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Candice Brinkmeyer-Langford

Candice Brinkmeyer-Langford

Research Assistant Professor Department of Veterinary Integrative Biosciences
Contact
CBrinkmeyer@cvm.tamu.edu
9798456780
TAMU Mailstop: 4458

Research and Scholarly Interests

My primary research focus is genomics. I am particularly interested in comparative genomics: learning about the dynamics underlying human diseases by studying their counterparts in animals. One of the goals of my research is to identify and characterize environmental and genetic interactions that contribute to neurological conditions resulting from antecedent viral infections. I am particularly interested in identifying how genetic background influences disease diversity following infection by a neurotropic virus. This research is expected to increase knowledge about virally-influenced complex neurological conditions in humans and ultimately lead to the development of novel predictive models.

EDUCATION

  • Bachelor of Science in Genetics, Texas A&M University, 2002
  • Ph.D. in Genetics, Texas A&M University, 2006
  • Immunology
  • Neuroscience
  • Genomics
  • Genetics
  • Candice Brinkmeyer-Langford, Candice Chu, Cynthia Balog-Alvarez, Xue Yu, James J Cai, Mary Nabity, Joe N Kornegay (2018). Expression profiling of disease progression in canine model of Duchenne muscular dystrophy. PLOS ONE. 3, e0194485
  • Brinkmeyer-Langford C, Raudsepp T, Gustafson-Seabury A, Chowdhary BP. (2008). A BAC contig map over the proximal approximately 3.3 Mb region of horse chromosome 21. CYTOGENET GENOME RES.. 1-2, 164-72
  • Raudsepp T, Lee EJ, Kata SR, Brinkmeyer C, Mickelson JR, Skow LC, Womack JE, Chowdhary BP. (2004). Exceptional conservation of horse-human gene order on X chromosome revealed by high-resolution radiation hybrid mapping. PROC NATL ACAD SCI U S A.. 8, 2386-91
  • Brinkmeyer-Langford C, Raudsepp T, Lee EJ, Goh G, Schäffer AA, Agarwala R, Wagner ML, Tozaki T, Skow LC, Womack JE, Mickelson JR, Chowdhary BP (2005). A high-resolution physical map of equine homologs of HSA19 shows divergent evolution compared with other mammals. MAMM GENOME. 8, 631-49
  • Kornegay JN, Spurney CF, Peter P. Nghiem PP, Brinkmeyer-Langford CL, Hoffman EP, Nagaraju K (2014). Pharmacologic Management of Duchenne Muscular Dystrophy: Target Identification and Preclinical Trials INSTITUTE FOR LABORATORY ANIMAL RESEARCH JOURNAL. 1, 119-49
  • Wang G, Yang E, Mandhan I, Brinkmeyer-Langford CL, Cai JJ (2014). Population-level expression variability of mitochondrial DNA-encoded genes in humans EUROPEAN JOURNAL OF HUMAN GENETICS. 9, 1093-9
  • Bovine Genome Sequencing and Analysis Consortium (2009). The genome sequence of taurine cattle: a window to ruminant biology and evolution. SCIENCE. 5926, 522-8
  • Brinkmeyer-Langford C, Kornegay JN (2013). Comparative Genomics of X-linked Muscular Dystrophies: The Golden Retriever Model. CURR GENOMICS. 5, 330-42
  • Brinkmeyer-Langford CL, Cai JJ, Gill CA, Skow LC (2013). Microsatellite variation in the equine MHC. ANIM GENET. 3, 267-75
  • Brinkmeyer-Langford CL, Murphy WJ, Childers CP, Skow LC (2010). A conserved segmental duplication within ELA. ANIM GENET. Suppl 2, 186-95
  • Wagner ML, Raudsepp T, Goh G, Agarwala R, Schaffer AA, Dranchak PK, Brinkmeyer-Langford C, Skow LC, Chowdhary BP, Mickelson JR (2006). A 1.3-Mb interval map of equine homologs of HSA2. CYTOGENET GENOME RES.. 3-4, 227-34
  • Zeng Y, Wang G, Yang E, Ji G, Brinkmeyer-Langford CL, Cai JJ (2015). Aberrant gene expression in humans. PLOS GENET. 1,
  • Kornegay JN, Spurney CF, Nghiem PP, Brinkmeyer-Langford CL, Hoffman EP, Nagaraju K (2014). Pharmacologic management of Duchenne muscular dystrophy: target identification and preclinical trials. ILAR J. 1, 119-49
  • Fritz KL, Kaese HJ, Valberg SJ, Hendrickson JA, Rendahl AK, Bellone RR, Dynes KM, Wagner ML, Lucio MA, Cuomo FM, Brinkmeyer-Langford CL, Skow LC, Mickelson JR, Rutherford MS, McCue ME (2014). Genetic risk factors for insidious equine recurrent uveitis in Appaloosa horses. ANIM GENET. 3, 392-9
  • Wang G, Yang E, Brinkmeyer-Langford CL, Cai JJ (2014). Additive, epistatic, and environmental effects through the lens of expression variability QTL in a twin cohort. GENETICS. 2, 413-25
  • Brinkmeyer-Langford C, Rodrigues A, Kochan KJ, Haney R, Rassu F, Steelman AJ, Young C, Riggs P, Storts R, Meagher MW, Welsh CJ (2014). Consequences of perinatal bisphenol A exposure in a mouse model of multiple sclerosis. AUTOIMMUNITY. 1, 57-66
  • Brinkmeyer-Langford CL, Childers CP, Fritz KL, Gustafson-Seabury AL, Cothran M, Raudsepp T, Womack JE, Skow LC (2009). A high resolution RH map of the bovine major histocompatibility complex. BMC GENOMICS. 10, 182
  • Raudsepp T, Gustafson-Seabury A, Durkin K, Wagner ML, Goh G, Seabury CM, Brinkmeyer-Langford C, Lee EJ, Agarwala R, Stallknecht-Rice E, Schäffer AA, Skow LC, Tozaki T, Yasue H, Penedo MC, Lyons LA, Khazanehdari KA, Binns MM, MacLeod JN, Distl O, Guérin G, Leeb T, Mickelson JR, Chowdhary BP (2008). A 4,103 marker integrated physical and comparative map of the horse genome. CYTOGENET GENOME RES. 1, 28-36
  • Wagner ML, Raudsepp T, Goh G, Agarwala R, Schaffer AA, Dranchak PK, Brinkmeyer-Langford C, Skow LC, Chowdhary BP, Mickelson JR (2006). A 1.3-Mb interval map of equine homologs of HSA2. CYTOGENET GENOME RES. 3-4, 227-34
  • Bovine Genome Sequencing and Analysis Consortium, Elsik CG, Tellam RL, Worley KC, Gibbs RA, Muzny DM, Weinstock GM, Adelson DL, Eichler EE, Elnitski L, Guigó R, Hamernik DL, Kappes SM, Lewin HA, Lynn DJ, Nicholas FW, Reymond A, Rijnkels M, Skow LC, Zdobnov EM, Schook L, Womack J, Alioto T, Antonarakis SE, Astashyn A, Chapple CE, Chen HC, Chrast J, Câmara F, Ermolaeva O, Henrichsen CN, Hlavina W, Kapustin Y, Kiryutin B, Kitts P, Kokocinski F, Landrum M, Maglott D, Pruitt K, Sapojnikov V, Searle SM, Solovyev V, Souvorov A, Ucla C, Wyss C, Anzola JM, Gerlach D, Elhaik E, Graur D, Reese JT, Edgar RC, McEwan JC, Payne GM, Raison JM, Junier T, Kriventseva EV, Eyras E, Plass M, Donthu R, Larkin DM, Reecy J, Yang MQ, Chen L, Cheng Z, Chitko-McKown CG, Liu GE, Matukumalli LK, Song J, Zhu B, Bradley DG, Brinkman FS, Lau LP, Whiteside MD, Walker A, Wheeler TT, Casey T, German JB, Lemay DG, Maqbool NJ, Molenaar AJ, Seo S, Stothard P, Baldwin CL, Baxter R, Brinkmeyer-Langford CL, Brown WC, Childers CP, Connelley T, Ellis SA, Fritz K, Glass EJ, Herzig CT, Iivanainen A, Lahmers KK, Bennett AK, Dickens CM, Gilbert JG, Hagen DE, Salih H, Aerts J, Caetano AR, Dalrymple B, Garcia JF, Gill CA, Hiendleder SG, Memili E, Spurlock D, Williams JL, Alexander L, Brownstein MJ, Guan L, Holt RA, Jones SJ, Marra MA, Moore R, Moore SS, Roberts A, Taniguchi M, Waterman RC, Chacko J, Chandrabose MM, Cree A, Dao MD, Dinh HH, Gabisi RA, Hines S, Hume J, Jhangiani SN, Joshi V, Kovar CL, Lewis LR, Liu YS, Lopez J, Morgan MB, Nguyen NB, Okwuonu GO, Ruiz SJ, Santibanez J, Wright RA, Buhay C, Ding Y, Dugan-Rocha S, Herdandez J, Holder M, Sabo A, Egan A, Goodell J, Wilczek-Boney K, Fowler GR, Hitchens ME, Lozado RJ, Moen C, Steffen D, Warren JT, Zhang J, Chiu R, Schein JE, Durbin KJ, Havlak P, Jiang H, Liu Y, Qin X, Ren Y, Shen Y, Song H, Bell SN, Davis C, Johnson AJ, Lee S, Nazareth LV, Patel BM, Pu LL, Vattathil S, Williams RL Jr, Curry S, Hamilton C, Sodergren E, Wheeler DA, Barris W, Bennett GL, Eggen A, Green RD, Harhay GP, Hobbs M, Jann O, Keele JW, Kent MP, Lien S, McKay SD, McWilliam S, Ratnakumar A, Schnabel RD, Smith T, Snelling WM, Sonstegard TS, Stone RT, Sugimoto Y, Takasuga A, Taylor JF, Van Tassell CP, Macneil MD, Abatepaulo AR, Abbey CA, Ahola V, Almeida IG, Amadio AF, Anatriello E, Bahadue SM, Biase FH, Boldt CR, Carroll JA, Carvalho WA, Cervelatti EP, Chacko E, Chapin JE, Cheng Y, Choi J, Colley AJ, de Campos TA, De Donato M, Santos IK, de Oliveira CJ, Deobald H, Devinoy E, Donohue KE, Dovc P, Eberlein A, Fitzsimmons CJ, Franzin AM, Garcia GR, Genini S, Gladney CJ, Grant JR, Greaser ML, Green JA, Hadsell DL, Hakimov HA, Halgren R, Harrow JL, Hart EA, Hastings N, Hernandez M, Hu ZL, Ingham A, Iso-Touru T, Jamis C, Jensen K, Kapetis D, Kerr T, Khalil SS, Khatib H, Kolbehdari D, Kumar CG, Kumar D, Leach R, Lee JC, Li C, Logan KM, Malinverni R, Marques E, Martin WF, Martins NF, Maruyama SR, Mazza R, McLean KL, Medrano JF, Moreno BT, Moré DD, Muntean CT, Nandakumar HP, Nogueira MF, Olsaker I, Pant SD, Panzitta F, Pastor RC, Poli MA, Poslusny N, Rachagani S, Ranganathan S, Razpet A, Riggs PK, Rincon G, Rodriguez-Osorio N, Rodriguez-Zas SL, Romero NE, Rosenwald A, Sando L, Schmutz SM, Shen L, Sherman L, Southey BR, Lutzow YS, Sweedler JV, Tammen I, Telugu BP, Urbanski JM, Utsunomiya YT, Verschoor CP, Waardenberg AJ, Wang Z, Ward R, Weikard R, Welsh TH Jr, White SN, Wilming LG, Wunderlich KR, Yang J, Zhao FQ (2009). The genome sequence of taurine cattle: a window to ruminant biology and evolution. SCIENCE. 5926, 522-8
  • Candice P Chu, Jessica A Hokamp, Rachel E Cianciolo, Alan R Dabney, Candice Brinkmeyer-Langford, George E Lees, Mary B Nabity (2018). RNA-seq of serial kidney biopsies obtained during progression of chronic kidney disease from dogs with X-linked hereditary nephropathy. SCIENTIFIC REPORTS. 1, 16776
  • Candice L Brinkmeyer-Langford, Raquel Rech, Katia Amstalden, Kelli J Kochan, Andrew E Hillhouse, Colin Young, C Jane Welsh, David W Threadgill (2017). Host genetic background influences diverse neurological responses to viral infection in mice. SCIENTIFIC REPORTS. 1, 12194
  • Larry W Markham, Candice L Brinkmeyer-Langford, Jonathan H Soslow, Manisha Gupte, Douglas B Sawyer, Joe N Kornegay, Cristi L Galindo (2017). GRMD cardiac and skeletal muscle metabolism gene profiles are distinct. BMC MEDICAL GENOMICS. 1, 21
  • Candice Brinkmeyer-Langford, Cynthia Balog-Alvarez, James J Cai, Brian W Davis, Joe N Kornegay (2016). Genome-wide association study to identify potential genetic modifiers in a canine model for Duchenne muscular dystrophy. BMC GENOMICS., 665
  • Candice L Brinkmeyer-Langford, Jinting Guan, Guoli Ji, James J Cai (2016). Aging Shapes the Population-Mean and -Dispersion of Gene Expression in Human Brains. FRONTIERS IN AGING NEUROSCIENCE., 183
  • Joe N Kornegay, Daniel J Bogan, Janet R Bogan, Jennifer L Dow, Jiahui Wang, Zheng Fan, Naili Liu, Leigh C Warsing, Robert W Grange, Mihye Ahn, Cynthia J Balog-Alvarez, Steven W Cotten, Monte S Willis, Candice Brinkmeyer-Langford, Hongtu Zhu, Joe Palandra, Carl A Morris, Martin A Styner, Kathryn R Wagner (2016). Dystrophin-deficient dogs with reduced myostatin have unequal muscle growth and greater joint contractures. SKELETAL MUSCLE., 14
  • Cristi L Galindo, Jonathan H Soslow, Candice L Brinkmeyer-Langford, Manisha Gupte, Holly M Smith, Seng Sengsayadeth, Douglas B Sawyer, D Woodrow Benson, Joe N Kornegay, Larry W Markham (2016). Translating golden retriever muscular dystrophy microarray findings to novel biomarkers for cardiac/skeletal muscle function in Duchenne muscular dystrophy. PEDIATRIC RESEARCH. 4, 629-36

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