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W. Les Dees

Professor Emeritus


Mailstop: 4458

Department: VIBS

Photo of Dees, W. Les


  • Post-Doc Neuroendocrinology, University of Texas - Southwestern Medical Center 1986
  • Ph.D. Anatomy, Texas A&M University 1982
  • M.S. Reproductive Physiology, Texas A&M University 1979
  • B.S. Biomedical Sciences, Texas A&M University 1972
  • B.S. Animal Science, Texas A&M University 1971


  • Toxicology
  • Neuroscience

Interdisciplinary Activities

  • Neuroscience
  • Toxicology
  • Reproductive Biology

Scholarly Interests

Factors controlling or altering the onset of female puberty.


Manganese stimulated kisspeptin is mediated by the IGF-1/Akt/mTOR pathway.
Srivastava VK, JK Hiney, WL Dees
Endocrinology. 2016
Manganesse protects against the effects of alcohol on hypothalamic puberty-related hormones.
Hiney JK, VK Srivastava, WL Dees
Life Sciences. 2016
Alcohol alters hypothalamic glial-neuronal communications involved in the neuroendocrine control of puberty: In vivo and in vitro assessments.
Dees WL, Hiney JK, Srivastava VK
Alcohol. 2015
Differential effects of alcohol on excitatory and inhibitory puberty-related peptides in the basal hypothalamus of the female rat.
Srivastava VK, JK Hiney, K Stevener, WL Dees
Alc: Clin Exp Res. 2015
Alcohol alters IGF-1 and transforming growth factor beta1 synthesis in the medial basal hypothalamus of the prepubertal female rat.
Hiney JK, Srivastava VK, Dees WL
Alc: Clin. Exp. Res. 2014
Improvement in in vitro fertilization outcome following in vivo synchronization of oocyte maturation in mice.
Taiyeb AM, Muhsen-Alanssari SA, Dees W, Ridha-Albarzanchi MT, Kraemer DC
Exp Biol Med (Maywood). 2014
Host neuro- immuno-endocrine responses in periodontal disease.
Rettori E, De Laurentiis A, Dees WL, Endruhn A, Rettori V
Curr Pharm Des. 2014 20(29):4749-59.
Prepubertal exposure to elevated manganese results in estradiol regulated mammary gland ductal differentiation and hyperplasia in female rats.
Dearth RK, Hiney JK, Srivastava VK, Hamilton AM, Dees WL
Exp Biol Med (Maywood). 2014 239(7):871-882.
Cilostazol administered to female mice induces ovulation of immature oocytes: a contraceptive animal model.
Taiyeb AM, Ridha MT, Sayes CM, Dees WL, Kraemer DC
Life Sci. 2014 96(1-2):46-52.
In vitro effects of cilostazol, a phosphodiesterase 3A inhibitor, on mouse oocyte maturation and morphology.
Taiyeb AM, Dees WL, Ridha-Albarzanchi MT, Sayes CM, Kraemer DC
Clin Exp Pharmacol Physiol. 2014 41(2):147-53.
Cilostazol blocks pregnancy in naturally cycling mice.
Albarzanchi AM, Sayes CM, Ridha Albarzanchi MT, Fajt VR, Dees WL, Kraemer DC
Contraception. 2013 87(4):443-8.
Parity-induced decrease in systemic growth hormone alters mammary gland signaling: a potential role in pregnancy protection from breast cancer.
Dearth RK, Delgado DA, Hiney JK, Pathiraja T, Oesterreich S, Medina D, Dees WL, Lee AV
Cancer Prev Res (Phila). 2010 3(3):312-21.
Actions and interactions of alcohol and insulin-like growth factor-1 on female pubertal development.
Dees WL, Srivastava V, Hiney JK
Alcohol Clin Exp Res. 2009 33(11):1847-56.
Acute effect of manganese on hypothalamic luteinizing hormone releasing hormone secretion in adult male rats: involvement of specific neurotransmitter systems.
Prestifilippo JP, Fernández-Solari J, De Laurentiis A, Mohn CE, de la Cal C, Reynoso R, Dees WL, Rettori V
Toxicol Sci. 2008 105(2):295-302.
Effect of manganese on luteinizing hormone-releasing hormone secretion in adult male rats.
Prestifilippo JP, Fernández-Solari J, Mohn C, De Laurentiis A, McCann SM, Dees W, Rettori V
Toxicol Sci. 2007 97(1):75-80.
Origin and ontogeny of mammalian ovarian neurons.
Dees WL, Hiney JK, McArthur NH, Johnson GA, Dissen GA, Ojeda SR
Endocrinology. 2006 147(8):3789-96.
Lipopolysaccharide-induced leptin synthesis and release are differentially controlled by alpha-melanocyte-stimulating hormone.
Mastronardi CA, Srivastava V, Yu WH, Dees WL, McCann SM
Neuroimmunomodulation. 2005 12(3):182-8.
Alcohol alters luteinizing hormone secretion in immature female rhesus monkeys by a hypothalamic action.
Dissen GA, Dearth RK, Scott HM, Ojeda SR, Dees WL
Endocrinology. 2004 145(10):4558-64.
Influence of estradiol on insulin-like growth factor-1-induced luteinizing hormone secretion.
Hiney JK, Srivastava V, Dearth RK, Dees WL
Brain Res. 2004 1013(1):91-7.
Intrinsic neurons in the mammalian ovary.
D'Albora H, Anesetti G, Lombide P, Dees WL, Ojeda SR
Microsc Res Tech. 2002 59(6):484-9.
Lamprey GnRH-III acts on its putative receptor via nitric oxide to release follicle-stimulating hormone specifically.
Yu WH, Karanth S, Mastronardi CA, Sealfon S, Dean C, Dees WL, McCann SM
Exp Biol Med (Maywood). 2002 227(9):786-93.
Hypothalamic control of gonadotropin secretion.
McCann SM, Karanth S, Mastronardi CA, Dees WL, Childs G, Miller B, Sower S, Yu WH
Prog Brain Res. 2002 141(141):151-64.
Lipopolysaccharide-induced leptin release is neurally controlled.
Mastronardi CA, Yu WH, Srivastava VK, Dees WL, McCann SM
Proc Natl Acad Sci U S A. 2001 98(25):14720-5.
Control of gonadotropin secretion by follicle-stimulating hormone-releasing factor, luteinizing hormone-releasing hormone, and leptin.
McCann SM, Karanth S, Mastronardi CA, Dees WL, Childs G, Miller B, Sower S, Yu WH
Arch Med Res. 2001 32(6):476-85.
Lamprey gonadotropin-releasing hormone-III selectively releases follicle stimulating hormone in the bovine.
Dees WL, Dearth RK, Hooper RN, Brinsko SP, Romano JE, Rahe H, Yu WH, McCann SM
Domest Anim Endocrinol. 2001 20(4):279-88.
Alcohol and female puberty: the role of intraovarian systems.
Dees WL, Srivastava VK, Hiney JK
Alcohol Res Health. 2001 25(4):271-5.
Neurotrophins and the neuroendocrine brain: different neurotrophins sustain anatomically and functionally segregated subsets of hypothalamic dopaminergic neurons.
Berg-von der Emde K, Dees WL, Hiney JK, Hill DF, Dissen GA, Costa ME, Moholt-Siebert M, Ojeda SR
J Neurosci. 1995 15(6):4223-37.
Induction by cytokines of the pattern of pituitary hormone secretion in infection.
McCann SM, Karanth S, Kamat A, Dees WL, Lyson K, Gimeno M, Rettori V
Neuroimmunomodulation. 1994 1(1):2-13.
Role of nitric oxide in the control of luteinizing hormone-releasing hormone release in vivo and in vitro.
Rettori V, Belova N, Dees WL, Nyberg CL, Gimeno M, McCann SM
Proc Natl Acad Sci U S A. 1993 90(21):10130-4.
Evidence that somatostatin is localized and synthesized in lymphoid organs.
Aguila MC, Dees WL, Haensly WE, McCann SM
Proc Natl Acad Sci U S A. 1991 88(24):11485-9.
Functional recovery of the developing rat ovary after transplantation: contribution of the extrinsic innervation.
Lara HE, Dees WL, Hiney JK, Dissen GA, Rivier C, Ojeda SR
Endocrinology. 1991 129(4):1849-60.
Expression of beta-nerve growth factor in cultured cells derived from the hypothalamus and cerebral cortex.
Gonzalez D, Dees WL, Hiney JK, Ojeda SR, Saneto RP
Brain Res. 1990 511(2):249-58.
Ethanol alters vasoactive intestinal peptide-induced steroid release from immature rat ovaries in vitro.
Dees WL, Hiney JK, Fuentes F, Forrest DW
Life Sci. 1990 46(3):165-72.
Effects of ethanol during the onset of female puberty.
Dees WL, Skelley CW
Neuroendocrinology. 1990 51(1):64-9.
Influence of ethanol on growth hormone secretion in adult and prepubertal female rats.
Dees WL, Skelley CW, Rettori V, Kentroti MS, McCann SM
Neuroendocrinology. 1988 48(5):495-9.
Detrimental effects of short-term ethanol exposure on reproductive function in the female rat.
Rettori V, Skelley CW, McCann SM, Dees WL
Biol Reprod. 1987 37(5):1089-96.
Biochemical and immunocytochemical characterization of neuropeptide Y in the immature rat ovary.
McDonald JK, Dees WL, Ahmed CE, Noe BD, Ojeda SR
Endocrinology. 1987 120(5):1703-10.
Evidence for the existence of substance P in the prepubertal rat ovary. II. Immunocytochemical localization.
Dees WL, Kozlowski GP, Dey R, Ojeda SR
Biol Reprod. 1985 33(2):471-6.
Effects of castration and ethanol on amygdaloid substance P immunoreactivity.
Dees WL, Kozlowski GP
Neuroendocrinology. 1984 39(3):231-5.
Intragastric cannulation as a method of ethanol administration for neuroendocrine studies.
Dees WL, Skelley CW, Kozlowski GP
Alcohol. 1984 1(3):177-80.
Immunocytochemistry for LHRH neurons in the arcuate nucleus area of the rat: fact or artifact?
Kozlowski GP, Dees WL
J Histochem Cytochem. 1984 32(1):83-91.
Quantitative and qualitative effects of ethanol on the LHRH-LH axis of the rat.
Dees WL, Kozlowski GP
Peptides. 1984 5(Suppl 1):209-13.
Effects of ethanol on rat hypothalamic luteinizing hormone releasing hormone. A study utilizing radioimmunoassay.
Dees WL, Mc Arthur NH, Farr KL, Culler MD, Harms PG
Biol Reprod. 1983 28(5):1066-70.
Inhibition of the postovariectomy depletion of hypothalamic luteinizing hormone releasing hormone (LHRH) by suckling.
Culler MD, McArthur NH, Dees WL, Owens RE, Harms PG
Biol Reprod. 1982 26(4):633-9.
Immunocytochemical evidence that suckling inhibits the postovariectomy depletion of median eminence luteinizing hormone releasing hormone.
Culler MD, McArthur NH, Dees WL, Owens RE, Harms PG
Neuroendocrinology. 1982 34(4):258-64.
GnRH localization in the equine brain and infundibulum: an immunohistochemical study.
Dees WL, Sorensen AM Jr, Kemp WM, McArthur NH
Brain Res. 1981 208(1):123-34.
Immunohistochemical localization of gonadotropin-releasing hormone (GnRH) in the brain and infundibulum of the sheep.
Dees WL, Sorensen AM Jr, Kemp WM, McArthur NH
Cell Tissue Res. 1981 215(1):181-91.
Comparison of four kits for enzymatic determination of ethanol in blood.
Redetzki HM, Dees WL
Clin Chem. 1976 22(1):83-6.
Influence of potassium chloride on alcohol absorption.
Redetzki HM, Dees WL, Maddox JH
Life Sci. 1974 15(12):2145-56.
Influences of manganese of female puberty
Dees WL, Hiney JK, Srivastava VK

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