Neuroscience

Program Overview

NeuroscienceCVM neuroscientists are conducting cutting-edge, integrative basic and translational research with clinical relevance, including studying mechanisms by which environmental factors interact with the genetic background to induce neurological diseases.

Research areas range from whole animal behavior to the cellular, epigenetic and genetic levels. The unique combination of strong research and teaching, the presence of clinical neurology and expertise in neuropathology, along with multiple core research laboratories at the CVM, allow this group to be uniquely placed to advance our knowledge base in mechanisms of neurological disease.

Basic Neuroscience Research

  • intracellular signaling network at both post-transcriptional and post-translational levels
  • ion channel properties and function
  • synaptic plasticity
  • neuroimmunology
  • glial biology
  • myelination
  • interactions between neurons and glia

Neurodevelopmental Disorder Research

  • Angelman
  • Prader-Willi and Turner syndromes
  • fetal alcohol spectrum disorders (FASD)
  • ataxia-telangiectasia
  • autism
  • cerebral palsy
  • epilepsy
  • hereditary neuronal system degeneration
  • neurofibromatosis

Neurological Disease Research

 

Neurodegenerative/neuro-oncological diseases/neurotrauma:

  • Alzheimer’s disease
  • meningoencephalomyelitis
  • multiple sclerosis
  • macular degeneration
  • neuromuscular diseases
  • Parkinson’s disease
  • spinal cord injury
  • tumors of the nervous system.

Infectious diseases of the nervous system, induced by retroviruses and picornaviruses, are also under investigation, as well as the role of psychological stress in susceptibility to diseases of the nervous system.

Neurotoxicology Research

  • impact of environmental toxicants on neural development
  • neurodegenerative diseases and the onset of puberty
  • neuroepigenetics

Toxicants under investigation:

  • lead
  • mercury
  • cadmium
  • manganese
  • organophosphorous compounds
  • alcohol