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Ramesh Vemulapalli

Department Head

Email: RVemulapalli@cvm.tamu.edu

Phone: (979) 862-6559

Office: VIDI 370 D

Mailstop: 4467

Department: VTPB

Photo of Vemulapalli, Ramesh

Education

  • Ph.D. Microbiology & Immunology, University of Maryland, College Park 1996
  • M.V.Sc. Animal Biochemistry, Indian Veterinary Research Institute 1989
  • B.V.Sc. &A.H. Veterinary Sciences, Andhra Pradesh Agricultural University 1986

Scholarly Interests

Dr. Vemulapalli’s research is primarily focused on the development of recombinant vaccines for infectious diseases. One of the targets of his vaccine research is brucellosis, a bacterial zoonotic disease caused by certain members of the genus Brucella. Brucellosis is a great concern to public health in developing countries due to widespread prevalence of Brucella infections in livestock. In the US, reservoirs of Brucella infections in wildlife, such as bison, elk, and feral swine, continue to pose a threat to livestock industries and human health. The currently available brucellosis veterinary vaccines are neither efficacious in wild animals nor safe for human use. Dr. Vemulapalli has developed novel recombinant vaccine strains that showed dramatically enhanced vaccine efficacy against brucellosis in murine models. Other ongoing research projects in his laboratory are aimed at understanding the pathogenic mechanisms of Brucella species, developing attenuated Brucella strains as vectors to deliver protective proteins of other pathogens, and development of molecular diagnostics assays for disease investigations.

Publications

Overexpression of Brucella putative glycosyltransferase WbkA in B. abortus RB51 leads to production of exopolysaccharide.
Neha Dabral, Neeta Jain-Gupta, Mohamed N Seleem, Nammalwar Sriranganathan, Ramesh Vemulapalli
Frontiers in cellular and infection microbiology. 2015 5:54.
Evaluation of three 5' exonuclease-based real-time polymerase chain reaction assays for detection of pathogenic Leptospira species in canine urine.
Jamie M Fink, George E Moore, Ruth Landau, Ramesh Vemulapalli
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. 2015 27(2):159-66.
Immunotherapeutics to prevent the replication of Brucella in a treatment failure mouse model.
N Jain-Gupta, A Contreras-Rodriguez, G P Smith, V K Garg, S G Witonsky, S Isloor, R Vemulapalli, S M Boyle, N Sriranganathan
Vaccine. 2014 32(8):918-23.
Characterization of recombinant B. abortus strain RB51SOD toward understanding the uncorrelated innate and adaptive immune responses induced by RB51SOD compared to its parent vaccine strain RB51.
Jianguo Zhu, Charles B Larson, Megan Ann Ramaker, Kimberly Quandt, Jered M Wendte, Kimberly P Ku, Fang Chen, George W Jourdian, Ramesh Vemulapalli, Gerhardt G Schurig, Yongqun He
Frontiers in cellular and infection microbiology. 2012 1:10.
Prevalence and molecular detection of Anaplasma marginale, Babesia bovis and Babesia bigemina in cattle from Puntarenas Province, Costa Rica.
Emily Shebish, Ramesh Vemulapalli, Christian Oseto
Veterinary parasitology. 2012 188(1-2):164-7.
Identification of a Mycoplasma ovis-like organism in a herd of farmed white-tailed deer (Odocoileus virginianus) in rural Indiana.
Katie M Boes, Kristina O Goncarovs, Craig A Thompson, Lindsay A Halik, Andrea P Santos, Ana M S Guimaraes, Marybeth Miskovic Feutz, Patricia J Holman, Ramesh Vemulapalli, Joanne B Messick
Veterinary clinical pathology. 2012 41(1):77-83.
Cerebral phaeohyphomycosis due to Cladophialophora bantiana in a Huacaya alpaca (Vicugna pacos).
C Frank, R Vemulapalli, T Lin
Journal of comparative pathology. 2011 145(4):410-3.
Recombinant antigen-based enzyme-linked immunosorbent assay for diagnosis of Baylisascaris procyonis larva migrans.
Sriveny Dangoudoubiyam, Ramesh Vemulapalli, Momar Ndao, Kevin R Kazacos
Clinical and vaccine immunology : CVI. 2011 18(10):1650-5.
A quantitative TaqMan PCR assay for the detection of Mycoplasma suis.
A M S Guimaraes, R F C Vieira, R Poletto, R Vemulapalli, A P Santos, W de Moraes, Z S Cubas, L C Santos, J N Marchant-Forde, J Timenetsky, A W Biondo, J B Messick
Journal of applied microbiology. 2011 111(2):417-25.
Immunization of mice with gamma-irradiated Brucella neotomae and its recombinant strains induces protection against virulent B. abortus, B. melitensis, and B. suis challenge.
Dina Moustafa, Virendra K Garg, Neeta Jain, Nammalwar Sriranganathan, Ramesh Vemulapalli
Vaccine. 2011 29(4):784-94.
Identification of a single-nucleotide insertion in the promoter region affecting the sodC promoter activity in Brucella neotomae.
Dina A Moustafa, Neeta Jain, Nammalwar Sriranganathan, Ramesh Vemulapalli
PloS one. 2010 5(11):.
Molecular cloning of an immunogenic protein of Baylisascaris procyonis and expression in Escherichia coli for use in developing improved serodiagnostic assays.
Sriveny Dangoudoubiyam, Ramesh Vemulapalli, Kathy Hancock, Kevin R Kazacos
Clinical and vaccine immunology : CVI. 2010 17(12):1933-9.
Systemic sarcocystosis in a striped skunk (Mephitis mephitis).
G N Burcham, J A Ramos-Vara, R Vemulapalli
Veterinary pathology. 2010 47(3):560-4.
Evaluation of cross-reactive cell-mediated immune responses among human, bovine and porcine adenoviruses.
A Sharma, M Tandon, Y S Ahi, D S Bangari, R Vemulapalli, S K Mittal
Gene therapy. 2010 17(5):634-42.
Coccidioides posadasii keratouveitis in a llama (Lama glama).
Martin E Coster, José A Ramos-Vara, Ramesh Vemulapalli, Jean Stiles, Sheryl G Krohne
Veterinary ophthalmology. 2010 13(1):53-7.
PCR assays for detection of Baylisascaris procyonis eggs and larvae.
Sriveny Dangoudoubiyam, Ramesh Vemulapalli, Kevin R Kazacos
The Journal of parasitology. 2009 95(3):571-7.
Pathology in practice. Inflammatory changes in the cerebrum, cerebellum, and brainstem in a dog.
Pamela J Mouser, José A Ramos-Vara, Ramesh Vemulapalli, J Catharine Scott-Moncrieff
Journal of the American Veterinary Medical Association. 2009 235(10):1153-5.
A real-time TaqMan RT-PCR assay with an internal amplification control for rapid detection of transmissible gastroenteritis virus in swine fecal samples.
Ramesh Vemulapalli, Jatinder Gulani, Cecilia Santrich
Journal of virological methods. 2009 162(1-2):231-5.
Intraocular sarcomas in two rabbits.
Leslie McPherson, Shelley J Newman, Nancy McLean, Stephanie McCain, Ramesh Vemulapalli, Stephen Kania, Richard R Dubielzig
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. 2009 21(4):547-51.
Identification of Bartonella henselae in an aborted equine fetus.
R Johnson, J Ramos-Vara, R Vemulapalli
Veterinary pathology. 2009 46(2):277-81.
Activity of native vs. synthetic promoters in Brucella.
Mohamed N Seleem, Neeta Jain, Hamzeh Alqublan, Ramesh Vemulapalli, Stephen M Boyle, Nammalwar Sriranganathan
FEMS microbiology letters. 2008 288(2):211-5.
Encephalitozoon cuniculi-associated placentitis and perinatal death in an alpaca (Lama pacos).
J D Webster, M A Miller, R Vemulapalli
Veterinary pathology. 2008 45(2):255-8.
Toxoplasmosis in a woodchuck (Marmota monax) and two American red squirrels (Tamiasciurus hudsonicus).
Dinesh S Bangari, Pamela Mouser, Margaret A Miller, Gregory W Stevenson, Ramesh Vemulapalli, H Leon Thacker
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. 2007 19(6):705-9.
Prevention of vertical transmission of Neospora caninum in C57BL/6 mice vaccinated with Brucella abortus strain RB51 expressing N. caninum protective antigens.
Sheela Ramamoorthy, Neelima Sanakkayala, Ramesh Vemulapalli, Neeta Jain, David S Lindsay, Gerhardt S Schurig, Stephen M Boyle, Nammalwar Sriranganathan
International journal for parasitology. 2007 37(13):1531-8.
Prevention of lethal experimental infection of C57BL/6 mice by vaccination with Brucella abortus strain RB51 expressing Neospora caninum antigens.
Sheela Ramamoorthy, Neelima Sanakkayala, Ramesh Vemulapalli, Robert B Duncan, David S Lindsay, Gerhart S Schurig, Stephen M Boyle, Ramanathan Kasimanickam, Nammalwar Sriranganathan
International journal for parasitology. 2007 37(13):1521-9.
Reduced cerebral infection of Neospora caninum in BALB/c mice vaccinated with recombinant Brucella abortus RB51 strains expressing N. caninum SRS2 and GRA7 proteins.
Ramesh Vemulapalli, Neelima Sanakkayala, Jatinder Gulani, Gerhardt G Schurig, Stephen M Boyle, David S Lindsay, Nammalwar Sriranganathan
Veterinary parasitology. 2007 148(3-4):219-30.
Novel swine influenza virus subtype H3N1, United States.
Porntippa Lekcharoensuk, Kelly M Lager, Ramesh Vemulapalli, Mary Woodruff, Amy L Vincent, Jürgen A Richt
Emerging infectious diseases. 2006 12(5):787-94.
Vaccination with gamma-irradiated Neospora caninum tachyzoites protects mice against acute challenge with N. caninum.
S Ramamoorthy, D S Lindsay, G G Schurig, S M Boyle, R B Duncan, R Vemulapalli, N Sriranganathan
The Journal of eukaryotic microbiology. 2006 53(2):151-6.
Evaluation of Brucella abortus DNA vaccine by expression of Cu-Zn superoxide dismutase antigen fused to IL-2.
Andrés González-Smith, Ramesh Vemulapalli, Edilia Andrews, Angel Oñate
Immunobiology. 2006 211(1-2):65-74.
Role in virulence of a Brucella abortus protein exhibiting lectin-like activity.
Tracy H Vemulapalli, Ramesh Vemulapalli, Gerhardt G Schurig, Stephen M Boyle, Nammalwar Sriranganathan
Infection and immunity. 2005 74(1):183-91.
Immune responses of mice to vaccinia virus recombinants expressing either Listeria monocytogenes partial listeriolysin or Brucella abortus ribosomal L7/L12 protein.
Simge Baloglu, Stephen M Boyle, Ramesh Vemulapalli, Nammalwar Sriranganathan, Gerhardt G Schurig, Thomas E Toth
Veterinary microbiology. 2005 109(1-2):11-7.
Molecular detection of Leptospira kirschneri in tissues of a prematurely born foal.
Ramesh Vemulapalli, Ingeborg M Langohr, Alfredo Sanchez, Matti Kiupel, Carol A Bolin, Ching-Ching Wu, Tsang-Long Lin
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. 2005 17(1):67-71.
Improved expression vector for Brucella species.
Mohamed N Seleem, Ramesh Vemulapalli, Stephen M Boyle, Gerhardt G Schurig, Nammalwar Sriranganathan
BioTechniques. 2004 37(5):740.
Enhanced efficacy of recombinant Brucella abortus RB51 vaccines against B. melitensis infection in mice.
Ramesh Vemulapalli, Andrea Contreras, Neelima Sanakkayala, Nammalwar Sriranganathan, Stephen M Boyle, Gerhardt G Schurig
Veterinary microbiology. 2004 102(3-4):237-45.
A recombinant vaccine expressing a mammalian Mycobacterium sp. antigen is immunostimulatory but not protective in striped bass.
David J Pasnik, Ramesh Vemulapalli, Stephen A Smith, Gerhardt G Schurig
Veterinary immunology and immunopathology. 2003 95(1-2):43-52.
Brucella abortus RB51: enhancing vaccine efficacy and developing multivalent vaccines.
Ramesh Vemulapalli, Yongqun He, Nammalwar Sriranganathan, Stephen M Boyle, Gerhardt G Schurig
Veterinary microbiology. 2002 90(1-4):521-32.
Induction of specific cytotoxic lymphocytes in mice vaccinated with Brucella abortus RB51.
Y He, R Vemulapalli, A Zeytun, G G Schurig
Infection and immunity. 2001 69(9):5502-8.
Deletion of wboA enhances activation of the lectin pathway of complement in Brucella abortus and Brucella melitensis.
C M Fernandez-Prada, M Nikolich, R Vemulapalli, N Sriranganathan, S M Boyle, G G Schurig, T L Hadfield, D L Hoover
Infection and immunity. 2001 69(7):4407-16.
Molecular comparison of the dense granule proteins GRA6 and GRA7 of Neospora hughesi and Neospora caninum.
C P Walsh, R Vemulapalli, N Sriranganathan, A M Zajac, M C Jenkins, D S Lindsay
International journal for parasitology. 2001 31(3):253-8.
Complementation of Brucella abortus RB51 with a functional wboA gene results in O-antigen synthesis and enhanced vaccine efficacy but no change in rough phenotype and attenuation.
R Vemulapalli, Y He, L S Buccolo, S M Boyle, N Sriranganathan, G G Schurig
Infection and immunity. 2000 68(7):3927-32.
Brucella abortus strain RB51 as a vector for heterologous protein expression and induction of specific Th1 type immune responses.
R Vemulapalli, Y He, S M Boyle, N Sriranganathan, G G Schurig
Infection and immunity. 2000 68(6):3290-6.
Overexpression of protective antigen as a novel approach to enhance vaccine efficacy of Brucella abortus strain RB51.
R Vemulapalli, Y He, S Cravero, N Sriranganathan, S M Boyle, G G Schurig
Infection and immunity. 2000 68(6):3286-9.
Characterization of specific immune responses of mice inoculated with recombinant vaccinia virus expressing an 18-kilodalton outer membrane protein of Brucella abortus.
R Vemulapalli, S Cravero, C L Calvert, T E Toth, N Sriranganathan, S M Boyle, O L Rossetti, G G Schurig
Clinical and diagnostic laboratory immunology. 2000 7(1):114-8.
Identification of an IS711 element interrupting the wboA gene of Brucella abortus vaccine strain RB51 and a PCR assay to distinguish strain RB51 from other Brucella species and strains.
R Vemulapalli, J R McQuiston, G G Schurig, N Sriranganathan, S M Halling, S M Boyle
Clinical and diagnostic laboratory immunology. 1999 6(5):760-4.
Genetic characterization of a Tn5-disrupted glycosyltransferase gene homolog in Brucella abortus and its effect on lipopolysaccharide composition and virulence.
J R McQuiston, R Vemulapalli, T J Inzana, G G Schurig, N Sriranganathan, D Fritzinger, T L Hadfield, R A Warren, L E Lindler, N Snellings, D Hoover, S M Halling, S M Boyle
Infection and immunity. 1999 67(8):3830-5.
Vaccination with live Escherichia coli expressing Brucella abortus Cu/Zn superoxide dismutase protects mice against virulent B. abortus.
A A Oñate, R Vemulapalli, E Andrews, G G Schurig, S Boyle, H Folch
Infection and immunity. 1999 67(2):986-8.
Cloning and sequencing of yajC and secD homologs of Brucella abortus and demonstration of immune responses to YajC in mice vaccinated with B. abortus RB51.
R Vemulapalli, A J Duncan, S M Boyle, N Sriranganathan, T E Toth, G G Schurig
Infection and immunity. 1998 66(12):5684-91.
Molecular basis for antigenic variation of a protective strain-specific antigen of Ehrlichia risticii.
B Biswas, R Vemulapalli, S K Dutta
Infection and immunity. 1998 66(8):3682-8.
Cloning and molecular analysis of genes encoding two immunodominant antigens of Ehrlichia risticii.
R Vemulapalli, B Biswas, S K Dutta
Microbial pathogenesis. 1998 24(6):361-72.
Studies with recombinant proteins of Ehrlichia risticii: identification of strain-specific antigen as a protective antigen.
R Vemulapalli, B Biswas, S K Dutta
Veterinary parasitology. 1998 76(3):189-202.
Pathogenic, immunologic, and molecular differences between two Ehrlichia risticii strains.
R Vemulapalli, B Biswas, S K Dutta
Journal of clinical microbiology. 1996 33(11):2987-93.
Detection of Ehrlichia risticii from feces of infected horses by immunomagnetic separation and PCR.
B Biswas, R Vemulapalli, S K Dutta
Journal of clinical microbiology. 1995 32(9):2147-51.


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