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Terje Raudsepp

Terje Raudsepp

Professor & Director, Molecular Cytogenetics Lab Department of Veterinary Integrative Biosciences
Contact
Molecular Cytogenetics Laboratory
TRaudsepp@cvm.tamu.edu
9798622879
TAMU Mailstop: 4458

Research and Scholarly Interests

Comparative genomics and molecular cytogenetics of animals, birds and other vertebrates organization, function and evolution of sex chromosomes; equine genomics - genomics of genetic diseases and disorders of sexual development and reproduction; alpaca and camelid genomics.

EDUCATION

  • M.S., Tartu University, Tartu, Estonia, 1982
  • Ph.D., Swedish University of Agricultural Sciences, 1999
  • Genomics
  • Das PJ, Lyle SK, Beehan D, Chowdhary BP, Raudsepp T (2012). Cytogenetic and molecular characterization of Y isochromosome in a 63XO/64Xi(Yq) mosaic karyotype of an intersex horse. SEX DEV. 1-3, 117-27
  • Raudsepp T, Das PJ, Avila F, Chowdhary BP (2012). The pseudoautosomal region and sex chromosome aneuploidies in domestic species. SEX DEV. 1-3, 72-83
  • Raudsepp T, Durkin K, Lear TL, Das PJ, Avila F, Kachroo P, Chowdhary BP (2010). Molecular heterogeneity of XY sex reversal in horses. ANIM GENET. Suppl 2, 41-52
  • Das PJ, Chowdhary BP, Raudsepp T (2009). Characterization of the bovine pseudoautosomal region and comparison with sheep, goat, and other mammalian pseudoautosomal regions. CYTOGENET GENOME RES. 1-2, 139-47
  • Brinkmeyer-Langford CL, Childers CP, Fritz KL, Gustafson-Seabury AL, Cothran M, Raudsepp T, Womack JE, Skow LC (2009). A high resolution RH map of the bovine major histocompatibility complex. BMC GENOMICS. 10, 182
  • Liu J, Westhusin M, Johnson G, Raudsepp T, Chowdhary B, Burghardt R, Long C, Kraemer D (2009). Evaluation of culture systems for attachment and proliferation of epithelial cells cultured from ovine semen. ANIM REPROD SCI. 1-4, 49-57
  • Davis BW, Raudsepp T, Pearks Wilkerson AJ, Agarwala R, Schäffer AA, Houck M, Chowdhary BP, Murphy WJ (2009). A high-resolution cat radiation hybrid and integrated FISH mapping resource for phylogenomic studies across Felidae. GENOMICS. 4, 299-304
  • Raudsepp T, Gustafson-Seabury A, Durkin K, Wagner ML, Goh G, Seabury CM, Brinkmeyer-Langford C, Lee EJ, Agarwala R, Stallknecht-Rice E, Schäffer AA, Skow LC, Tozaki T, Yasue H, Penedo MC, Lyons LA, Khazanehdari KA, Binns MM, MacLeod JN, Distl O, Guérin G, Leeb T, Mickelson JR, Chowdhary BP (2008). A 4,103 marker integrated physical and comparative map of the horse genome. CYTOGENET GENOME RES. 1, 28-36
  • Pearks Wilkerson AJ, Raudsepp T, Graves T, Albracht D, Warren W, Chowdhary BP, Skow LC, Murphy WJ (2008). Gene discovery and comparative analysis of X-degenerate genes from the domestic cat Y chromosome. GENOMICS. 5, 329-38
  • Raudsepp T, Chowdhary BP (2008). The horse pseudoautosomal region (PAR): characterization and comparison with the human, chimp and mouse PARs. CYTOGENET GENOME RES. 2, 102-9
  • Chowdhary BP, Paria N, Raudsepp T (2008). Potential applications of equine genomics in dissecting diseases and fertility. ANIM REPROD SCI. 3-4, 208-18
  • Goh G, Raudsepp T, Durkin K, Wagner ML, Schäffer AA, Agarwala R, Tozaki T, Mickelson JR, Chowdhary BP (2007). High-resolution gene maps of horse chromosomes 14 and 21: additional insights into evolution and rearrangements of HSA5 homologs in mammals. GENOMICS. 1, 89-112
  • Brinkmeyer-Langford C, Raudsepp T, Lee EJ, Goh G, Schäffer AA, Agarwala R, Wagner ML, Tozaki T, Skow LC, Womack JE, Mickelson JR, Chowdhary BP (2005). A high-resolution physical map of equine homologs of HSA19 shows divergent evolution compared with other mammals. MAMM GENOME. 8, 631-49
  • Murphy WJ, Larkin DM, Everts-van der Wind A, Bourque G, Tesler G, Auvil L, Beever JE, Chowdhary BP, Galibert F, Gatzke L, Hitte C, Meyers SN, Milan D, Ostrander EA, Pape G, Parker HG, Raudsepp T, Rogatcheva MB, Schook LB, Skow LC, Welge M, Womack JE, O'brien SJ, Pevzner PA, Lewin HA (2005). Dynamics of mammalian chromosome evolution inferred from multispecies comparative maps. SCIENCE. 5734, 613-7
  • Gustafson-Seabury A, Raudsepp T, Goh G, Kata SR, Wagner ML, Tozaki T, Mickelson JR, Womack JE, Skow LC, Chowdhary BP (2005). High-resolution RH map of horse chromosome 22 reveals a putative ancestral vertebrate chromosome. GENOMICS. 2, 188-200
  • Raudsepp T, Santani A, Wallner B, Kata SR, Ren C, Zhang HB, Womack JE, Skow LC, Chowdhary BP (2004). A detailed physical map of the horse Y chromosome. PROC NATL ACAD SCI U S A. 25, 9321-6
  • Raudsepp T, Lee EJ, Kata SR, Brinkmeyer C, Mickelson JR, Skow LC, Womack JE, Chowdhary BP (2004). Exceptional conservation of horse-human gene order on X chromosome revealed by high-resolution radiation hybrid mapping. PROC NATL ACAD SCI U S A. 8, 2386-91
  • Gustafson AL, Tallmadge RL, Ramlachan N, Miller D, Bird H, Antczak DF, Raudsepp T, Chowdhary BP, Skow LC (2003). An ordered BAC contig map of the equine major histocompatibility complex. CYTOGENET GENOME RES. 1-4, 189-95
  • Lee EJ, Raudsepp T, Kata SR, Adelson D, Womack JE, Skow LC, Chowdhary BP (2004). A 1.4-Mb interval RH map of horse chromosome 17 provides detailed comparison with human and mouse homologues. GENOMICS. 2, 203-15
  • Chowdhary BP, Raudsepp T, Kata SR, Goh G, Millon LV, Allan V, Piumi F, Guérin G, Swinburne J, Binns M, Lear TL, Mickelson J, Murray J, Antczak DF, Womack JE, Skow LC (2003). The first-generation whole-genome radiation hybrid map in the horse identifies conserved segments in human and mouse genomes. GENOME RES. 4, 742-51
  • Raudsepp T, Houck ML, O'Brien PC, Ferguson-Smith MA, Ryder OA, Chowdhary BP (2002). Cytogenetic analysis of California condor (Gymnogyps californianus) chromosomes: comparison with chicken (Gallus gallus) macrochromosomes. CYTOGENET GENOME RES. 1, 54-60
  • Santani A, Raudsepp T, Chowdhary BP (2002). Interstitial telomeric sites and NORs in Hartmann's zebra (Equus zebra hartmannae) chromosomes. CHROMOSOME RES. 7, 527-34
  • Raudsepp T, Kata SR, Piumi F, Swinburne J, Womack JE, Skow LC, Chowdhary BP (2002). Conservation of gene order between horse and human X chromosomes as evidenced through radiation hybrid mapping. GENOMICS. 3, 451-7
  • Raudsepp T, Mariat D, Guérin G, Chowdhary BP (2001). Comparative FISH mapping of 32 loci reveals new homologous regions between donkey and horse karyotypes. CYTOGENET CELL GENET. 3-4, 180-5
  • Raudsepp T, Chowdhary BP (2001). Correspondence of human chromosomes 9, 12, 15, 16, 19 and 20 with donkey chromosomes refines homology between horse and donkey karyotypes. CHROMOSOME RES. 8, 623-9
  • Chowdhary BP, Raudsepp T (2001). Chromosome painting in farm, pet and wild animal species. METHODS CELL SCI. 1-3, 37-55
  • Avila F, Baily MP, Perelman P, Das PJ, Pontius J, Chowdhary R, Owens E, Johnson WE, Merriwether DA, Raudsepp T (2015). A comprehensive whole genome integrated cytogenetic map for the alpaca (Lama pacos) CYTOGENETICS AND GENOME RESEARCH .
  • David J Fenn, Terje Raudsepp, Ernest G Cothran, Natasha A Hamilton, Bianca Haase (2016). Validation of a candidate causative mutation for white spotting in donkeys. ANIMAL GENETICS.
  • Nima Rafati, Lisa S Andersson, Sofia Mikko, Chungang Feng, Terje Raudsepp, Jessica Pettersson, Jan Janecka, Ove Wattle, Adam Ameur, Gunilla Thyreen, John Eberth, John Huddleston, Maika Malig, Ernest Bailey, Evan E Eichler, Göran Dalin, Bhanu Chowdary, Leif Andersson, Gabriella Lindgren, Carl-Johan Rubin (2016). Large Deletions at the SHOX Locus in the Pseudoautosomal Region Are Associated with Skeletal Atavism in Shetland Ponies. G3 (BETHESDA, MD.). 7, 2213-23
  • H J Kjöllerström, M do Mar Oom, B P Chowdhary, T Raudsepp (2016). Fertility Assessment in Sorraia Stallions by Sperm-Fish and Fkbp6 Genotyping. REPRODUCTION IN DOMESTIC ANIMALS = ZUCHTHYGIENE. 3, 351-9
  • S Ghosh, P J Das, C M McQueen, V Gerber, C E Swiderski, J-P Lavoie, B P Chowdhary, T Raudsepp (2016). Analysis of genomic copy number variation in equine recurrent airway obstruction (heaves). ANIMAL GENETICS. 3, 334-44
  • E A Staiger, M A Al Abri, K M Pflug, S E Kalla, D M Ainsworth, D Miller, T Raudsepp, N B Sutter, S A Brooks (2016). Skeletal variation in Tennessee Walking Horses maps to the LCORL/NCAPG gene region. PHYSIOLOGICAL GENOMICS. 5, 325-35
  • Cassandra Seibold-Torres, Elaine Owens, Renuka Chowdhary, Malcolm A Ferguson-Smith, Ian Tizard, Terje Raudsepp (2016). Comparative Cytogenetics of the Congo African Grey Parrot (Psittacus erithacus). CYTOGENETIC AND GENOME RESEARCH. 2-3, 144-53
  • Terje Raudsepp, Bhanu P Chowdhary (2016). Chromosome Aberrations and Fertility Disorders in Domestic Animals. ANNUAL REVIEW OF ANIMAL BIOSCIENCES., 15-43
  • Terje Raudsepp, Bhanu P Chowdhary (2016). The Eutherian Pseudoautosomal Region. CYTOGENETIC AND GENOME RESEARCH. 2-3, 81-94
  • S Ghosh, P J Das, F Avila, B K Thwaits, B P Chowdhary, T Raudsepp (2016). A Non-Reciprocal Autosomal Translocation 64,XX, t(4;10)(q21;p15) in an Arabian Mare with Repeated Early Embryonic Loss. REPRODUCTION IN DOMESTIC ANIMALS = ZUCHTHYGIENE. 1, 171-4
  • Lear TL, Raudsepp T, Lundquist JM, Brown SE (2014). Repeated Early Embryonic Loss in a Thoroughbred Mare with a Chromosomal Translocation [64,XX,t(2;13)]. J EQUINE VET SCI, 34, 805–809.
  • Ghosh S, Das PJ, Arnold C, Jaxheimer J, Varner DD, Chowdhary BP, Raudsepp T (2014). Contribution of DNA copy number variants to equine cryptorchidism JOURNAL OF EQUINE VETERINARY SCIENCE 34, 29.
  • Wang, F., Ekiert. D.E., Ahmad, I., Li, W., Zhang, Y., Bazirgan, O., Torkamani, A., Raudsepp, T., Waithaka, M, Criscitiello, M.F., Wilson, I.A., Schultz, P.G., Vaughn V. Smider, V.V. (2013). Reshaping antibody diversity. CELL 153, 1379–1393. RECEIVED JOURNAL COVER..
  • Ghosh S, Qu Z, Das PJ, Fang E, Juras R, Cothran EG, McDonell S, Kenney DG, Lear TL, Adelson DL, Chowdhary BP, Raudsepp T (2014). Copy number variation in the horse genome. PLOS GENET. 10,
  • Al-Jaru A, Goodwin W, Skidmore J, Raudsepp T, Khazanehdari K (2014). Male horse meiosis: metaphase I chromosome configuration and chiasmata distribution. CYTOGENET GENOME RES. 4, 225-31
  • Li G, Davis BW, Raudsepp T, Pearks Wilkerson AJ, Mason VC, Ferguson-Smith M, O'Brien PC, Waters PD, Murphy WJ (2013). Comparative analysis of mammalian Y chromosomes illuminates ancestral structure and lineage-specific evolution. GENOME RES. 9, 1486-95
  • Das PJ, Mishra DK, Ghosh S, Avila F, Johnson GA, Chowdhary BP, Raudsepp T (2013). Comparative organization and gene expression profiles of the porcine pseudoautosomal region. CYTOGENET GENOME RES. 1, 26-36
  • Seabury CM, Dowd SE, Seabury PM, Raudsepp T, Brightsmith DJ, Liboriussen P, Halley Y, Fisher CA, Owens E, Viswanathan G, Tizard IR (2013). A multi-platform draft de novo genome assembly and comparative analysis for the Scarlet Macaw (Ara macao). PLOS ONE. 5,
  • Das PJ, McCarthy F, Vishnoi M, Paria N, Gresham C, Li G, Kachroo P, Sudderth AK, Teague S, Love CC, Varner DD, Chowdhary BP, Raudsepp T (2013). Stallion sperm transcriptome comprises functionally coherent coding and regulatory RNAs as revealed by microarray analysis and RNA-seq. PLOS ONE. 2,
  • Raudsepp T, McCue ME, Das PJ, Dobson L, Vishnoi M, Fritz KL, Schaefer R, Rendahl AK, Derr JN, Love CC, Varner DD, Chowdhary BP (2012). Genome-wide association study implicates testis-sperm specific FKBP6 as a susceptibility locus for impaired acrosome reaction in stallions. PLOS GENET. 12,
  • Stafuzza NB, Greco AJ, Grant JR, Abbey CA, Gill CA, Raudsepp T, Skow LC, Womack JE, Riggs PK, Amaral ME (2013). A high-resolution radiation hybrid map of the river buffalo major histocompatibility complex and comparison with BoLA. ANIM GENET. 4, 369-76
  • Avila F, Das PJ, Kutzler M, Owens E, Perelman P, Rubes J, Hornak M, Johnson WE, Raudsepp T (2014). Development and application of camelid molecular cytogenetic tools. J HERED. 6, 858-69
  • Fellows E, Kutzler M, Avila F, Das PJ, Raudsepp T (2014). Ovarian dysgenesis in an alpaca with a minute chromosome 36. J HERED. 6, 870-4
  • Paria N, Raudsepp T, Pearks Wilkerson AJ, O'Brien PC, Ferguson-Smith MA, Love CC, Arnold C, Rakestraw P, Murphy WJ, Chowdhary BP (2011). A gene catalogue of the euchromatic male-specific region of the horse Y chromosome: comparison with human and other mammals. PLOS ONE. 7,
  • Das PJ, Paria N, Gustafson-Seabury A, Vishnoi M, Chaki SP, Love CC, Varner DD, Chowdhary BP, Raudsepp T (2010). Total RNA isolation from stallion sperm and testis biopsies. THERIOGENOLOGY. 6, 1099-1106
  • Di Meo GP, Perucatti A, Peretti V, Incarnato D, Ciotola F, Liotta L, Raudsepp T, Di Berardino D, Chowdhary B, Iannuzzi L (2009). The 450-band resolution G- and R-banded standard karyotype of the donkey (Equus asinus, 2n = 62). CYTOGENET GENOME RES. 4, 266-71
  • Alizadeh A, Hong LZ, Kaelin CB, Raudsepp T, Manuel H, Barsh GS (2009). Genetics of Sex-linked yellow in the Syrian hamster. GENETICS. 4, 1427-36
  • Brinkmeyer-Langford C, Raudsepp T, Gustafson-Seabury A, Chowdhary BP (2008). A BAC contig map over the proximal approximately 3.3 Mb region of horse chromosome 21. CYTOGENET GENOME RES. 1-2, 164-72
  • Chiang HI, Zhou H, Raudsepp T, Jesudhasan PR, Zhu JJ (2007). Chicken CD69 and CD94/NKG2-like genes in a chromosomal region syntenic to mammalian natural killer gene complex. IMMUNOGENETICS. 7, 603-11
  • Murphy WJ, Pearks Wilkerson AJ, Raudsepp T, Agarwala R, Schäffer AA, Stanyon R, Chowdhary BP (2006). Novel gene acquisition on carnivore Y chromosomes. PLOS GENET. 3,
  • Carbone L, Nergadze SG, Magnani E, Misceo D, Francesca Cardone M, Roberto R, Bertoni L, Attolini C, Francesca Piras M, de Jong P, Raudsepp T, Chowdhary BP, Guérin G, Archidiacono N, Rocchi M, Giulotto E (2006). Evolutionary movement of centromeres in horse, donkey, and zebra. GENOMICS. 6, 777-82
  • Swinburne JE, Boursnell M, Hill G, Pettitt L, Allen T, Chowdhary B, Hasegawa T, Kurosawa M, Leeb T, Mashima S, Mickelson JR, Raudsepp T, Tozaki T, Binns M (2006). Single linkage group per chromosome genetic linkage map for the horse, based on two three-generation, full-sibling, crossbred horse reference families. GENOMICS. 1, 1-29
  • Romano JE, Raudsepp T, Mulon PY, Villadóniga GB (2015). Non-mosaic monosomy 59,X in cattle: a case report ANIMAL REPRODUCTION SCIENCE . 156, 83
  • Terje Raudsepp (2015). A Chromosome Map of the Alpaca Genome ALPACA WORLD MAGAZINE.
  • Sarah Jean Webb, Gregory V. Zychowski, Sandy W. Bauman, Benjamin M. Higgins, Terje Raudsepp, Lauren S. Gollahon, Kimberly J. Wooten, Jennifer M. Cole, and Céline A.J. Godard-Codding (2014). Establishment, Characterization, and Toxicological Application of Loggerhead Sea Turtle (Caretta caretta) Primary Skin Fibroblast Cell Cultures ENVIRON. SCI. TECHNOL. 24,
  • Felipe Avila, Malorie P. Baily, David A. Merriwether, Vladimir A. Trifonov, Jiři Rubes, Michelle A. Kutzler, Renuka Chowdhary, Jan Janečka, Terje Raudsepp (2015). A cytogenetic and comparative map of camelid chromosome 36 and the minute in alpacas CHROMOSOME RESEARCH. 23, 237
  • Terje Raudsepp (2015). Alpaca Chromosomes and Gene mapping ALPACAS MAGAZINE., 32-35

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