Sakhila Banu

Toxicology

Reproductive Biology

Environmental Health

My Bibliography on Google Scholar: https://scholar.google.com/citations?user=EpN78RQAAAAJ&hl=en

‪Sakhila Banu - ‪Google Scholar

My Bibliography on National Library of Medicine (ncbi):

https://www.ncbi.nlm.nih.gov/myncbi/sakhila.banu.1/bibliography/public/

Journal Articles

2022

01. Sivakumar KK, Stanley J, Wuri L, Dutta S, Wu JZ, Arosh JA and Banu SK. Inhibition of Sirtuin-1 hyperacetylates p53 and abrogates SIRT1-p53 interaction in Cr(VI)-Induced Apoptosis in the ovary. Reproductive Toxicology 2022 (https://doi.org/10.1016/j.reprotox.2022.03.007).

02. Wuri L, Arosh JA, *Wu JZ, Banu SK. Exposure to hexavalent chromium causes infertility by disrupting cytoskeletal machinery and mitochondrial function of the metaphase II oocytes in superovulated rats. Toxicology Reports 2022; 9: 219-229.

03. Arosh JA, Sivakumar KK, Lee J and Banu SK. Effects of Selective Inhibition of Prostaglandin E2 Receptors EP2 and EP4 on the miRNA Profile in Endometriosis (Ms. Ref. No.MCE-D-22-00178), Molecular and Cellular Endocrinology, 2022 https://doi.org/10.1016/j.mce.2022.111728 (available online).

04. Dutta S, *Banu SK and Arosh JA. Endocrine disruptors and endometriosis (Ms. Ref No. RTX-D-22-00093), Reproductive Toxicology, 2022 (In revision). *Co-corresponding author. 

05. Arosh JA, Lee J, Banu SK. Effects of dual inhibition of AKT and ERK1/2 pathways on endometrial pro- inflammatory, hormonal, and epigenetic microenvironment in endometriosis. Mol Cell Endocrinol. 2022 Aug 31;111446. Mol Cell Endocrinol. 2022; 539:111446.

2021

06. Navin AK, Aruldhas MM, Shobana N, Mani KK, Srinivasan N, Michael FM, Banu SK. Prenatal exposure to hexavalent chromium disrupts testicular steroidogenic pathway in F1 male rats. Reproductive Toxicology. 2021; 101 (page 63-73).

2019

07. Stanley JA, Arosh JA, Hoyer PB, Banu SK. (2019) Ex Vivo Fetal Whole Ovarian Culture Model: An Essential Tool for Studies in Reproductive Toxicology and Pharmacology. In: Hansen J., Winn L. (eds) Developmental Toxicology. Methods in Molecular Biology, vol. 1965:107-12 doi: 10.1007/978-1-4939-9182-2_8.Humana, New York, NY. This article has 1100 downloads in May 2022.

08. Banu SK, Arosh JA*. Dual inhibition of ERK1/2 and AKT pathways is required to suppress the growth and survival of endometriotic cells and lesions, Molecular & Cellular Endocrinology, Mol Cell Endocrinol. Dec 2019. pii: S0303-7207(18)30364-2. doi: 10.1016/j.mce.20112.011.

09. Arosh JA, Banu SK. Molecular, Cellular, and Epigenetic Signatures of Prostaglandin E2 in Endometriosis. Current Women's health Reviews 2018. 14:127-146.

2018

10. Banu SK. Chromium Burden in Human Placenta: Author(s) Responses to Thompson et al. SK Banu - Toxicological Sciences, 2018

11. Sales MS, Roy A, Antony L, Banu SK, Jeyaraman S Manikkam R. Octyl gallate and gallic acid isolated from Terminalia bellarica regulates normal cell cycle in human breast cancer cell lines. Biomedicine & Pharmacotherapy 2018. 103: 1577-1584.

12. Banu SK, Stanley JA, Taylor RJ, Sivakumar KK, Arosh JA, Lixia Zeng, Pennathur S, Padmanabhan V. Sexually Dimorphic Impact of Chromium Accumulation on Human Placental Oxidative Stress and Apoptosis. Toxicol Sci. 2018 Feb 1;161(2):375-387.

2017

13. Kumar KM, Aruldhas MM, Banu SL, Sadasivam B, Vengatesh G, Ganesh KM, Navaneethabalakrishnan S, Navin AK, Michael FM, Venkatachalam S, Stanley JA, Ramachandran I, Banu SK, Akbarsha MA. Male reproductive toxicity of CrVI: In-utero exposure to CrVI at the critical window of testis differentiation represses the expression of Sertoli cell tight junction proteins and hormone receptors in adult F1 progeny rats. Reprod Toxicol. 2017 Feb 10;69:84-98.

14. Editor's Highlight: Banu SK*, Stanley JA, Sivakumar KK, Taylor JA, Arosh JA, Burghardt RC. 2016. Exposure to CrVI during early pregnancy increases oxidative stress and disrupts the expression of antioxidant proteins in placental compartments. Toxicological Sciences, 2017 Toxicol Sci. 2017 Feb;155(2):497-511.

2016

15. Banu SK*, Stanley JA, Sivakumar KK, Arosh JA, Taylor JA, Burghardt RC. 2016. Chromium VI-induced developmental toxicity of placenta is mediated through spatiotemporal dysregulation of cell survival and apoptotic proteins in rats. Reproductive Toxicology, 2016 pii: S0890-6238(16)30263-5.

16. Arosh JA, Banu SK, McCracken JA. Novel concepts on the role of prostaglandins on luteal maintenance and maternal recognition and establishment of pregnancy in ruminants. J Dairy Sci. 2016 Jul;99(7):5926-40.

17. Banu SK*, Stanley JA, Sivakumar KK, Arosh JA, Burghardt RC. Resveratrol protects the ovary against chromium-toxicity by enhancing endogenous antioxidant enzymes and inhibiting metabolic clearance of estradiol. Toxicology and Applied Pharmacology, 2016, 303:65-78.

2015

18. Stanley JA, Neelamohan R, Suthagar E, Vengatesh G, Jayakumar J, Chandrasekaran M, Banu SK, Aruldhas MM. Lipid peroxidation and antioxidants status in human malignant and non-malignant thyroid tumours. Hum Exp Toxicol 2015; 1-13.

19. Stanley JA, Arosh JA, Burghardt RC, Banu SK*. A fetal whole ovarian culture model for the evaluation of CrVI-induced developmental toxicity during germ cell nest breakdown. Toxicology and applied pharmacology 2015; 289:58-69 Grant support, NIH (BANU, PI). JOURNAL COVER IMAGE.

20. Lee J, Banu SK, McCracken JA, Arosh JA. Early pregnancy modulates survival and apoptosis pathways in the corpus luteum in sheep. Reproduction 2015;In Press

21. Banu SK*, Stanley JA, Sivakumar KK, Arosh JA, Barhoumi R, Burghardt RC. Identifying a novel role for X-prolyl aminopeptidase (Xpnpep) 2 in CrVI-induced adverse effects on germ cell nest breakdown and follicle development in rats. Biology of reproduction 2015; 92:67 Grant support, NIH (BANU, PI)

22. Arosh JA, Lee J, Starzinski-Powitz A, Banu SK. Selective inhibition of prostaglandin E2 receptors EP2 and EP4 modulates DNA methylation and histone modification machinery proteins in human endometriotic cells. Molecular and cellular endocrinology 2015; 409:51-58

23. Arosh JA*, Lee J, Balasubbramanian D, Stanley JA, Long CR, Meagher MW, Osteen KG, Bruner-Tran KL, Burghardt RC, Starzinski-Powitz A, Banu SK*. Molecular and preclinical basis to inhibit PGE2 receptors EP2 and EP4 as a novel nonsteroidal therapy for endometriosis. Proc Natl Acad Sci U S A 2015; 112:9716-9721

24. Annapoorna K AM, Chandrasekaran M, Stanley JA, Neelamohan R, Suthagar E, Banu S, Srinivasan N, Banu SK. Can the expression pattern of estrogen receptor alpha and beta proteins in papillary thyroid carcinoma be of prognostic value? Journal of International Medical Sciences Academy 2015; 28:79-82

2014

25. Stanley JA, Sivakumar KK, Arosh JA, Burghardt RC, Banu SK*. Edaravone mitigates hexavalent chromium-induced oxidative stress and depletion of antioxidant enzymes while estrogen restores antioxidant enzymes in the rat ovary in F1 offspring. Biology of reproduction 2014; 91:12 Grant support, NIH (BANU, PI)

26. Sivakumar KK, Stanley JA, Arosh JA, Pepling ME, Burghardt RC, Banu SK*. Prenatal exposure to chromium induces early reproductive senescence by increasing germ cell apoptosis and advancing germ cell cyst breakdown in the F1 offspring. Dev Biol 2014; 388:22-34 Grant support, NIH (BANU, PI)

27. Pitchai D, Roy A, Banu SK. In Vitro and In Silico Evaluation of NF-κB Targeted Costunolide Action on Estrogen Receptor-Negative Breast Cancer Cells - A Comparison with Normal Breast Cells. Phytotherapy Research 2014; 28:1499-1505

28. Lee J, Stanley JA, McCracken JA, Banu SK, Arosh JA. Intrauterine coadministration of ERK1/2 inhibitor U0126 inhibits interferon TAU action in the endometrium and restores luteolytic PGF2alpha pulses in sheep. Biology of reproduction 2014; 91:46

2013

29. Stanley JA, Sivakumar KK, Nithy TK, Arosh JA, Hoyer PB, Burghardt RC, Banu SK*. Postnatal exposure to chromium through mother's milk accelerates follicular atresia in F1 offspring through increased oxidative stress and depletion of antioxidant enzymes. Free radical biology & medicine 2013; 61:179-196 Grant support, NIH (BANU, PI)

30. Lee J, McCracken JA, Banu SK, Arosh JA. Intrauterine inhibition of prostaglandin transporter protein blocks release of luteolytic PGF2alpha pulses without suppressing endometrial expression of estradiol or oxytocin receptor in ruminants. Biology of reproduction 2013; 89:27

31. Lee J, Banu SK, Burghardt RC, Starzinski-Powitz A, Arosh JA. Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits adhesion of human endometriotic epithelial and stromal cells through suppression of integrin-mediated mechanisms. Biology of reproduction 2013; 88:77

32. Lebovic DI, Kavoussi SK, Lee J, Banu SK, Arosh JA. PPARgamma activation inhibits growth and survival of human endometriotic cells by suppressing estrogen biosynthesis and PGE2 signaling. Endocrinology 2013; 154:4803-4813

2012

33. Stanley JA, Aruldhas MM, Chandrasekaran M, Neelamohan R, Suthagar E, Annapoorna K, Sharmila S, Jayakumar J, Jayaraman G, Srinivasan N, Banu SK. Androgen receptor expression in human thyroid cancer tissues: a potential mechanism underlying the gender bias in the incidence of thyroid cancers. J Steroid Biochem Mol Biol 2012; 130:105-124

34. Lee J, McCracken JA, Stanley JA, Nithy TK, Banu SK, Arosh JA. Intraluteal prostaglandin biosynthesis and signaling are selectively directed towards PGF2alpha during luteolysis but towards PGE2 during the establishment of pregnancy in sheep. Biology of reproduction 2012; 87:97

35. Lee J, Banu SK, Nithy TK, Stanley JA, Arosh JA. Early pregnancy induced expression of prostaglandin E2 receptors EP2 and EP4 in the ovine endometrium and regulated by interferon tau through multiple cell signaling pathways. Molecular and cellular endocrinology 2012; 348:211-223

2011

36. Stanley JA, Lee J, Nithy TK, Arosh JA, Burghardt RC, Banu SK*. Chromium-VI arrests cell cycle and decreases granulosa cell proliferation by down-regulating cyclin-dependent kinases (CDK) and cyclins and up-regulating CDK-inhibitors. Reproductive toxicology (Elmsford, NY) 2011; 32:112-123 Grant support, NIH (BANU, PI)

37. Samuel JB, Stanley JA, Roopha DP, Vengatesh G, Anbalagan J, Banu SK, Aruldhas MM. Lactational hexavalent chromium exposure-induced oxidative stress in rat uterus is associated with delayed puberty and impaired gonadotropin levels. Hum Exp Toxicol 2011; 30:91-101

38. Lee J, Banu SK, Subbarao T, Starzinski-Powitz A, Arosh JA. Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits invasion of human immortalized endometriotic epithelial and stromal cells through suppression of metalloproteinases. Molecular and cellular endocrinology 2011; 332:306-313

39. Banu SK*, Stanley JA, Lee J, Stephen SD, Arosh JA, Hoyer PB, Burghardt RC. Hexavalent chromium-induced apoptosis of granulosa cells involves selective sub-cellular translocation of Bcl-2 members, ERK1/2 and p53. Toxicology and applied pharmacology 2011; 251:253-266 Grant support, NIH (BANU, PI)

2010

40. Stanley JA, Aruldhas MM, Yuvaraju PB, Banu SK, Anbalagan J, Neelamohan R, Annapoorna K, Jayaraman G. Is gender difference in postnatal thyroid growth associated with specific expression patterns of androgen and estrogen receptors? Steroids 2010; 75:1058-1066

41. Lee J, McCracken JA, Banu SK, Rodriguez R, Nithy TK, Arosh JA. Transport of prostaglandin F(2alpha) pulses from the uterus to the ovary at the time of luteolysis in ruminants is regulated by prostaglandin transporter-mediated mechanisms. Endocrinology 2010; 151:3326-3335

42. Lee J, Banu SK, Rodriguez R, Starzinski-Powitz A, Arosh JA. Selective blockade of prostaglandin E2 receptors EP2 and EP4 signaling inhibits proliferation of human endometriotic epithelial cells and stromal cells through distinct cell cycle arrest. Fertility and sterility 2010; 93:2498-2506

43. Banu SK, Lee J, Stephen SD, Nithy TK, Arosh JA. Interferon tau regulates PGF2alpha release from the ovine endometrial epithelial cells via activation of novel JAK/EGFR/ERK/EGR-1 pathways. Mol Endocrinol 2010; 24:2315-2330

2009

44. Banu SK, Starzinski-Powitz A, Speights VO, Burghardt RC, Arosh JA. Induction of peritoneal endometriosis in nude mice with use of human immortalized endometriosis epithelial and stromal cells: a potential experimental tool to study molecular pathogenesis of endometriosis in humans. Fertility and sterility 2009; 91:2199-2209

45. Banu SK, Lee J, Speights VO, Jr., Starzinski-Powitz A, Arosh JA. Selective inhibition of prostaglandin E2 receptors EP2 and EP4 induces apoptosis of human endometriotic cells through suppression of ERK1/2, AKT, NFkappaB, and beta-catenin pathways and activation of intrinsic apoptotic mechanisms. Mol Endocrinol 2009; 23:1291-1305

2008

46. Banu SK*, Samuel JB, Arosh JA, Burghardt RC, Aruldhas MM. Lactational exposure to hexavalent chromium delays puberty by impairing ovarian development, steroidogenesis and pituitary hormone synthesis in developing Wistar rats. Toxicology and applied pharmacology 2008; 232:180-189

47. Banu SK, Lee J, Starzinski-Powitz A, Arosh JA. Gene expression profiles and functional characterization of human immortalized endometriotic epithelial and stromal cells. Fertility and sterility 2008; 90:972-987

48. Banu SK, Lee J, Speights VO, Jr., Starzinski-Powitz A, Arosh JA. Cyclooxygenase-2 regulates survival, migration, and invasion of human endometriotic cells through multiple mechanisms. Endocrinology 2008; 149:1180-1189

49. Banu SK, Lee J, Satterfield MC, Spencer TE, Bazer FW, Arosh JA. Molecular cloning and characterization of prostaglandin (PG) transporter in ovine endometrium: role for multiple cell signaling pathways in transport of PGF2alpha. Endocrinology 2008; 149:219-231

2005

50. Banu SK, Arosh JA, Chapdelaine P, Fortier MA. Expression of prostaglandin transporter in the bovine uterus and fetal membranes during pregnancy. Biology of reproduction 2005; 73:230-236

2004

51. Arosh JA¶, Banu SK¶, Kimmins S, Chapdelaine P, Maclaren LA, Fortier MA. Effect of interferon-tau on prostaglandin biosynthesis, transport, and signaling at the time of maternal recognition of pregnancy in cattle: evidence of polycrine actions of prostaglandin E2. Endocrinology 2004; 145:5280-5293 (¶ equal contribution)

52. Arosh JA¶, Banu SK¶, Chapdelaine P, Madore E, Sirois J, Fortier MA. Prostaglandin biosynthesis, transport, and signaling in corpus luteum: a basis for autoregulation of luteal function. Endocrinology 2004; 145:2551-2560 (¶ equal contribution)

53. Arosh JA¶, Banu SK¶, Chapdelaine P, Fortier MA. Temporal and tissue-specific expression of prostaglandin receptors EP2, EP3, EP4, FP, and cyclooxygenases 1 and 2 in uterus and fetal membranes during bovine pregnancy. Endocrinology 2004; 145:407-417 (¶ equal contribution)

2003

54. Banu SK, Arosh JA, Chapdelaine P, Fortier MA. Molecular cloning and spatio-temporal expression of the prostaglandin transporter: a basis for the action of prostaglandins in the bovine reproductive system. Proc Natl Acad Sci U S A 2003; 100:11747-11752

55. Arosh JA, Banu SK, Chapdelaine P, Emond V, Kim JJ, MacLaren LA, Fortier MA. Molecular cloning and characterization of bovine prostaglandin E2 receptors EP2 and EP4: expression and regulation in endometrium and myometrium during the estrous cycle and early pregnancy. Endocrinology 2003; 144:3076-3091

2002

56. Banu SK, Govindarajulu P, Aruldhas MM. Developmental profiles of TSH, sex steroids, and their receptors in the thyroid and their relevance to thyroid growth in immature rats. Steroids 2002; 67:137-144

57. Banu SK, Govindarajulu P, Aruldhas MM. Testosterone and estradiol differentially regulate TSH-induced thyrocyte proliferation in immature and adult rats. Steroids 2002; 67:573-579

58. Banu SK, Govindarajulu P, Aruldhas MM. Testosterone and estradiol up-regulate androgen and estrogen receptors in immature and adult rat thyroid glands in vivo. Steroids 2002; 67:1007-1014

59. Banu SK, Aruldhas MM. Sex steroids regulate TSH-induced thyroid growth during sexual maturation in Wistar rats. Exp Clin Endocrinol Diabetes 2002; 110:37-42

2001

60. Banu SK, Govindarajulu P, Aruldhas MM. Testosterone and estradiol modulate TSH-binding in the thyrocytes of Wistar rats: influence of age and sex. J Steroid Biochem Mol Biol 2001; 78:329-342

61. Banu SK, Arosh JA, Govindarajulu P, Aruldhas MM. Testosterone and estradiol differentially regulate thyroid growth in Wistar rats from immature to adult age. Endocr Res 2001; 27:447-463

62. Arosh JA, Banu SK, Devanathan TG, Kathiresan D. Progesterone, estradiol, luteinizing hormone and follicle stimulating hormone profiles and their relationship with embryo production and quality of embryos in crossbred cows treated with prostaglandin F2 alpha and Folltropin. Indian Journal of Animal Sciences 2001; 71:910-914

63. Arosh JA, Banu SK, Devanathan TG, Kathiresan D. The pattern of superoestrus and its influence on ovarian response, embryo recovery and quality of embryos in prostaglandin F2 alpha and syncro-mate B induced superovulated crossbred cows. Indian Journal of Animal Sciences 2001; 71:425-429

64. Arosh JA, Banu SK, Devanathan TG, Kathiresan D. The effect of SMB on follicular dynamics during superovulation in crossbred cows. Indian Journal of Animal Reproduction 2001; 22:103-108

65. Arosh JA, Banu SK, Devanathan TG, Kathiresan D. Estradiol profile and ovarian response, embryo recovery and quality of embryos in prostaglandin F2 alpha and syncro-mate B induced superovulated crossbred cows. Indian Journal of Animal Sciences 2001; 71:421-424

2000

66. Arosh JA, Banu SK, Devanathan TG, Kathiresan D. Follicle simulating hormone profile and its correlation with ovarian response, embryo recovery and quality of embryos in prostaglandin F2 alpha and syncro-mate B induced superovulated crossbred cows. Indian Journal of Animal Sciences 2000; 70:679-683

67. Arosh JA, Banu SK, Devanathan TG, Kathiresan D. Luteinizing hormone profile and its correlation with ovarian response, embryo recovery and quality of embryos in prostaglandin F2 alpha and syncro-mate B induced superovulated crossbred cows. Indian Journal of Animal Sciences 2000; 70:576-581

68. Arosh JA, Banu SK, Devanathan TG, Kathiresan D. Progesterone profile and ovarian response, embryo recovery and quality of embryos in prostaglandin F2 alpha and syncro-mate B induced superovulated crossbred cows. Indian Journal of Animal Sciences 2000; 70:254-257.

1997

69. Vanathy B, Banu SK, Aruldhas MM, Manimaran MM, Arunakaran J, Govindarajulu P. Effect of testosterone on basal and thyrotropin induced changes on thyroidal adenosine triphosphatases. Journal of Endocrinology and Reproduction 1997; 1:35-49

Invited Reviews & Book Chapters

1. Aruldhas MM, Kalpana N, Vengatesh G, Banu SK, Govindarajulu P. Genetics of Medullary thyroid carcinoma. Journal of Endocrinology and Reproduction 2001; 5:59-76
2. Banu SK, Stanley JA, Arosh JA, Aruldhas MM. Metals in Female Reproduction. In: Reference Module in Biomedical Sciences, Michael Caplan (Editor), ISBN 9780128012383, Elsevier, USA. DOI: 10.1016/B978-0-12-801238-3.64411-2, 2018.
3. Banu SK. Heavy Metals and the Ovary. In: Hoyer PB, ed. Ovarian Toxicology, Second Edition: CRC Press; 2013:191-228.
4. Stanley JA, Neelamohan R, Suthagar E, Annapoorna K, Sharmila S, Jayakumar J, Srinivasan N, Banu SK, Chandrasekaran M, Aruldhas MM. Androgen receptor expression in human thyroid cancer tissues: a potential mechanism underlying the gender bias in the incidence of thyroid cancers. In: Perumana S, ed. Perspectives in Cancer Prevention-Translational Cancer Research. India: Springer; 2014:121-132.