Scott Dindot
Professor Department of Veterinary PathobiologyResearch and Scholarly Interests
The overarching themes of research in my laboratory are to understand the genetic and epigenetic basis of disease, with an emphasis on neurological disorders associated with genomic imprinting, a naturally occurring phenomenon that leads to the differential expression of alleles in a parent-of-origin dependent manner. We are interested in understanding why and how genes are imprinted, the function of imprinting in the brain, and the development of new therapies to treat imprinted disorders.
EDUCATION
- B.S., Texas A&M University, 1999
- Ph.D., Texas A&M University, 2003
- Neuroscience
- Genomics
- Genetics
- Education
- Paul R Hillman, Sarah G B Christian, Ryan Doan, Noah D Cohen, Kranti Konganti, Kory Douglas, Xu Wang, Paul B Samollow, Scott V Dindot (2017). Genomic imprinting does not reduce the dosage of UBE3A in neurons. EPIGENETICS & CHROMATIN., 27
- Bruna R C Alves, Rodolfo C Cardoso, Ryan Doan, Youwen Zhang, Scott V Dindot, Gary L Williams, Marcel Amstalden (2017). Nutritional programming of accelerated puberty in heifers: alterations in DNA methylation in the arcuate nucleus. BIOLOGY OF REPRODUCTION. 1, 174-184
- Nioka C Chisholm, Michael L Henderson, Amutha Selvamani, Min Jung Park, Scott Dindot, Rajesh C Miranda, Farida Sohrabji (2015). Histone methylation patterns in astrocytes are influenced by age following ischemia. EPIGENETICS. 2, 142-52
- McQueen CM, Doan R, Dindot SV, Bourquin JR, Zlatev ZZ, Chaffin MK, Blodgett GP, Ivanov I, Cohen ND (2014). Identification of genomic loci associated with Rhodococcus equi susceptibility in foals. PLOS ONE. 6
- Dindot SV, Person R, Strivens M, Garcia R, Beaudet AL (2009). Epigenetic profiling at mouse imprinted gene clusters reveals novel epigenetic and genetic features at differentially methylated regions. GENOME RES. 8, 1374-83
- Dindot SV, Antalffy BA, Bhattacharjee MB, Beaudet AL (2008). The Angelman syndrome ubiquitin ligase localizes to the synapse and nucleus, and maternal deficiency results in abnormal dendritic spine morphology. HUM MOL GENET. 1, 111-8
- Piedrahita JA, Mir B, Dindot S, Walker S (2004). Somatic cell cloning: the ultimate form of nuclear reprogramming? J AM SOC NEPHROL. 5, 1140-4
- Dindot SV, Farin PW, Farin CE, Romano J, Walker S, Long C, Piedrahita JA (2004). Epigenetic and genomic imprinting analysis in nuclear transfer derived Bos gaurus/Bos taurus hybrid fetuses. BIOL REPROD. 2, 470-8
- Archer GS, Dindot S, Friend TH, Walker S, Zaunbrecher G, Lawhorn B, Piedrahita JA (2003). Hierarchical phenotypic and epigenetic variation in cloned swine. BIOL REPROD. 2, 430-6
- Doan R, Cohen ND, Sawyer J, Ghaffari N, Johnson CD, Dindot SV (2012). Whole-Genome Sequencing and Genetic Variant Analysis of a Quarter Horse Mare. BMC GENOMICS. 1, 78
- Wang J, Wu Z, Li D, Li N, Dindot SV, Satterfield MC, Bazer FW, Wu G (2012). Nutrition, Epigenetics, and Metabolic Syndrome. ANTIOXID REDOX SIGNAL.
- Doan R, Cohen N, Harrington J, Veazey K, Juras R, Cothran G, McCue ME, Skow L, Dindot SV (2012). Identification of copy number variants in horses. GENOME RES. 5, 899-907
- Dindot S, Piccolo P, Grove N, Palmer D, Brunetti-Pierri N (2011). Intrathecal injection of helper-dependent adenoviral vectors results in long-term transgene expression in neuroependymal cells and neurons. HUM GENE THER. 6, 745-51
- Dindot SV, Kent KC, Evers B, Loskutoff N, Womack J, Piedrahita JA (2004). Conservation of genomic imprinting at the XIST, IGF2, and GTL2 loci in the bovine. MAMM GENOME. 12, 966-74
- Nycole A Copping, Sarah G B Christian, Dylan J Ritter, M Saharul Islam, Nathalie Buscher, Dorota Zolkowska, Michael C Pride, Elizabeth L Berg, Janine M LaSalle, Jacob Ellegood, Jason P Lerch, Lawrence T Reiter, Jill L Silverman, Scott V Dindot (2017). Neuronal overexpression of Ube3a isoform 2 causes behavioral impairments and neuroanatomical pathology relevant to 15q11.2-q13.3 duplication syndrome. HUMAN MOLECULAR GENETICS. 20, 3995-4010
- E M Quist, R Doan, R R Pool, B F Porter, D L Bannasch, S V Dindot (2017). Identification of a candidate mutation in the COL1A2 gene of a Chow Chow with osteogenesis imperfecta. THE JOURNAL OF HEREDITY.