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Thomas Ficht



Phone: (979) 845-4118

Mailstop: 4467

Department: VTPB

Photo of Ficht, Thomas


  • Ph.D. Biochemistry, Columbia University 1980
  • M.Phil. Biochemistry, Columbia University 1976
  • M.S. Chemistry, Polytechnic Institute of Brooklyn 1973
  • B.S. Chemistry and Biochemistry, Polytechnic Institute of Brooklyn 1972


  • AOAC-SPARDA Brucella Working Group

Scholarly Interests

Mechanisms of invasion and survival of intracellular bacteria within host cells; study of bacterial and host gene expression during infection and its use in the development and application of biosignatures; development of improved vaccines using genetic approaches to attenuate survival and identify therapeutic targets; development of subunit vaccines. Characterization of bacterial population structures through genomic analysis.


Pathogenesis and immunobiology of brucellosis: review of Brucella-host interactions
de Figueiredo P, Ficht TA, Rice-Ficht A, Rossetti CA, Adams LG
Am J Pathology. 2015
Brucella dissociation is essential for macrophage egress and bacterial dissemination
Pei J, Kahl-McDonagh M, Ficht TA
Front Cell Infect Microbiol. 2014
Aerosol-induced brucellosis increases tlr-2 expression and increased complexity in the microanatomy of astroglia in rhesus macaques
Lee, K.M., K.B. Chiu, H.A. Sansing, P.J. Didier, T.A. Ficht, A.M. Arenas-Gamboa, C.J. Roy, A.G. Maclean
Front Cell Infect Microbiol. 2013
Host-Brucella interactions and the Brucella genome as tools for subunit antigen discovery and immunization against brucellosis
Gomez G, Adams LG, Rice-Ficht A, Ficht TA
Frontiers Cell Infect Microbiol. 2013
Diverse genetic regulon of the virulence-associated transcriptional regulator MucR in Brucella abortus 2308
Caswell CC, Elhassanny AE, Planchin EE, Roux CM, Weeks-Gorospe JN, Ficht TA, et al
Infection and Immunity. 2013
Immunogenic and invasive properties of Brucella melitensis 16M outer membrane protein vaccine candidates identified via a reverse vaccinology approach
Gomez G, Pei J, Mwangi W, Adams LG, Rice-Ficht A, Ficht TA
Plos One. 2013
Serologic response in bottlenose dolphins Tursiops truncatus infected with Brucella sp. using a dolphin-specific indirect ELISA
Meegan J, Dunn JL, Venn-Watson SK, Smith CR, Sidor I, Jensen ED, et al
Dis Aquat Org. 2012
Toll-like receptors are critical for clearance of Brucella and play different roles in development of adaptive immunity following aerosol challenge in mice
Pei J, Ding X, Fan Y, Rice-Ficht A, Ficht TA
Front Cell Infect Biol. 2012
Extended safety and efficacy studies of the attenuated Brucella vaccine candidates 16M∆vjbR and S19∆vjbR in the immunocompromised IRF-1-/- mouse model
Arenas-Gamboa, A.M., A.C. Rice-Ficht, Y. Fan, M.M. Kahl-McDonagh, and T.A. Ficht
Infection and Immunity. 2012
Functional analysis of host factors that mediate the intracellular lifestyle of Cryptococcus neoformans.
Qin, Q.-M., J. Luo, X. Lin, J. Pei, L. Li, T. A. Ficht, and P. de Figueiredo
PLoS Pathog. 2011
Lipopolysaccharide-deficient Brucella variants arise spontaneously during infection
Turse, J. E., J. Pei
Front Microbiol. 2011

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