Serum Cobalamin (Vitamin B12) and Folate
||251 - 908 ng/L
||7.7 - 24.4 µg/L
||290 - 1,500 ng/L
||9.7 - 21.6 µg/L
Turnaround: 1-2 business days after receipt of
Pancreatic function must be assessed
before these results can be interpreted since they may be abnormal
in animals with EPI.
Cobalamin: Absorbed in the distal small intestine
(specifically in the ileum). Values below the control range are
often seen in patients with EPI, bacterial overgrowth in the upper
small intestine, or disease affecting the distal small intestine.
There is no known significance of values exceeding the control
Folate: Absorbed in the proximal small intestine
only. Values above the control range are consistent with bacterial
overgrowth in the upper small intestine. Values below the control
range are consistent with disease affecting the proximal small
Dietary deficiency of cobalamin and folate is highly improbable and
even starvation of several weeks duration does not cause serum
cobalamin and folate to become subnormal in dogs. Therefore,
subnormal serum concentrations of cobalamin reflect a state of
chronic malabsorption and should be treated ( cobalamin
treatment protocol). Folate supplementation
recommendations can be found on the folate
supplementation page .
However, not all intestinal diseases causing malabsorption of
vitamins are sufficiently severe or long-standing to deplete body
stores of each vitamin. Therefore, not all dogs and cats with
intestinal diseases have abnormal test results.Also, not all dogs
with intestinal disease have intestinal morphologic
Serum folate shows limited stability at room temperature.
Therefore, serum samples for folate analysis should be kept at 4ºC
(refrigerator temperature) for not longer than 48 hours, but
freezing is preferred.
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