, et. al. Temporal and spatial modulation of Enos mRNA levels in an aortic coarctation model of hypertension. Experimental Biology, Washington D.C., 2004.
Bayless KJ, Saunders WB, Davis GE. Molecular regulation of capillary lumen stability and regression in three-dimensional matrices. Keystone Symposia, Santa Fe, NM, 2004.
Davis GE, Saunders WB, Bayless KJ. Matrix metalloproteinase-1 is induced during capillary tubular morphogenesis to control vascular tube regression events in three-dimensional collagen matrices. NAVBO Developmental Vascular Biology Workshop II, Monterrey, CA, 2004.
Hulse DA, Hyman W, Saunders WB. Strain analysis of femoral and tibial anchorage sites for extra-articular reconstruction of the cranial cruciate deficient stifle joint. Veterinary Orthopedic Society, Lake Louise, Canada, February 2001.