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Research and Publications

NOTICE: The Animal Genetics Lab will be closed from July 17-30th. We will reopen July 31st.

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Research: Biomedical Genomics

Our lab focuses on studying the heredity basis of equine congenital defects and economically significant traits in domestic animals (mainly the horse); interrelationships of inbreeding, genetic polymorphism, and reproductive performance in horses; population genetics of feral horses; comparative aspects of genetic variation in horses under human selection and under natural selection; genetic aspects of captivity; genetics of domestication. Management of genetic polymorphism in small populations and conservation of rare breeds; genetic relationship among domestic horse breeds; changes in gene regulation based upon environmental factors; gene mapping of the horse.

Publications

Journal Cover

 Australian Journal of Zoology

Microsatellite analysis of genetic variability in Waler horses from Australia. A. M. Khanshour, R. Juras and E.G. Cothran. Australian Journal of Zoology 61(5) 357-365

Selected Publications

  • The global spread of Oriental Horses in the past 1,500 years through the lens of the Y chromosome. Radovic,L., Remer, V., Rigler, D., Bozlak, E., Allen, L., Brem, G., Reissman, M., Brockmann, G.A., Ropka-Molik, K., Stefaniuk-Szmukier, M., Kalinkova, L., Kalashnikov, V.V., Zaitev, A.M., Raudsepp, T., Castaneda, C., von Butler-Wemken, I., Rosa, L.P., Brooks, S.A., Novoa‐Bravo, M., Kostaras, N., Abdurasulov, A., Antczak, D.F., Miller, D.C., Lopes, M.S., Machado, A.C., Lindgren, G., Juras, R., Cothran, G., Wallner, B. PNAS 121 (49) e2414408121. https://doi.org/10.1073/pnas.2414408121

  • Refining the evolutionary tree of the horse Y chromosome. Bozlak, E., Radovic, L., Remer, V., Rigler, D., Allen, L., Brem, G., Stalder, G., Castaneda, C., Cothran, G., Raudsepp, T., Okuda, Y., Moe, K., Moe, H., Kounnavongsa, B., Keonouchanh, S., Van, N., Vu, V., Shah, M., Nishibori, M., Kazymbet, P., Bakhtin, M., Zhunushov. A., Paul, R.., Dashnyam, B., Nozawa, K., Almarzook, S., Brockmann, G., Reissmann, M., Antczak, D., Miller, D., Sadeghi, R., von Butler-Wemken, I., Kostaras, N., Han, H., Manglai, D., Abdurasulov, A., Sukhbaatar, B., Ropka-Molik, K., Stefaniuk-Szmukier, M., Lopes, M., Câmara Machado, A., Kalashnikov, V., Kalinkova, L., Zaitev, A., Novoa‐Bravo, M., Lindgren, G., Brooks, S., Rosa, L., Orlando, L., Juras, R., Kunieda, T. & Wallner, B. Sci Rep 2023 13, 8954 https://doi.org/10.1038/s41598-023-35539-0

  • Y-Chromosomal Insights into Breeding History and Sire Line Genealogies of Arabian Horses. Remer V, Bozlak E, Felkel S, Radovic L, Rigler D, Grilz-Sege, G, Stefaniuk-Szmukier M, Bugno-Poniewierska M, Brooks S, Miller DC, Antczak DF, Sadeghi R, Cothran G, Juras R, Khanshour AM, Rieder S, Penedo MC, Waiditschka G, Kalinkova L, Kalashnikov VV, Zaitsev AM, Almarzook S, Reißmann M, Brockmann GA, Brem G, Wallner,B Genes 2022, 13, 229. https://doi.org/10.3390/genes13020229

  • Copy number variation in the horse genome. Ghosh S, Qu Z, Das PJ, Fang E, Juras R, Cothran EG, McDonell S, Kenney DG, Lear TL, Adelson DL, Chowdhary BP, Raudsepp T. PLoS Genet. 2014 Oct 23;10(10):e1004712. doi: 10.1371/journal.pgen.1004712. eCollection 2014 Oct. PMID: 25340504

  • Worldwide frequency distribution of the ‘Gait keeper’ mutation in the DMRT3 gene. Promerová M, Andersson LS, Juras R, Penedo MC, Reissmann M, Tozaki T, Bellone R, Dunner S, Hořín P, Imsland F, Imsland P, Mikko S, Modrý D, Roed KH, Schwochow D, Vega-Pla JL, Mehrabani-Yeganeh H, Yousefi-Mashouf N, G Cothran E, Lindgren G, Andersson L. Anim Genet. 2014 Apr;45(2):274-82. doi: 10.1111/age.12120. Epub 2014 Jan 21. PMID: 24444049

  • Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice. Andersson LS, Larhammar M, Memic F, Wootz H, Schwochow D, Rubin CJ, Patra K, Arnason T, Wellbring L, Hjälm G, Imsland F, Petersen JL, McCue ME, Mickelson JR, Cothran G, Ahituv N, Roepstorff L, Mikko S, Vallstedt A, Lindgren G, Andersson L, Kullander K. Nature. 2012 Aug 30;488(7413):642-6. doi: 10.1038/nature11399. PMID: 22932389

  • Genetic diversity in the modern horse illustrated from genome-wide SNP data. Petersen JL, Mickelson JR, Cothran EG, Andersson LS, Axelsson J, Bailey E, Bannasch D, Binns MM, Borges AS, Brama P, da Câmara Machado A, Distl O, Felicetti M, Fox-Clipsham L, Graves KT, Guérin G, Haase B, Hasegawa T, Hemmann K, Hill EW, Leeb T, Lindgren G, Lohi H, Lopes MS, McGivney BA, Mikko S, Orr N, Penedo MC, Piercy RJ, Raekallio M, Rieder S, Røed KH, Silvestrelli M, Swinburne J, Tozaki T, Vaudin M, M Wade C, McCue ME. PLoS One. 2013;8(1):e54997. doi: 10.1371/journal.pone.0054997. Epub 2013 Jan 30. PMID: 23383025