Gladys Ko
Professor Department of Veterinary Integrative BiosciencesResearch and Scholarly Interests
Mechanisms underlying the health and diseases of the eyes.
Synaptic plasticity in the brain.
Neuro-vascular interactions.
Interactions between neural and immune systems.
Short Bio
After getting my B.S. in Biology and M.S. in Anatomical Sciences in Taiwan, I flied across the Pacific to Ohio, US to get more advanced research training. I obtained my Ph.D. in Biomedical Sciences with a major in Neuroscience and a minor in Pharmacology, and my dissertation focused on the mechanisms of anti-epileptic drugs in the brain. I continued to pursue research in the brain synaptic plasticity during my first postdoctoral training, followed by a complete research switch to study how circadian clock regulates the retinal photoreceptors. After coming to Texas A&M, I continued to investigate the molecular mechanisms underlying the circadian regulation of retina physiology. Interestingly, a lot of these molecules under the circadian control are changed by the disease states, so my laboratory expanded our research to investigate various eye diseases, including diabetic retinopathy, retinopathy of prematurity, and macular degeneration. During this time, my laboratory discovered an endogenous peptide, “peptide Lv”. Peptide Lv is able to augment the function of photoreceptors and cardiomyocytes. In addition, peptide Lv promotes developmental and pathological angiogenesis. Thus, my laboratory has two major lines of research: 1. Discovery of disease-mechanisms and potential treatments of retinopathies; 2. Continued Investigation on the action of peptide Lv and its implications in health and diseases.
Websites
Center for Biological Clocks Research
Texas A&M Institute for Neuroscience
Texas A&M Chapter of the Society for Neuroscience
Texas A&M Nutrition Obesity Research Center
Education
BS National Chang-Kung University, Taiwan, 1989
MS National Yang-Ming Medical College, Taiwan, 1991
PhD Kent State U. affiliated w/ N.E. Ohio U Col. Med, 1996
Honors and Awards
Texas A&M University Institute for Neuroscience Service Award, from TAMIN, TAMU and Health Science Center, 2013-2014.
Montague Scholar for Excellence in Undergraduate Teaching, TAMU, 2007.
NIH Individual National Research Service Award, Sep. 2001 – July, 2004.
Professional Organizations
International Society for Eye Research
European Biological Rhythms Society
Association for Research in Vision and Ophthalmology
Society for Neuroscience
American Heart Association
American Physiological Society
Service
External/Professional/National/International:
Mentor, Association for Research in Vision and Ophthalmology (ARVO) Global Mentorship Program; 2017-2018.
Neuroscientist-Teacher Partner Program of Society for Neuroscience (SfN); 2007-2018.
President, Texas A&M Chapter of the Society for Neuroscience (SfN-TAMU); 2013-2014.
Councilor (elected), Texas A&M Chapter of the Society for Neuroscience (SfN-TAMU); 2009 – 2013; 2015-2019.
University Level:
Faculty Advisor, American Student Association (TASA), 8/2022-current.
Executive Committee Member, Texas A&M Institute for Neuroscience (TAMIN); 9/2017-11/2019; 9/2020-9/2025.
Chair, Graduate Program Committee, TAMIN; 9/2017 – 11/2019; 9/2023 – 12/2025.
Chair, Undergraduate Program Committee, TAMIN; 9/2020-9/2022.
Committee Member, Graduate Program Committee, TAMIN; 2007 – 8/2017; 9/2019-8/2023; 1/2026-current.
Committee Member, Expended Undergraduate Curriculum Committee for Neuroscience Majors (representing CVMBS); 10/2017-9/2019.
Committee Member, Undergraduate Program Committee, TAMIN; 2007 – 9/2020.
Executive Committee Member, Texas A&M Nutrition Obesity Research Center (TAMNORC); 9/2014-2016.
College Level:
Co-Leader, Physiology & Developmental Biology Track, Graduate Instruction Committee, CVMBS, 6/2024-current.
CVM and VIBS co-representative, Neuroscience-Translational and Preclinical (NRSC-TPC) undergraduate majors; 2020-7/2022.
Champion for Taiwan-TAMU relationship, International Program at CVMBS-TAMU, 2017-current.
Department Level:
Committee Member, Teaching Committee; 2006-current.
Committee Member, Departmental Committee for Promotion and Tenure (P&T); 7/2020-current.
Committee Member, Departmental Post-Tenure Review Committee; 2/2026-current.
Neuroscience
Physiology
Ophthalmology and Visual Neuroscience
Toxicology
Molecular and Cellular Biology
Chronobiology
My research laboratory investigates the cellular and molecular mechanisms that regulate retinal physiology in health and diseases, with a focus on diabetic retinopathy (DR), retinopathy of prematurity (ROP), and age-related macular degeneration (AMD). We discovered a novel bioactive peptide, “peptide Lv”, that is important in maintaining adult retinal structure and function. Peptide Lv is able to promote neural activities and angiogenesis as well as exacerbate pathological neovascularization. In disease states such as DR and ROP, peptide Lv is upregulated in the retina. Peptide Lv deficiency leads to photoreceptor degeneration in adults, an early sign of AMD.
VIBS 277: Essential Neuroscience
VIBS 450: Mammalian Functional Neuroanatomy
VIBS 285, 485: Direct Study
VIBS 491, 691: Research
NRSC 691: Research
My NCBI