M.D., Bogomolets National Medical University, 1996
Ph.D., University of North Carolina at Chapel Hill, 2000
Toxicology
Woods, Courtney G, Burns, Amanda M, Maki, Akira, Bradford, Blair U, Cunningham, Michael L, Connor, Henry D, Kadiiska, Maria B, Mason, Ronald P, Peters, Jeffrey M, Rusyn, Ivan (2007). Sustained formation of α-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts in mouse liver by peroxisome proliferators is dependent upon peroxisome proliferator-activated receptor-α, but not NADPH oxidase FREE RADICAL BIOLOGY AND MEDICINE. 3, 335-342
Blackwleder, AJ, Ma, Z, Li, X, Rusyn, I, Yang, X (2014). ADULT EXPOSURE TO ALCOHOL PROMOTES MAMMARY TUMOR DEVELOPMENT IN MMTV-ERBB-2 TRANSGENIC MICE THROUGH ACTIVATION OF ER, AKT AND ERK1/2 SIGNALING ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH. , 109A-109A
Politi, Regina, Rusyn, Ivan, Tropsha, Alexander (2014). Prediction of binding affinity and efficacy of thyroid hormone receptor ligands using QSAR and structure-based modeling methods TOXICOLOGY AND APPLIED PHARMACOLOGY. 1, 177-189
Uehara, Takeki, Pogribny, Igor P, Rusyn, Ivan (2014). The DEN and CCl4‐induced mouse model of fibrosis and inflammation‐associated hepatocellular carcinoma CURRENT PROTOCOLS IN PHARMACOLOGY. 1, 14.30. 1-14.30. 10
Chappell, Grace, Kobets, Tetyana, O’brien, Bridget, Tretyakova, Natalia, Sangaraju, Dewakar, Kosyk, Oksana, Sexton, Kenneth G, Bodnar, Wanda, Pogribny, Igor P, Rusyn, Ivan (2014). Epigenetic events determine tissue-specific toxicity of inhalational exposure to the genotoxic chemical 1, 3-butadiene in male C57BL/6J mice TOXICOLOGICAL SCIENCES. 2, 375-384
Marrone, April K, Tryndyak, Volodymyr, Chappell, Grace, Beland, Frederick A, Rusyn, Ivan, Pogribny, Igor P (2014). The microRNA profile is altered in fibrosis-associated hepatocarcinogenesis in mice . ,
Chiu, Weihsueh A, Guyton, Kathryn Z, Martin, Matthew T, Reif, David M, Rusyn, Ivan (2018). Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups ALTEX. 1, 51
Sakolish, Courtney, Weber, Elijah J, Kelly, Edward J, Himmelfarb, Jonathan, Mouneimne, Roula, Grimm, Fabian A, House, John S, Wade, Terry, Han, Arum, Chiu, Weihsueh A (2018). Technology transfer of the microphysiological systems: a case study of the human proximal tubule tissue chip SCIENTIFIC REPORTS. 1, 14882
Shapiro, Andrew J, Antoni, Sébastien, Guyton, Kathryn Z, Lunn, Ruth M, Loomis, Dana, Rusyn, Ivan, Jahnke, Gloria D, Schwingl, Pamela J, Mehta, Suril S, Addington, Josh (2018). Software Tools to Facilitate Systematic Review Used for Cancer Hazard Identification ENVIRONMENTAL HEALTH PERSPECTIVES. 10, 104501
Blanchette, Alexander D, Grimm, Fabian A, Dalaijamts, Chimedullam, Hsieh, Nan‐Hung, Ferguson, Kyle, Luo, Yu‐Syuan, Rusyn, Ivan, Chiu, Weihsueh A (2018). Thorough QT/QTc in a Dish: An In Vitro Human Model That Accurately Predicts Clinical Concentration‐QTc Relationships CLINICAL PHARMACOLOGY & THERAPEUTICS. ,
Low, Yen S, Alves, Vinicius M, Fourches, Denis, Sedykh, Alexander, Andrade, Carolina Horta, Muratov, Eugene N, Rusyn, Ivan, Tropsha, Alexander (2018). Chemistry-Wide Association Studies (CWAS): A Novel Framework for Identifying and Interpreting Structure–Activity Relationships JOURNAL OF CHEMICAL INFORMATION AND MODELING. 11, 2203-2213
Grimm, Fabian A, House, John S, Wilson, Melinda R, Sirenko, Oksana, Iwata, Yasuhiro, Wright, Fred A, Ball, Nicholas, Rusyn, Ivan (2019). Multi-dimensional in vitro bioactivity profiling for grouping of glycol ethers REGULATORY TOXICOLOGY AND PHARMACOLOGY. , 91-102
Alves, Vinicius M, Borba, Joyce, Capuzzi, Stephen J, Muratov, Eugene, Andrade, Carolina H, Rusyn, Ivan, Tropsha, Alexander (2018). Oy Vey! A Comment on “Machine Learning of Toxicological Big Data Enables Read-Across Structure Activity Relationships Outperforming Animal Test Reproducibility” TOXICOLOGICAL SCIENCES. 1, 3-4
Furuya, Shinji, Cichocki, Joseph A, Konganti, Kranti, Dreval, Kostiantyn, Uehara, Takeki, Katou, Yuuki, Fukushima, Hisataka, Kono, Hiroshi, Pogribny, Igor P, Argemi, Josepmaria (2018). Histopathological and Molecular Signatures of a Mouse Model of Acute-on-Chronic Alcoholic Liver Injury Demonstrate Concordance With Human Alcoholic Hepatitis TOXICOLOGICAL SCIENCES. ,
Lewis, Lauren, Chappell, Grace A, Kobets, Tetyana, O’Brian, Bridget E, Sangaraju, Dewakar, Kosyk, Oksana, Bodnar, Wanda, Tretyakova, Natalia Y, Pogribny, Igor P, Rusyn, Ivan (2018). Sex-specific differences in genotoxic and epigenetic effects of 1, 3-butadiene among mouse tissues ARCHIVES OF TOXICOLOGY. , 1-10
Pearce, Neil, Blair, Aaron, Vineis, Paolo, Ahrens, Wolfgang, Andersen, Aage, Anto, Josep M, Armstrong, Bruce K, Baccarelli, Andrea A, Beland, Frederick A, Berrington, Amy (2015). IARC Monographs ENVIRONMENTAL HEALTH PERSPECTIVES. ,
Koturbash, Igor, Scherhag, Anne, Sorrentino, Jessica, Sexton, Kenneth, Bodnar, Wanda, Tryndyak, Volodymyr, Latendresse, John R, Swenberg, James A, Beland, Frederick A, Pogribny, Igor P (2010). Epigenetic alterations in liver of C57BL/6J mice after short-term inhalational exposure to 1, 3-butadiene ENVIRONMENTAL HEALTH PERSPECTIVES. 5, 635-640
Bradford, Blair U, Lock, Eric F, Kosyk, Oksana, Kim, Sungkyoon, Uehara, Takeki, Harbourt, David, DeSimone, Michelle, Threadgill, David W, Tryndyak, Volodymyr, Pogribny, Igor P (2010). Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice TOXICOLOGICAL SCIENCES. 1, 206-217
Yamashina, Shunhei, Ikejima, Kenichi, Rusyn, Ivan, Sato, Nobuhiro (2007). Glycine as a potent anti‐angiogenic nutrient for tumor growth JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. , S62-S64
Cowerd, Rachael B, Asmar, Melissa M, Alderman, J McKee, Alderman, Elizabeth A, Garland, Alaina L, Busby, Walker H, Bodnar, Wanda M, Rusyn, Ivan, Medoff, Benjamin D, Tisch, Roland (2010). Adiponectin lowers glucose production by increasing SOGA THE AMERICAN JOURNAL OF PATHOLOGY. 4, 1936-1945
Jeannot, Emmanuelle, Mellottee, Lucille, Bioulac-Sage, Paulette, Balabaud, Charles, Scoazec, Jean-Yves, Van Nhieu, Jeanne Tran, Bacq, Yannick, Michalak, Sophie, Buob, David, Laurent-Puig, Pierre (2010). Spectrum of HNF1A somatic mutations in hepatocellular adenoma differs from that in patients with MODY3 and suggests genotoxic damage DIABETES. 7, 1836-1844
Martinez, Stephanie M, Bradford, Blair U, Soldatow, Valerie Y, Kosyk, Oksana, Sandot, Amelia, Witek, Rafal, Kaiser, Robert, Stewart, Todd, Amaral, Kirsten, Freeman, Kimberly (2010). Evaluation of an in vitro toxicogenetic mouse model for hepatotoxicity TOXICOLOGY AND APPLIED PHARMACOLOGY. 3, 208-216
Lock, Eric F, Abdo, Nour, Huang, Ruili, Xia, Menghang, Kosyk, Oksana, O’shea, Shannon H, Zhou, Yi-Hui, Sedykh, Alexander, Tropsha, Alexander, Austin, Christopher P (2012). Quantitative High-Throughput Screening for Chemical Toxicity in a Population-Based In V itro Model TOXICOLOGICAL SCIENCES. 2, 578-588
Gatti, Daniel M, Zhao, Ni, Chesler, Elissa J, Bradford, Blair U, Shabalin, Andrey A, Yordanova, Roumyana, Lu, Lu, Rusyn, Ivan (2010). Sex-specific gene expression in the BXD mouse liver PHYSIOLOGICAL GENOMICS. 3, 456-468
Koturbash, Igor, Scherhag, Anne, Sorrentino, Jessica, Sexton, Kenneth, Bodnar, Wanda, Swenberg, James A, Beland, Frederick A, Pardo-Manuel deVillena, Fernando, Rusyn, Ivan, Pogribny, Igor P (2011). Epigenetic mechanisms of mouse interstrain variability in genotoxicity of the environmental toxicant 1, 3-butadiene TOXICOLOGICAL SCIENCES. 2, 448-456
Jeannot, Emmanuelle, Boorman, Gary A, Kosyk, Oksana, Bradford, Blair U, Shymoniak, Svitlana, Tumurbaatar, Batbayar, Weinman, Steven A, Melnyk, Stepan B, Tryndyak, Volodymyr, Pogribny, Igor P (2012). Increased incidence of aflatoxin B1‐induced liver tumors in hepatitis virus C transgenic mice INTERNATIONAL JOURNAL OF CANCER. 6, 1347-1356
Rusyn, Ivan, Peters, Jeffrey M, Cunningham, Michael L (2006). Effects of DEHP in the liver: modes of action and species-specific differences CRITICAL REVIEWS IN TOXICOLOGY. 5, 459
Sirenko, Oksana, Hesley, Jayne, Rusyn, Ivan, Cromwell, Evan F (2014). High-content high-throughput assays for characterizing the viability and morphology of human iPSC-derived neuronal cultures ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES. 9-10, 536-547
Wheeler, Michael D, Smutney, Olivia M, Check, Jennifer F, Rusyn, Ivan I, Schulte-Hermann, Rolf, Thurman, Ronald G (2002). Impaired Ras membrane-association and activation in PPARα knockout mice following partial hepatectomy AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. ,
Perry, Amie, Lynch, Rachel M, Rusyn, Ivan, Threadgill, David W (2019). Long-Term Combinatorial Exposure to Trichloroethylene and Inorganic Arsenic in Genetically Heterogeneous Mice Results in Renal Tubular Damage and Cancer-Associated Molecular Changes G3: GENES, GENOMES, GENETICS. , g3. 400161.2019
KEELE, GREGORY R, Quach, Bryan C, Israel, Jennifer W, Zhou, Yihui, Chappell, Grace A, Lewis, Lauren, Safi, Alexias, Simon, Jeremy M, Cotney, Paul, Crawford, Gregory E (2019). Integrative QTL analysis of gene expression and chromatin accessibility identifies multi-tissue patterns of genetic regulation BIORXIV. , 588723
Iwata, Yasuhiro, Klaren, William D, Lebakken, Connie S, Grimm, Fabian A, Rusyn, Ivan (2017). High-content assay multiplexing for vascular toxicity screening in induced pluripotent stem cell-derived endothelial cells and human umbilical vein endothelial cells ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES. 6, 267-279
Furuya, Shinji, Uehara, Takeki, Kato, Yuki, Kosyk, Oksana, Odena, Gemma, Kono, Hiroshi, Bataller, Ramon, Rusyn, Ivan (2014). severe liver and kidney injury in mouse models of acute-on-chronic alcoholic hepatitis: 1078 HEPATOLOGY. , 724A
HongSik Yoo, Blair U Bradford, Oksana Kosyk, Takeki Uehara, Svitlana Shymonyak, Leonard B Collins, Wanda M Bodnar, Louise M Ball, Avram Gold, Ivan Rusyn (2015). Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: liver effects JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, PART A. 1, 15-31
Kono, H (1999). Kupffer cell NADPH oxidase plays an important role in early alcohol-induced liver injury in mice HEPATOLOGY. , 336
Gatti, Daniel M, Sypa, Myroslav, Rusyn, Ivan, Wright, Fred A, Barry, William T (2008). SAFEGUI: resampling-based tests of categorical significance in gene expression data made easy BIOINFORMATICS. 4, 541-542
Rusyn, Ivan, Sedykh, Alexander, Low, Yen, Guyton, Kathryn Z, Tropsha, Alexander (2012). Predictive modeling of chemical hazard by integrating numerical descriptors of chemical structures and short-term toxicity assay data TOXICOLOGICAL SCIENCES. 1, 1-9
Rusyn, I, Kadiiska, MB, Dikalova, A, Kono, H, Mason, RP, Thurman, RG (1999). Phthalates rapidly increase reactive oxygen species in vivo FREE RADICAL BIOLOGY AND MEDICINE. 27, S148
Rusyn, Ivan, Corton, J Christopher (2012). Mechanistic considerations for human relevance of cancer hazard of di (2-ethylhexyl) phthalate MUTATION RESEARCH/REVIEWS IN MUTATION RESEARCH. 2, 141-158
Jeannot, Emmanuelle, Pogribny, Igor P, Beland, Frederick A, Rusyn, Ivan (2011). Chronic administration of ethanol leads to an increased incidence of hepatocellular adenoma by promoting H-ras-mutated cells CANCER LETTERS. 2, 161-167
Gatti, Daniel M, Lu, Lu, Williams, Robert W, Sun, Wei, Wright, Fred A, Threadgill, David W, Rusyn, Ivan (2011). MicroRNA expression in the livers of inbred mice MUTATION RESEARCH/FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 1-2, 126-133
Stotts, David, Lee, Keith, Rusyn, Ivan (2008). Supporting computational systems science: Genomic analysis tool federations using aspects and aop INTERNATIONAL SYMPOSIUM ON BIOINFORMATICS RESEARCH AND APPLICATIONS. , 457-468
Pogribny, Igor P, Rusyn, Ivan (2014). Role of epigenetic aberrations in the development and progression of human hepatocellular carcinoma CANCER LETTERS. 2, 223-230
Abdo, Nour, Xia, Menghang, Brown, Chad C, Kosyk, Oksana, Huang, Ruili, Sakamuru, Srilatha, Zhou, Yi-Hui, Jack, John R, Gallins, Paul, Xia, Kai (2015). Population-based in vitro hazard and concentration–response assessment of chemicals: the 1000 genomes high-throughput screening study ENVIRONMENTAL HEALTH PERSPECTIVES. 5, 458-466
Politi, Regina, Rusyn, Ivan, Tropsha, Alexander (2014). Prediction of binding affinity and efficacy of thyroid hormone receptor ligands using QSAR and structure-based modeling methods TOXICOLOGY AND APPLIED PHARMACOLOGY. , 177-189
Tsuchiya, Masato, Ji, Cheng, Kosyk, Oksana, Shymonyak, Svitlana, Melnyk, Stepan, Kono, Hiroshi, Tryndyak, Volodymyr, Muskhelishvili, Levan, Pogribny, Igor P, Kaplowitz, Neil (2012). Interstrain differences in liver injury and one‐carbon metabolism in alcohol‐fed mice HEPATOLOGY. 1, 130-139
Weis, BK, Toxicogenomics Research Consortium (2005). Standardizing global gene expression analysis between laboratories and across platforms NATURE METHODS. 5, 351
Yeatts, Karin B, El-Sadig, Mohamed, Leith, David, Kalsbeek, William, Al-Maskari, Fatma, Couper, David, Funk, William E, Zoubeidi, Taoufik, Chan, Ronna L, Trent, Chris B (2012). Indoor air pollutants and health in the United Arab Emirates ENVIRONMENTAL HEALTH PERSPECTIVES. 5, 687-694
Hakenewerth, Anne M, Millikan, Robert C, Rusyn, Ivan, Herring, Amy H, North, Kari E, Barnholtz-Sloan, Jill S, Funkhouser, William F, Weissler, Mark C, Olshan, Andrew F (2011). Joint effects of alcohol consumption and polymorphisms in alcohol and oxidative stress metabolism genes on risk of head and neck cancer CANCER EPIDEMIOLOGY AND PREVENTION BIOMARKERS. 11, 2438-2449
Rusyn, I, Segal, B, Holland, SM, Thurman, RG (1998). NADPH oxidase is the source of oxidants for activation of NF-κB by the peroxisome proliferator WY-14,643 (WY) FREE RADICAL BIOLOGY AND MEDICINE. , S118
Tryndyak, Volodymyr P, Latendresse, John R, Montgomery, Beverly, Ross, Sharon A, Beland, Frederick A, Rusyn, Ivan, Pogribny, Igor P (2012). Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline-and folate-deficient diet TOXICOLOGY AND APPLIED PHARMACOLOGY. 1, 52-59
Starlard-Davenport, Athena, Tryndyak, Volodymyr, Kosyk, Oksana, Ross, Sharon R, Rusyn, Ivan, Beland, Frederick A, Pogribny, Igor P (2010). Dietary methyl deficiency, microRNA expression and susceptibility to liver carcinogenesis PERSONALIZED NUTRITION. , 123-130
Yeatts, Karin B, El-Sadig, Mohamed, Ali, Habiba I, Al-Maskari, Fatma, Campbell, Alan, Ng, Shu Wen, Reeves, Lisa, Chan, Ronna L, Davidson, Christopher A, Funk, William E (2012). Conducting environmental health research in the Arabian Middle East: lessons learned and opportunities ENVIRONMENTAL HEALTH PERSPECTIVES. 5, 632-636
Zhou, Yi-Hui, Cichocki, Joseph A, Soldatow, Valerie Y, Scholl, Elizabeth H, Gallins, Paul J, Jima, Dereje, Yoo, Hong-Sik, Chiu, Weihsueh A, Wright, Fred A, Rusyn, Ivan (2017). Editor’s highlight: comparative dose-response analysis of liver and kidney transcriptomic effects of trichloroethylene and tetrachloroethylene in B6C3F1 mouse TOXICOLOGICAL SCIENCES. 1, 95-110
Lewis, Lauren, Crawford, Gregory E, Furey, Terrence S, Rusyn, Ivan (2017). Genetic and epigenetic determinants of inter-individual variability in responses to toxicants CURRENT OPINION IN TOXICOLOGY. , 50-59
Rusyn, Ivan, Greene, Nigel (2017). The impact of novel assessment methodologies in toxicology on green chemistry and chemical alternatives TOXICOLOGICAL SCIENCES. 2, 276-284
House, John S, Grimm, Fabian A, Jima, Dereje D, Zhou, Yi-Hui, Rusyn, Ivan, Wright, Fred A (2017). A pipeline for high-throughput concentration response modeling of gene expression for toxicogenomics FRONTIERS IN GENETICS. , 168
Yang, Jialiang, Huang, Tao, Petralia, Francesca, Long, Quan, Zhang, Bin, Argmann, Carmen, Zhao, Yong, Mobbs, Charles V, Schadt, Eric E, Zhu, Jun (2015). Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases SCIENTIFIC REPORTS. , 15145
Furuya, Shinji, Cichocki, Joseph, Konganti, Kranti, Dreval, Kostiantyn, Uehara, Takeki, Katou, Yuuki, Kono, Hiroshi, Pogribny, Igor, Bataller, Ramon, Rusyn, Ivan (2017). Relationship between alcohol treatment and transcriptome in mouse model of acute-on-chronic alcoholic liver injury HEPATOLOGY. , 703A-703A
de Conti, Aline, Ortega, Juliana Festa, Tryndyak, Volodymyr, Dreval, Kostiantyn, Moreno, Fernando Salvador, Rusyn, Ivan, Beland, Frederick A, Pogribny, Igor P (2017). MicroRNA deregulation in nonalcoholic steatohepatitis-associated liver carcinogenesis ONCOTARGET. 51, 88517
Pogribny, Igor P, Dreval, Kostiantyn, Kindrat, Iryna, Melnyk, Stepan, Jimenez, Leandro, de Conti, Aline, Tryndyak, Volodymyr, Pogribna, Marta, Ortega, Juliana Festa, James, S Jill (2017). Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma THE FASEB JOURNAL. 3, 1591-1601
Rusyn, Ivan, Pogribny, Igor P (2017). Editorial overview of the special issue on genomic toxicology epigenetics CURRENT OPINION IN TOXICOLOGY. , i
Lewis, L, Borowa-Mazgaj, B, Chappell, GA, Luo, YS, Bodnar, W, Konganti, K, Wright, FA, Threadgill, DW, Chiu, WA, Pogribny, IP (2019). Population-based analysis of DNA damage and epigenetic effects of 1, 3-butadiene in the mouse. CHEMICAL RESEARCH IN TOXICOLOGY. ,
Moreno, M, García-Rocha, M, Altamirano, J, Affò, S, Morales-Ibanez, O, Sancho-Bru, P, Millan, C, Arroyo, V, Caballeria, J, Gines, P (2014). P343 IDENTIFICATION OF A NOVEL HEXOKINASE IN PATIENTS WITH ALCOHOLIC HEPATITIS JOURNAL OF HEPATOLOGY. 1, S181
Hatcher, Shannon E, Kosyk, Oksana, Ross, P, Wright, F, Schwartz, J, Dix, David, Rusyn, Ivan (2009). In vitro screening for chemical toxicity in a genetically-diverse human model system EPA TOXCAST DATA ANALYSIS SUMMIT, RTP, NC. ,
Pearce, Neil, Blair, Aaron, Vineis, Paolo, Ahrens, Wolfgang, Andersen, Aage, Anto, Josep M, Armstrong, Bruce K, Baccarelli, Andrea A, Beland, Frederick A, Berrington, Amy (2015). IARC monographs: 40 years of evaluating carcinogenic hazards to humans ENVIRONMENTAL HEALTH PERSPECTIVES. 6, 507-514
Marrone, April K, Shpyleva, Svitlana, Chappell, Grace, Tryndyak, Volodymyr, Uehara, Takeki, Tsuchiya, Masato, Beland, Frederick A, Rusyn, Ivan, Pogribny, Igor P (2016). Differentially expressed MicroRNAs provide mechanistic insight into fibrosis‐associated liver carcinogenesis in mice MOLECULAR CARCINOGENESIS. 5, 808-817
Berggren, Elisabet, Amcoff, Patric, Benigni, Romualdo, Blackburn, Karen, Carney, Edward, Cronin, Mark, Deluyker, Hubert, Gautier, Francoise, Judson, Richard S, Kass, Georges EN (2015). Chemical safety assessment using read-across: assessing the use of novel testing methods to strengthen the evidence base for decision making ENVIRONMENTAL HEALTH PERSPECTIVES. 12, 1232-1240
Rivas, Manuel A, Pirinen, Matti, Conrad, Donald F, Lek, Monkol, Tsang, Emily K, Karczewski, Konrad J, Maller, Julian B, Kukurba, Kimberly R, DeLuca, David S, Fromer, Menachem (2015). Effect of predicted protein-truncating genetic variants on the human transcriptome SCIENCE. 6235, 666-669
GTEx Consortium (2015). The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans SCIENCE. 6235, 648-660
Linkov, Igor, Massey, Olivia, Keisler, Jeff, Rusyn, Ivan, Hartung, Thomas (2015). From" weight of evidence" to quantitative data integration using multicriteria decision analysis and Bayesian methods ALTEX. 1, 3
Yoo, Hong Sik, Cichocki, Joseph A, Kim, Sungkyoon, Venkatratnam, Abhishek, Iwata, Yasuhiro, Kosyk, Oksana, Bodnar, Wanda, Sweet, Stephen, Knap, Anthony, Wade, Terry (2015). The contribution of peroxisome proliferator-activated receptor alpha to the relationship between toxicokinetics and toxicodynamics of trichloroethylene TOXICOLOGICAL SCIENCES. 2, 339-349
Pogribny, Igor P, Rusyn, Ivan (2013). Environmental toxicants, epigenetics, and cancer EPIGENETIC ALTERATIONS IN ONCOGENESIS. , 215-232
Rusyn, Ivan, Li, Xiangli, Raleigh, James A, Mason, Ronald P, Yin, Ronald G Ming, Zhong, Zhi, Connor, Henry D, Bunzendahl, Hartwig, Finn, William F (2002). Protective effect of glycine on renal injury induced by AM J PHYSIOL RENAL PHYSIOL. , F417-F423
Soldatow, Valerie Y, LeCluyse, Edward L, Griffith, Linda G, Rusyn, Ivan (2013). In vitro models for liver toxicity testing TOXICOLOGY RESEARCH. 1, 23-39
Zeise, Lauren, Bois, Frédéric Y, Chiu, Weihsueh A, Hattis, Dale, Rusyn, Ivan, Guyton, Kathryn Z (2012). Addressing human variability in next-generation human health risk assessments of environmental chemicals ENVIRONMENTAL HEALTH PERSPECTIVES. 1, 23-31
Reif, David M, Sypa, Myroslav, Lock, Eric F, Wright, Fred A, Wilson, Ander, Cathey, Tommy, Judson, Richard R, Rusyn, Ivan (2012). ToxPi GUI: an interactive visualization tool for transparent integration of data from diverse sources of evidence BIOINFORMATICS. 3, 402-403
Yin, M, Wheeler, M, Kono, H, Rusyn, I, Bradford, B, Gallucci, R, Luster, M, Goyert, S, Holland, S, Peters, J (2001). Role of Kupffer cells, endotoxin and tumor necrosis factor-alpha in alcohol-induced liver injury: studies with knockout mice CELLS OF THE HEPATIC SINUSOID. , 71-74
Uehara, Takeki, Ainslie, Garrett R, Kutanzi, Kristi, Pogribny, Igor P, Muskhelishvili, Levan, Izawa, Takeshi, Yamate, Jyoji, Kosyk, Oksana, Shymonyak, Svitlana, Bradford, Blair U (2013). Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis TOXICOLOGICAL SCIENCES. 1, 53-63
Uematsu, Fumiyuki, Takahashi, Masakazu, Yoshida, Midori, Maekawa, Akihiko, Rusyn, Ivan, Nakae, Dai (2004). Comprehensive expression analysis of hepatocellular carcinomas induced in rats fed a choline-deficient, l-amino acid-defined diet . ,
Rusyn, Ivan (2012). Mechanisms of Liver Carcinogenesis: Studies of Co-morbidity Factors Using Animal Models QSCIENCE PROCEEDINGS. 2012, 27
Wright, Fred A, Shabalin, Andrey A, Rusyn, Ivan (2012). Computational tools for discovery and interpretation of expression quantitative trait loci PHARMACOGENOMICS. 3, 343-352
Abdo, Nour, Wetmore, Barbara A, Chappell, Grace A, Shea, Damian, Wright, Fred A, Rusyn, Ivan (2015). In vitro screening for population variability in toxicity of pesticide-containing mixtures ENVIRONMENT INTERNATIONAL. , 147-155
Luo, Yu-Syuan, Furuya, Shinji, Chiu, Weihsueh, Rusyn, Ivan (2018). Characterization of inter-tissue and inter-strain variability of TCE glutathione conjugation metabolites DCVG, DCVC, and NAcDCVC in the mouse JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, PART A. 1-3, 37-52
Seniutkin, Oleksii, Furuya, Shinji, Luo, Yu-Syuan, Cichocki, Joseph A, Fukushima, Hisataka, Kato, Yuki, Sugimoto, Hiromi, Matsumoto, Tomoko, Uehara, Takeki, Rusyn, Ivan (2018). Effects of pirfenidone in acute and sub-chronic liver fibrosis, and an initiation-promotion cancer model in the mouse TOXICOLOGY AND APPLIED PHARMACOLOGY. , 1-9
Yang, Jialiang, Huang, Tao, Petralia, Francesca, Long, Quan, Zhang, Bin, Argmann, Carmen, Zhao, Yong, Mobbs, Charles V, Schadt, Eric E, Zhu, Jun (2016). Corrigendum: Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases SCIENTIFIC REPORTS. , 19384
Chiu, Weihsueh A, Rusyn, Ivan (2018). Advancing chemical risk assessment decision-making with population variability data: challenges and opportunities MAMMALIAN GENOME. 1-2, 182-189
Ketelslegers, Hans, Rusyn, Ivan, Kamelia, Lenny (2017). Using new methodologies for a better understanding of the health impacts of petroleum substances CONCAWE REVIEW. , 15-15
Venkatratnam, Abhishek, House, John S, Konganti, Kranti, McKenney, Connor, Threadgill, David W, Chiu, Weihsueh A, Aylor, David L, Wright, Fred A, Rusyn, Ivan (2018). Population-based dose–response analysis of liver transcriptional response to trichloroethylene in mouse MAMMALIAN GENOME. 1-2, 168-181
Harrill, Alison H, Ross, Pamela K, Gatti, Daniel M, Threadgill, David W, Rusyn, Ivan (2009). ToxSci Advance Access published May 6, 2009 . ,
Israel, Jennifer W, Chappell, Grace A, Simon, Jeremy M, Pott, Sebastian, Safi, Alexias, Lewis, Lauren, Cotney, Paul, Boulos, Hala S, Bodnar, Wanda, Lieb, Jason D (2018). Tissue-and strain-specific effects of a genotoxic carcinogen 1, 3-butadiene on chromatin and transcription MAMMALIAN GENOME. 1-2, 153-167
F Eduati et al (2015). Prediction of human population responses to toxic compounds by a collaborative competition NAT BIOTECHNOL. 9, 933-940
Rusyn, I, Rose, ML, Gonzelez, FJ, Thrman, RG (2000). Peroxisome proliferator-activated receptor beta is restricted to hepatic parenchymal cells, not kupffer cells; implicatiojns for the mechanism of action of peoxisome proliferators in hepatocarcinogenesis CARCINOGENESIS-OXFORD-. 4, 823-826
Low, Yen S, Caster, Ola, Bergvall, Tomas, Fourches, Denis, Zang, Xiaoling, Norén, G Niklas, Rusyn, Ivan, Edwards, Ralph, Tropsha, Alexander (2015). Cheminformatics-aided pharmacovigilance: application to Stevens-Johnson Syndrome JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION. 5, 968-978
Grimm, Fabian Alexander, Iwata, Yasuhiro, Sirenko, Oksana, Bittner, Michael, Rusyn, Ivan (2015). High-content assay multiplexing for toxicity screening in induced pluripotent stem cell-derived cardiomyocytes and hepatocytes ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES. 9, 529-546
Pogribny, Igor P, Beland, Frederick A, Rusyn, Ivan (2016). The role of microRNAs in the development and progression of chemical-associated cancers TOXICOLOGY AND APPLIED PHARMACOLOGY. , 3-10
Smith, Martyn T, Guyton, Kathryn Z, Gibbons, Catherine F, Fritz, Jason M, Portier, Christopher J, Rusyn, Ivan, DeMarini, David M, Caldwell, Jane C, Kavlock, Robert J, Lambert, Paul F (2015). Key characteristics of carcinogens as a basis for organizing data on mechanisms of carcinogenesis ENVIRONMENTAL HEALTH PERSPECTIVES. 6, 713-721
Chappell, Grace, Silva, Grace O, Uehara, Takeki, Pogribny, Igor P, Rusyn, Ivan (2016). Characterization of copy number alterations in a mouse model of fibrosis‐associated hepatocellular carcinoma reveals concordance with human disease CANCER MEDICINE. 3, 574-585
Rusyn, Ivan (2015). SYSTEMS BIOLOGY ANALYSIS OF GENETIC AND ENVIRONMENTAL DETERMINANTS OF TOXICITY DRUG METABOLISM REVIEWS. , 19-19
Rusyn, Ivan, Kono, Hiroshi, Kosyk, Oksana, Bradford, Blair U (2003). 522 Cytochrome P450 2E1, but not NADPH oxidase is required for ethanol-induced DNA damage and upregulation of DNA repair genes in mouse liver HEPATOLOGY. 38, 410
Uehara, Takeki, Kosyk, Oksana, Jeannot, Emmanuelle, Bradford, Blair U, Tech, Katherine, Macdonald, Jeffrey M, Boorman, Gary A, Chatterjee, Saurabh, Mason, Ronald P, Melnyk, Stepan B (2013). Acetaminophen-induced acute liver injury in HCV transgenic mice TOXICOLOGY AND APPLIED PHARMACOLOGY. 2, 224-232
Tryndyak, Volodymyr, de Conti, Aline, Kobets, Tetyana, Kutanzi, Kristy, Koturbash, Igor, Han, Tao, Fuscoe, James C, Latendresse, John R, Melnyk, Stepan, Shymonyak, Svitlana (2012). Interstrain differences in the severity of liver injury induced by a choline-and folate-deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism THE FASEB JOURNAL. 11, 4592-4602
Rusyn, Ivan (2001). In memoriam: Ronald G. thurman (1941–2001) . ,
Zhu, Hao, Ye, Lin, Richard, Ann, Golbraikh, Alexander, Wright, Fred A, Rusyn, Ivan, Tropsha, Alexander (2009). ALTERNATIVE MODEL DEVELOPMENT-A Novel Two-Step Hierarchical Quantitative Structure-Activity Relationship Modeling Work Flow for Predicting Acute Toxicity of Chemicals in Rodents ENVIRONMENTAL HEALTH PERSPECTIVES (ONLINE). 8, 1257
Kono, Hiroshi, Woods, Courtney G, Maki, Akira, Connor, Henry D, Mason, Ronald P, Rusyn, Ivan, Fujii, Hideki (2005). Electron spin resonance and spin trapping technique provide direct evidence that edaravone prevents acute ischemia# 8211reperfusion injury of the liver by limiting free radical-mediated tissue damage FREE RADICAL RESEARCH. 1, 1
Epe, Bernd, Ballmaier, Daniel, Roussyn, Ivan, Briviba, Karlis, Sies, Helmut (1996). DNA damage by peroxynitrite characterized with DNA repair enzymes NUCLEIC ACIDS RESEARCH. 21, 4105-4110
Roussyn, Ivan, Briviba, Karlis, Masumoto, Hiroshi, Sies, Helmut (1996). Selenium-containing compounds protect DNA from single-strand breaks caused by peroxynitrite ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 1, 216
BRIVIBA, Karlis, ROUSSYN, Ivan, SHAROV, Victor S, Helmut, SIES (1996). Attenuation of oxidation and nitration reactions of peroxynitrite by selenomethionine, selenocystine and ebselen BIOCHEMICAL JOURNAL. 1, 13-15
Portier, Christopher J, Armstrong, Bruce K, Baguley, Bruce C, Baur, Xaver, Belyaev, Igor, Bellé, Robert, Belpoggi, Fiorella, Biggeri, Annibale, Bosland, Maarten C, Bruzzi, Paolo (2016). Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA) J EPIDEMIOL COMMUNITY HEALTH. 8, 741-745
Rusyn, Ivan, Kleeberger, Steven R, McAllister, Kimberly A, French, John E, Svenson, Karen L (2018). Introduction to mammalian genome special issue: the combined role of genetics and environment relevant to human disease outcomes MAMMALIAN GENOME. 1-2, 1-4
Sirenko, Oksana, Crittenden, Carole, Callamaras, Nick, Hesley, Jayne, Chen, Yen-Wen, Funes, Carlos, Rusyn, Ivan, Anson, Blake, Cromwell, Evan F (2013). Multiparameter in vitro assessment of compound effects on cardiomyocyte physiology using iPSC cells JOURNAL OF BIOMOLECULAR SCREENING. 1, 39-53
Rusyn, Ivan, Bataller, Ramon (2013). Alcohol and toxicity JOURNAL OF HEPATOLOGY. 2, 387-388
Pogribny, Igor P, Kutanzi, Kristy, Melnyk, Stepan, de Conti, Aline, Tryndyak, Volodymyr, Montgomery, Beverly, Pogribna, Marta, Muskhelishvili, Levan, Latendresse, John R, James, S Jill (2013). Strain-dependent dysregulation of one-carbon metabolism in male mice is associated with choline-and folate-deficient diet-induced liver injury THE FASEB JOURNAL. 6, 2233-2243
Hu, Rong, Lam, Wen Jiun, Munday, Karen, Triggs, Christopher M, Zeisel, Steven H, Rahman, Irfan, Chung, Sangwoon, Starlard-Davenport, Athena, Tryndyak, Volodymyr, Kosyk, Oksana (2010). Author Index Vol 3, 2010 LIFESTYLE GENOMICS. 4-6, 315-315
Rusyn, Ivan (2000). Role of oxidants in molecular mechanism of action of peroxisome proliferators . ,
Hakenewerth, Anne M, Millikan, Robert C, Rusyn, Ivan, Herring, Amy H, Weissler, Mark C, Funkhouser, William K, North, Kari E, Barnholtz-Sloan, Jill S, Olshan, Andrew F (2013). Effects of polymorphisms in alcohol metabolism and oxidative stress genes on survival from head and neck cancer CANCER EPIDEMIOLOGY. 4, 479-491
Rusyn, Ivan, Bataller, Ramon (2013). Reply to:" The autophagic response to alcohol toxicity: the missing layer". JOURNAL OF HEPATOLOGY. 2, 399-400
Woods, C, Tak, W, Maki, A, Kadiiska, M, Connor, H, Mason, R, Cunningham, M, Rusyn, I (2004). the Role Of Hepatocyte And Kupffer Cell Derived Free Radicals In Peroxisome Proliferator Induced Carcinogenesis: 50 FREE RADICAL BIOLOGY AND MEDICINE. , S29-S30
Powell, CL, Craig, CP, Tsuchiya, M, Tak, WY, Threadgill, DW, Rusyn, I (2007). assessing the Role of Dna Methylation in the Susceptibility to Develop Alcohol-induced Liver Injury.: p39 ENVIRONMENTAL & MOLECULAR MUTAGENESIS. 7, 583
Rose, ML, Rusyn, I, Germolec, DR, Graves, LM, Peters, JM, Gonzalez, FJ, Thurman, RG (1998). Role of Kupffer cells and NF kappa B in peroxisome proliferator-induced cell proliferation. HEPATOLOGY. 4, 416A-416A
Hays, Thomas, Rusyn, Ivan, Burns, Amanda M, Kennett, Mary J, Ward, Jerrold M, Gonzalez, Frank J, Peters, Jeffrey M (2005). Role of peroxisome proliferator-activated receptor-α (PPARα) in bezafibrate-induced hepatocarcinogenesis and cholestasis CARCINOGENESIS. 1, 219-227
Rusyn, I (2011). Genetic Background-independent And-dependent Pathways In Alcohol-induced Liver Injury: 067 ALCOHOLISM: CLINICAL & EXPERIMENTAL RESEARCH. , 279A
Rusyn, Ivan, Tsukamoto, Hidekazu, Thurman, Ronald G (1998). WY-14 643 rapidly activates nuclear factor kappaB in Kupffer cells before hepatocytes. CARCINOGENESIS. 7, 1217-1222
Rusyn, Ivan, Peters, Jeffrey M, Cunningham, Michael L (2006). Modes of action and species-specific effects of di-(2-ethylhexyl) phthalate in the liver CRITICAL REVIEWS IN TOXICOLOGY. 5, 459-479
Rusyn, Ivan, Asakura, Shoji, Pachkowski, Brian, Bradford, Blair U, Denissenko, Mikhail F, Peters, Jeffrey M, Holland, Steven M, Reddy, Janardan K, Cunningham, Michael L, Swenberg, James A (2004). Expression of base excision DNA repair genes is a sensitive biomarker for in vivo detection of chemical-induced chronic oxidative stress: identification of the molecular source of radicals responsible for DNA damage by peroxisome proliferators CANCER RESEARCH. 3, 1050-1057
Wheeler, Michael D, Yamashina, Shunhei, Froh, Matthias, Rusyn, Ivan, Thurman, Ronald G (2001). Adenoviral gene delivery can inactivate Kupffer cells: role of oxidants in NF‐κB activation and cytokine production JOURNAL OF LEUKOCYTE BIOLOGY. 4, 622-630
Bradford, Blair U, Kono, Hiroshi, Isayama, Fuyumi, Kosyk, Oksana, Wheeler, Michael D, Akiyama, Taro E, Bleye, Lisa, Krausz, Kristopher W, Gonzalez, Frank J, Koop, Dennis R (2005). Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol‐induced oxidative DNA damage in rodent liver HEPATOLOGY. 2, 336-344
Yin, Ming, Ikejima, Kenichi, Arteel, Gavin E, Seabra, Vitor, Bradford, Blair U, Kono, Hiroshi, Rusyn, Ivan, Thurman, Ronald G (1998). Glycine accelerates recovery from alcohol-induced liver injury JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2, 1014-1019
Powell, Christine L, Swenberg, James A, Rusyn, Ivan (2005). Expression of base excision DNA repair genes as a biomarker of oxidative DNA damage CANCER LETTERS. 1, 1-11
Yin, Ming, Gäbele, Erwin, Wheeler, Michael D, Connor, Henry, Bradford, Blair U, Dikalova, Anna, Rusyn, Ivan, Mason, Ronald, Thurman, Ronald G (2001). Alcohol-induced free radicals in mice: direct toxicants or signaling molecules? HEPATOLOGY. 5, 935-942
Rose, Michelle L, Rusyn, Ivan, Bojes, Heidi K, Belyea, Jennifer, Cattley, Russell C, Thurman, Ronald G (2000). Role of Kupffer cells and oxidants in signaling peroxisome proliferator-induced hepatocyte proliferation MUTATION RESEARCH/FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 2, 179-192
Powell, Christine L, Kosyk, Oksana, Ross, Pamela K, Schoonhoven, Robert, Boysen, Gunnar, Swenberg, James A, Heinloth, Alexandra N, Boorman, Gary A, Cunningham, Michael L, Paules, Richard S (2006). Phenotypic anchoring of acetaminophen-induced oxidative stress with gene expression profiles in rat liver TOXICOLOGICAL SCIENCES. 1, 213-222
Kono, Hiroshi, Rusyn, Ivan, Bradford, Blair U, Connor, Henry D, Mason, Ronald P, Thurman, Ronald G (2000). Allopurinol prevents early alcohol-induced liver injury in rats JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 1, 296-303
Rusyn, Ivan, Kadiiska, Maria B, Dikalova, Anna, Kono, Hiroshi, Yin, Ming, Tsuchiya, Koichiro, Mason, Ronald P, Peters, Jeffrey M, Gonzalez, Frank J, Segal, Brahm H (2001). Phthalates rapidly increase production of reactive oxygen species in vivo: role of Kupffer cells MOLECULAR PHARMACOLOGY. 4, 744-750
Marvel, Skylar W, To, Kimberly, Grimm, Fabian A, Wright, Fred A, Rusyn, Ivan, Reif, David M (2018). ToxPi Graphical User Interface 2.0: Dynamic exploration, visualization, and sharing of integrated data models BMC BIOINFORMATICS. 1, 80
Guyton, Kathryn Z, Rusyn, Ivan, Chiu, Weihsueh A, Corpet, Denis E, van den Berg, Martin, Ross, Matthew K, Christiani, David C, Beland, Frederick A, Smith, Martyn T (2018). Application of the key characteristics of carcinogens in cancer hazard identification CARCINOGENESIS. 4, 614-622
Luo, Yu-Syuan, Furuya, Shinji, Soldatov, Valerie Y, Kosyk, Oksana, Yoo, Hong Sik, Fukushima, Hisataka, Lewis, Lauren, Iwata, Yasuhiro, Rusyn, Ivan (2018). Metabolism and toxicity of trichloroethylene and tetrachloroethylene in cytochrome P450 2E1 knockout and humanized transgenic mice TOXICOLOGICAL SCIENCES. 2, 489-500
Furuya, S, Cichocki, JA, Kono, H, Bataller, R, Rusyn, I (2018). Comprehensive analysis of alcohol treatment in mouse model of acute-on-chronic liver injury JOURNAL OF HEPATOLOGY. , S610
Caceres-Cortes, J, Reily, MD, Michael, A, Kuzyk, Smith, Derek, Yang, Juncong, Tyra, J, Cross‡, Angela, M, Darryl, B (2012). Flavonoid-mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, food-borne toxic compounds and bioactive ingredients DRUG METABOLISM REVIEWS. sup1, 36-152
Wignall, Jessica A, Muratov, Eugene, Sedykh, Alexander, Guyton, Kathryn Z, Tropsha, Alexander, Rusyn, Ivan, Chiu, Weihsueh A (2018). Conditional Toxicity Value (CTV) Predictor: An In Silico Approach for Generating Quantitative Risk Estimates for Chemicals ENVIRONMENTAL HEALTH PERSPECTIVES. 5, 057008
Dalaijamts, Chimeddulam, Cichocki, Joseph A, Luo, Yu-Syuan, Rusyn, Ivan, Chiu, Weihsueh A (2018). Incorporation of the glutathione conjugation pathway in an updated physiologically-based pharmacokinetic model for perchloroethylene in mice TOXICOLOGY AND APPLIED PHARMACOLOGY. , 142-152
Konganti, Kranti, Ehrlich, Andre, Rusyn, Ivan, Threadgill, David W (2018). gQTL: A Web Application for QTL Analysis Using the Collaborative Cross Mouse Genetic Reference Population G3: GENES, GENOMES, GENETICS. 8, 2559-2562
Grimm, Fabian, Rusyn, Ivan (2015). Advancing safety assessments of chemicals through biological read across using multidimensional in vitro toxicity testing ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. ,
Han, Jun, Danell, Ryan M, Patel, Jayanti R, Gumerov, Dmitry R, Scarlett, Cameron O, Speir, J Paul, Parker, Carol E, Rusyn, Ivan, Zeisel, Steven, Borchers, Christoph H (2008). Towards high-throughput metabolomics using ultrahigh-field Fourier transform ion cyclotron resonance mass spectrometry METABOLOMICS. 2, 128-140
Harrill, Alison H, Watkins, Paul B, Su, Stephen, Ross, Pamela K, Harbourt, David E, Stylianou, Ioannis M, Boorman, Gary A, Russo, Mark W, Sackler, Richard S, Harris, Stephen C (2009). Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans GENOME RESEARCH. 9, 1507-1515
Rusyn, Ivan, Rose, Michelle L, Bojes, Heidi K, Thurman, Ronald G (2000). Novel role of oxidants in the molecular mechanism of action of peroxisome proliferators ANTIOXIDANTS AND REDOX SIGNALING. 3, 607-621
Kono, Hiroshi, Nakagami, Mikio, Rusyn, Ivan, Connor, Henry D, Stefanovic, Branko, Brenner, David A, Mason, Ronald P, Arteel, Gavin E, Thurman, Ronald G (2001). Development of an animal model of chronic alcohol-induced pancreatitis in the rat AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. 6, G1178-G1186
Rusyn, Ivan, Denissenko, Mikhail F, Wong, Victoria A, Butterworth, Byron E, Cunningham, Michael L, Upton, Patricia B, Thurman, Ronald G, Swenberg, James A (2000). Expression of base excision repair enzymes in rat and mouse liver is induced by peroxisome proliferators and is dependent upon carcinogenic potency CARCINOGENESIS. 12, 2141-2145
Pogribny, Igor P, Tryndyak, Volodymyr P, Muskhelishvili, Levan, Rusyn, Ivan, Ross, Sharon A (2007). Methyl deficiency, alterations in global histone modifications, and carcinogenesis THE JOURNAL OF NUTRITION. 1, 216S-222S
Yin, Ming, Zhong, Zhi, Connor, Henry D, Bunzendahl, Hartwig, Finn, William F, Rusyn, Ivan, Li, Xiangli, Raleigh, James A, Mason, Ronald P, Thurman, Ronald G (2002). Protective effect of glycine on renal injury induced by ischemia-reperfusion in vivo AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 3, F417-F423
Wheeler, Michael D, Smutney, Olivia M, Check, Jennifer F, Rusyn, Ivan, Schulte-Hermann, R, Thurman, Ronald G (2003). Impaired Ras membrane association and activation in PPARα knockout mice after partial hepatectomy AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. 2, G302-G312
ROSE, MICHELLE L, RUSYN, IVAN, BOJES, HEIDI K, GERMOLEC, DORI R, LUSTER, MICHAEL, THURMAN, RONALD G (1999). Role of Kupffer cells in peroxisome proliferator-induced hepatocyte proliferation DRUG METABOLISM REVIEWS. 1, 87-116
Kono, Hiroshi, Uesugi, Takehiko, Froh, Matthias, Rusyn, Ivan, Bradford, Blair U, Thurman, Ronald G (2001). ICAM-1 is involved in the mechanism of alcohol-induced liver injury: studies with knockout mice AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. 6, G1289-G1295
Maki, Akira, Kono, Hiroshi, Gupta, Mayetri, Asakawa, Masami, Suzuki, Tetsuya, Matsuda, Masanori, Fujii, Hideki, Rusyn, Ivan (2007). Predictive power of biomarkers of oxidative stress and inflammation in patients with hepatitis C virus-associated hepatocellular carcinoma ANNALS OF SURGICAL ONCOLOGY. 3, 1182-1190
Hammond, LE, Albright, CD, He, LH, Rusyn, I, Watkins, SM, Lemasters, JJ, Coleman, RA (2005). Mitochondrial glycerol-3-phosphate acyltransferase 1 deficient mice have altered mitochondrial phospholipid fatty acid composition and mitochondrial dysfunction, and increased reactive oxygen species production, cell proliferation, and apoptosis FASEB JOURNAL. 4, A287-A287
Bradford, Blair U, Han, Jun, Kosyk, Oksana, Shymonyak, Svitlana, Winnike, Jason, Kono, Hiroshi, O'Connell, Thomas M, Rusyn, Ivan (2007). Metabolomic analysis of urine and liver after chronic alcohol treatment in C57BL/6J mice HEPATOLOGY. 4, 811A-811A
Swenberg, J, Jeong, YC, Liao, S, Baskerville, I, Nakamura, J, Ham, A, Morinello, E, Rusyn, I (2004). Oxidative DNA damage: New approaches to a very old problem. CHEMICAL RESEARCH IN TOXICOLOGY. 12, 1761-1761
Rusyn, Ivan, Lee, Myun H, Tak, Won Y, Milton, Richard J, Bradford, Blair U, Maki, Akira, Marron, Stephen J, Threadgill, David J (2006). Susceptibility To Alcohol-induced Liver Injury Is Independent Of Changes In Metabolism And Inflammation Pathways: 807 ALCOHOLISM: CLINICAL & EXPERIMENTAL RESEARCH. 9, 154A
Maki, A, Kono, H, Asakawa, M, Matsuda, M, Fujii, H, Rusyn, I (2004). Predictive power of oxidative stress biomarkers in patients with HCV-associated hepatocellular carcinoma FREE RADICAL BIOLOGY AND MEDICINE. , S136-S136
Jeannot, Emmanuelle, Boorman, Gary A, Shymonyak, Svitlana, Kosyk, Oksana, Rusyn, Ivan (2009). Incidence of aflatoxin B1-induced hepatic tumors is increased in Hepatitis Virus C transgenic mice as compared to wild type C57BL/6J strain HEPATOLOGY. 4, 1141A-1141A
Formeister, Eric J, Tsuchiya, Masato, Pogribny, Igor, Rusyn, Ivan (2009). Methylation Frequency Of P16, Socs-1, Rassf1a, Apc And Gstp1 Promoters In Tumorous, Non-tumorous And Metastatic Liver Tumor Samples From Hcv-positive Patients With Hcc In Japan: 1769 HEPATOLOGY. , 1122A
Yeatts, KB, Olshan, AF, El-Sadig, M, Funk, WE, Leith, D, Ng, S, Zoubedi, T, Al-Maskari, F, Chan, R, Couper, D (2011). INDOOR AIR EXPOSURES AND HEALTH IN THE UNITED ARAB EMIRATES (UAE). AMERICAN JOURNAL OF EPIDEMIOLOGY. , S257-S257
Rusyn, I, Asakura, S, Denissenko, M, Thurman, R, Samson, L, Swenberg, J (2001). Peroxicome proliferators cause induction of long-patch base excision DNA repair pathway in vivo FREE RADICAL BIOLOGY AND MEDICINE. , S141-S141
Chappell, Grace, Pogribny, Igor P, Guyton, Kathryn Z, Rusyn, Ivan (2016). Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: a systematic literature review MUTATION RESEARCH/REVIEWS IN MUTATION RESEARCH. , 27-45
Zavala, Jose, O’Brien, Bridget, Lichtveld, Kim, Sexton, Kenneth G, Rusyn, Ivan, Jaspers, Ilona, Vizuete, William (2016). Assessment of biological responses of EpiAirway 3-D cell constructs versus A549 cells for determining toxicity of ambient air pollution INHALATION TOXICOLOGY. 6, 251-259
Cote, Ila, Andersen, Melvin E, Ankley, Gerald T, Barone, Stanley, Birnbaum, Linda S, Boekelheide, Kim, Bois, Frederic Y, Burgoon, Lyle D, Chiu, Weihsueh A, Crawford-Brown, Douglas (2016). The Next Generation of Risk Assessment multi-year study—highlights of findings, applications to risk assessment, and future directions ENVIRONMENTAL HEALTH PERSPECTIVES. 11, 1671-1682
Allen, Naomi, Anderson, Lucy M, Beland, Frederick A, Bénichou, Jacques, Beral, Valerie, Bloomfield, Kim, Brooks, Philip J, Cai, Lin, Cho, Sung Il, Crabb, David W (2010). Alcohol consumption and ethyl carbamate IARC MONOGRAPHS ON THE EVALUATION OF CARCINOGENIC RISKS TO HUMANS. , 1-1379
Grimm, Fabian A, Iwata, Yasuhiro, Sirenko, Oksana, Chappell, Grace A, Wright, Fred A, Reif, David M, Braisted, John, Gerhold, David L, Yeakley, Joanne M, Shepard, Peter (2016). A chemical–biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives GREEN CHEMISTRY. 16, 4407-4419
Knap, Anthony H, Rusyn, Ivan (2016). Environmental exposures due to natural disasters REVIEWS ON ENVIRONMENTAL HEALTH. 1, 89-92
Guyton, Kathryn Z, Loomis, Dana, Grosse, Yann, El Ghissassi, Fatiha, Benbrahim-Tallaa, Lamia, Guha, Neela, Scoccianti, Chiara, Mattock, Heidi, Straif, Kurt (2015). Carcinogenicity of tetrachlorvinphos, parathion, malathion, diazinon, and glyphosate THE LANCET ONCOLOGY. 5, 490-491
Rusyn, Ivan, Yamashina, Shunhei, Segal, Brahm H, Schoonhoven, Robert, Holland, Steven M, Cattley, Russell C, Swenberg, James A, Thurman, Ronald G (2000). Oxidants from nicotinamide adenine dinucleotide phosphate oxidase are involved in triggering cell proliferation in the liver due to peroxisome proliferators CANCER RESEARCH. 17, 4798-4803
Arteel, Gavin E, Kadiiska, Maria B, Rusyn, Ivan, Bradford, Blair U, Mason, Ronald P, Raleigh, James A, Thurman, Ronald G (1999). Oxidative stress occurs in perfused rat liver at low oxygen tension by mechanisms involving peroxynitrite MOLECULAR PHARMACOLOGY. 4, 708-715
Beyer, Richard P, Fry, Rebecca C, Lasarev, Michael R, McConnachie, Lisa A, Meira, Lisiane B, Palmer, Valerie S, Powell, Christine L, Ross, Pamela K, Bammler, Theo K, Bradford, Blair U (2007). Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses TOXICOLOGICAL SCIENCES. 1, 326-337
Kono, Hiroshi, Fujii, Hideki, Asakawa, Masami, Yamamoto, Masayuki, Maki, Akira, Matsuda, Masanori, Rusyn, Ivan, Matsumoto, Yoshiro (2002). Functional heterogeneity of the kupffer cell population is involved in the mechanism of gadolinium chloride in rats administered endotoxin JOURNAL OF SURGICAL RESEARCH. 1, 179-187
Roberts, Adam, McMillan, Leonard, Wang, Wei, Parker, Joel, Rusyn, Ivan, Threadgill, David (2007). Inferring missing genotypes in large SNP panels using fast nearest-neighbor searches over sliding windows BIOINFORMATICS. 13, i401-i407
Yamashina, Shunhei, Konno, Akira, Wheeler, Michael D, Rusyn, Ivan, Rusyn, Elena V, Cox, Adrienne D, Thurman, Ronald G (2001). Endothelial cells contain a glycine-gated chloride channel NUTRITION AND CANCER. 2, 197-204
Yamashina, Shunhei, Wheeler, Michael D, Rusyn, Ivan, Ikejima, Kenichi, Sato, Nobuhiro, Thurman, Ronald G (2000). Tolerance and sensitization to endotoxin in Kupffer cells caused by acute ethanol involve interleukin-1 receptor-associated kinase BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 3, 686-690
Gatti, Daniel, Maki, Akira, Chesler, Elissa J, Kirova, Roumyana, Kosyk, Oksana, Lu, Lu, Manly, Kenneth F, Williams, Robert W, Perkins, Andy, Langston, Michael A (2007). Genome‐level analysis of genetic regulation of liver gene expression networks HEPATOLOGY. 2, 548-557
Harrill, Alison Hege, Rusyn, Ivan (2008). Systems biology and functional genomics approaches for the identification of cellular responses to drug toxicity EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. 11, 1379-1389
Rusyn, Ivan, Bradham, Cynthia A, Cohn, Leslie, Schoonhoven, Robert, Swenberg, James A, Brenner, David A, Thurman, Ronald G (1999). Corn oil rapidly activates nuclear factor-κB in hepatic Kupffer cells by oxidant-dependent mechanisms CARCINOGENESIS. 11, 2095-2100
Wheeler, MD, Smutney, OM, Check, JF, Rusyn, I, Schulte-Hermann, R, Thurman, RG (2003). Impaired Ras membrane association and activation in PPAR alpha knockout mice after partial hepatectomy (vol 284, pg G302, 2003) AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. 3, GA2-GA2
Cichocki, Joseph A, Guyton, Kathryn Z, Guha, Neela, Chiu, Weihsueh A, Rusyn, Ivan, Lash, Lawrence H (2016). Target organ metabolism, toxicity, and mechanisms of trichloroethylene and perchloroethylene: key similarities, differences, and data gaps JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 1, 110-123
Zhu, Hao, Rusyn, Ivan, Richard, Ann, Tropsha, Alexander (2008). COMPUTATIONAL BIOLOGY-Use of Cell Viability Assay Data Improves the Prediction Accuracy of Conventional Quantitative Structure-Activity Relationship Models of Animal Carcinogenicity ENVIRONMENTAL HEALTH PERSPECTIVES (ONLINE). 4, 506
Furuya, S, Iwata, Y, Chappell, G, Bataller, R, Rusyn, I (2016). Transcriptomic analysis of a novel mouse model of fibrosis-and alcohol-associated acute kidney injury (AKI) reveals key deregulated pathways ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH. , 195A-195A
RUSYN, Ivan (2014). Toxicogenomics and toxicogenetics: Genetic diversity and susceptibility to toxicity in next-generation human health risk assessment 日本毒性学会学術年会 第 41 回日本毒性学会学術年会. , EL4
Furuya, Shinji, Chappell, Grace A, Iwata, Yasuhiro, Uehara, Takeki, Kato, Yuki, Kono, Hiroshi, Bataller, Ramon, Rusyn, Ivan (2016). A mouse model of alcoholic liver fibrosis-associated acute kidney injury identifies key molecular pathways TOXICOLOGY AND APPLIED PHARMACOLOGY. , 129-139
Roy, Monique S, Carl, James R (1987). Institution of Insulin Therapy Reverses Retinal Vascular Leakage: A Case Report DIABETES CARE. 5, 660-662
Tryndyak, V, Jeannot, E, Rusyn, I, Pogribny, I (2010). microrna Expression during Aflatoxin B1-induced Hepatocarcinogenesis in Hcv Transgenic and C57bl/6j Mice.: s30 ENVIRONMENTAL & MOLECULAR MUTAGENESIS. 7, 692
Scherhag, A, Sorrentino, J, Pogribny, I, Rusyn, I, Koturbash, I (2010). epigenetic Changes in C57bl/6j Mice Induced by Short-term Exposure to 1, 3-butadiene by Inhalation.: s31 ENVIRONMENTAL & MOLECULAR MUTAGENESIS. 7, 693
Zhu, Hao, Sedykh, Alexander, Wright, Fred, Rusyn, Ivan, Tropsha, Alexander (2009). Using quantitative high-throughput screening (qHTS) results as biological descriptors to assist quantitative structure activity relationship (QSAR) modeling of rat acute toxicity ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. ,
Zhu, Hao, Rusyn, Ivan, Richard, Ann, Tropsha, Alexander (2008). Use of cell viability assay data improves the prediction accuracy of conventional quantitative structure–activity relationship models of animal carcinogenicity ENVIRONMENTAL HEALTH PERSPECTIVES. 4, 506-513
Kono, Hiroshi, Bradford, Blair U, Rusyn, Ivan, Fujii, Hideki, Matsumoto, Yoshiro, Yin, Ming, Thurman, Ronald G (2000). Development of an intragastric enteral model in the mouse: studies of alcohol-induced liver disease using knockout technology JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY. 4, 395-400
Pogribny, Igor P, Tryndyak, Volodymyr P, Boureiko, Anna, Melnyk, Stepan, Bagnyukova, Tetyana V, Montgomery, Beverly, Rusyn, Ivan (2008). Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver MUTATION RESEARCH/FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 1-2, 17-23
Pogribny, Igor P, Rusyn, Ivan, Beland, Frederick A (2008). Epigenetic aspects of genotoxic and non‐genotoxic hepatocarcinogenesis: Studies in rodents ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 1, 9-15
Wheeler, Michael D, Kono, Hiroshi, Rusyn, Ivan, Arteel, Gavin E, McCarty, Douglas, Samulski, Richard Jude, Thurman, Ronald G (2000). Chronic ethanol increases adeno-associated viral transgene expression in rat liver via oxidant and NFκB-dependent mechanisms HEPATOLOGY. 5, 1050-1059
Harrill, Alison H, Ross, Pamela K, Gatti, Daniel M, Threadgill, David W, Rusyn, Ivan (2009). Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel TOXICOLOGICAL SCIENCES. 1, 235-243
Bradford, Blair U, O'connell, Thomas M, Han, Jun, Kosyk, Oksana, Shymonyak, Svitlana, Ross, Pamela K, Winnike, Jason, Kono, Hiroshi, Rusyn, Ivan (2008). Metabolomic profiling of a modified alcohol liquid diet model for liver injury in the mouse uncovers new markers of disease TOXICOLOGY AND APPLIED PHARMACOLOGY. 2, 236-243
Pogribny, Igor P, Starlard-Davenport, Athena, Tryndyak, Volodymyr P, Han, Tao, Ross, Sharon A, Rusyn, Ivan, Beland, Frederick A (2010). Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice LABORATORY INVESTIGATION. 10, 1437
Pogribny, Igor P, Tryndyak, Volodymyr P, Bagnyukova, Tetyana V, Melnyk, Stepan, Montgomery, Beverly, Ross, Sharon A, Latendresse, John R, Rusyn, Ivan, Beland, Frederick A (2009). Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet JOURNAL OF HEPATOLOGY. 1, 176-186
Bradford, B, Kosyk, O, Rusyn, I (2004). The effect of DNA damaging agents on gene expression of DNA repair glycosylases in human and mouse fibroblasts FREE RADICAL BIOLOGY AND MEDICINE. , S169-S169
Li, Gen, Shabalin, Andrey A, Rusyn, Ivan, Wright, Fred A, Nobel, Andrew B (2016). An empirical Bayes approach for multiple tissue eQTL analysis ARXIV PREPRINT ARXIV:1311.2948V4. ,
Rusyn, I (2008). Experimental pharmacogenetic approaches to understanding toxic responses in populations ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 7, 519-519
Rusyn, I (2008). Mechanisms Of Alcohol-related Liver Carcinogenesis: 273 ALCOHOLISM: CLINICAL & EXPERIMENTAL RESEARCH. 6, 341A
Tang, Hao, Zhu, Hao, Zhang, Liying, Sedykh, Alexander, Richard, Ann, Rusyn, Ivan, Tropsha, Alexander (2010). Toxicity reference database (ToxRefDB) to develop predictive toxicity models and prioritize compounds for future toxicity testing ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. ,
Combs, Terry P, Bryan, Rachael P, Asmar, Melissa M, Alderman, J McKee, Alderman, Elizabeth A, Garland, Alaina L, Busby, Walker H, Bodnar, Wanda M, Rusyn, Ivan, Medoff, Benjamin D (2010). Intracellular Expression of TOA Lowers Glucose Production DIABETES. , A415-A415
Rusyn, I (2010). Computational Toxicology: From Data to Analyses to Applications BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY. 5, 344-344
Wang, Kun, Richard, Ann, Rusyn, Ivan, Tropsha, Alexander (2007). Toxico-cheminformatics and QSPR modeling of the carcinogenic potency database CHEMICAL RESEARCH IN TOXICOLOGY. 12, 2013-2013
Powell, C, Kosyk, O, Bradford, B, Denda, A, Konishi, Y, Uematsu, F, Nakae, D, Rusyn, I (2004). temporal Correlation Of Histopathological Changes And Markers Of Oxidative Dna Damage With Gene Expression In A Choline Deficient Model Of Hepatocellular Carcinoma: 512 FREE RADICAL BIOLOGY AND MEDICINE. , S174
Tsuchiya, Masato, Parker, Joel S, Kono, Hiroshi, Matsuda, Masanori, Fujii, Hideki, Rusyn, Ivan (2009). Gene Expression In Non-tumoral Liver Tissue And Risk Of Recurrence Of Hepatocellular Carcinoma In Hepatitis C Virus-positive Subjects: 1825 HEPATOLOGY. , 1147A
Yeatts, KB, Olshan, AF, Funk, WE, El-Sadig, M, Al-Maskari, F, Chan, RL, Popkin, B, Ng, SW, Rusyn, I, MacDonald, J (2010). The United Arab Emirates (UAE) Indoor Air, Health, and Nutrition Study AMERICAN JOURNAL OF EPIDEMIOLOGY. , S80-S80
Zhang, Liying, Sedykh, Alexander, Tripathi, Ashutosh, Zhu, Hao, Afantitis, Antreas, Mouchlis, Varnavas D, Melagraki, Georgia, Rusyn, Ivan, Tropsha, Alexander (2013). Identification of putative estrogen receptor-mediated endocrine disrupting chemicals using QSAR-and structure-based virtual screening approaches TOXICOLOGY AND APPLIED PHARMACOLOGY. 1, 67-76
Leaver-Fay, Andrew, Snoeyink, Jack, Kuhlman, Brian (2008). On-the-fly rotamer pair energy evaluation in protein design INTERNATIONAL SYMPOSIUM ON BIOINFORMATICS RESEARCH AND APPLICATIONS. , 343-354
Rusyn, I (2016). A Chemical-Biological Similarity-Based Grouping of Complex Substances Using Multi-Dimensional High-Content Screening of Human-Induced Pluripotent Stem Cell (iPSC)-Derived Models. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. , S43-S43
Cichocki, Joseph A, Furuya, Shinji, Luo, Yu S, Sweet, Stephen, Wade, Terry, Knap, Anthony, McDonald, Thomas J, threadgill, david, Chiu, Weihsueh, Rusyn, Ivan (2016). Xenobiotic metabolism in a mouse model of non-alcoholic fatty liver disease: A case study of the ubiquitous environmental contaminant tetrachloroethylene HEPATOLOGY. 1 SUPP, 800A-800A
Chiu, Weihsueh A, Wright, Fred A, Rusyn, Ivan (2017). A tiered, Bayesian approach to estimating of population variability for regulatory decision-making ALTEX. 3, 377
Swenberg, James A, Georgieva, Nadia, Ham, Amy, Koc, Hasan, Morinello, Eric, Nakamura, Jun, Ranasinghe, Asoka, Rios-Blanco, Melva, Rusyn, Ivan, Upton, Patricia (2000). biomarkers of Exposure and Effect TOXICOLOGIC PATHOLOGY. 6, 875-876
Ibrahim, Yehia M, Garimella, Sandilya VB, Prost, Spencer A, Wojcik, Roza, Norheim, Randolph V, Baker, Erin S, Rusyn, Ivan, Smith, Richard D (2016). Development of an ion mobility spectrometry-orbitrap mass spectrometer platform ANALYTICAL CHEMISTRY. 24, 12152-12160
Cichocki, Joseph A, Furuya, Shinji, Konganti, Kranti, Luo, Yu-Syuan, McDonald, Thomas J, Iwata, Yasuhiro, Chiu, Weihsueh A, Threadgill, David W, Pogribny, Igor P, Rusyn, Ivan (2017). Impact of nonalcoholic fatty liver disease on toxicokinetics of tetrachloroethylene in mice JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 1, 17-28
Smith, Martyn T, Guyton, Kathryn Z, Gibbons, Catherine F, Fritz, Jason M, Portier, Christopher J, Rusyn, Ivan, DeMarini, David M, Caldwell, Jane C, Kavlock, Robert J (2016). 発がん物質の鍵となる特性発がんメカニズムの根拠となるデータの統合 ENVIRON HEALTH PERSPECT. 6,
Sirenko, Oksana, Grimm, Fabian A, Ryan, Kristen R, Iwata, Yasuhiro, Chiu, Weihsueh A, Parham, Frederick, Wignall, Jessica A, Anson, Blake, Cromwell, Evan F, Behl, Mamta (2017). In vitro cardiotoxicity assessment of environmental chemicals using an organotypic human induced pluripotent stem cell-derived model TOXICOLOGY AND APPLIED PHARMACOLOGY. , 60-74
Dreval, Kostiantyn, de Conti, Aline, Furuya, Shinji, Beland, Frederick A, Rusyn, Ivan, Pogribny, Igor P (2017). miR-1247 blocks SOX9–mediated regeneration in alcohol-and fibrosis-associated acute kidney injury in mice TOXICOLOGY. , 40-49
Kono, Hiroshi, Rusyn, Ivan, Yin, Ming, Gäbele, Erwin, Yamashina, Shunhei, Dikalova, Anna, Kadiiska, Maria B, Connor, Henry D, Mason, Ronald P, Segal, Brahm H (2000). NADPH oxidase–derived free radicals are key oxidants in alcohol-induced liver disease THE JOURNAL OF CLINICAL INVESTIGATION. 7, 867-872
Wheeler, Michael D, Kono, Hiroshi, Yin, Ming, Nakagami, Mikio, Uesugi, Takehiko, Arteel, Gavin E, Gäbele, Erwin, Rusyn, Ivan, Yamashina, Shunhei, Froh, Matthias (2001). The role of Kupffer cell oxidant production in early ethanol-induced liver disease FREE RADICAL BIOLOGY AND MEDICINE. 12, 1544-1549
Stachlewitz, Robert F, Seabra, Vitor, Bradford, Blair, Bradham, Cynthia A, Rusyn, Ivan, Germolec, Dori, Thurman, Ronald G (1999). Glycine and uridine prevent d‐galactosamine hepatotoxicity in the rat: Role of kupffer cells HEPATOLOGY. 3, 737-745
Roberts, Ruth A, Ganey, Patricia E, Ju, Cynthia, Kamendulis, Lisa M, Rusyn, Ivan, Klaunig, James E (2006). Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis TOXICOLOGICAL SCIENCES. 1, 2-15
Kono, Hiroshi, Rusyn, Ivan, Uesugi, Takehiko, Yamashina, Shunhei, Connor, Henry D, Dikalova, Anna, Mason, Ronald P, Thurman, Ronald G (2001). Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. 5, G1005-G1012
Wheeler, MD, Ikejema, K, Enomoto, N, Stacklewitz, RF, Seabra, V, Zhong, Z, Yin, M, Schemmer, P, Rose, ML, Rusyn, I (1999). Glycine: a new anti-inflammatory immunonutrient CELLULAR AND MOLECULAR LIFE SCIENCES CMLS. 9-10, 843-856
Kono, Hiroshi, Wheeler, Michael D, Rusyn, Ivan, Lin, Min, Seabra, Vitor, Rivera, Chantal A, Bradford, Blair U, Forman, Donald T, Thurman, Ronald G (2000). Gender differences in early alcohol-induced liver injury: role of CD14, NF-κB, and TNF-α AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. 4, G652-G661
Peters, Jeffrey M, Rusyn, Ivan, Rose, Michelle L, Gonzalez, Frank J, Thurman, Ronald G (2000). Peroxisome proliferator-activated receptor α is restricted to hepatic parenchymal cells, not Kupffer cells: implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis CARCINOGENESIS. 4, 823-826
Wheeler, Michael D, Nakagami, Mikio, Bradford, Blair U, Uesugi, Takehiko, Mason, Ronald P, Connor, Henry D, Dikalova, Anna, Kadiiska, Maria, Thurman, Ronald G (2001). Overexpression of manganese superoxide dismutase prevents alcohol-induced liver injury in the rat JOURNAL OF BIOLOGICAL CHEMISTRY. 39, 36664-36672
Kono, Hiroshi, Arteel, Gavin E, Rusyn, Ivan, Sies, Helmut, Thurman, Ronald G (2001). Ebselen prevents early alcohol-induced liver injury in rats FREE RADICAL BIOLOGY AND MEDICINE. 4, 403-411
Iimuro, Yuji, Bradford, Blair U, Yamashina, Shunhei, Rusyn, Ivan, Nakagami, Mikio, Enomoto, Nobuyuki, Kono, Hiroshi, Frey, William, Forman, Donald, Brenner, David (2000). The glutathione precursor L‐2‐oxothiazolidine‐4‐carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat HEPATOLOGY. 2, 391-398
Venkatratnam, Abhishek, Furuya, Shinji, Kosyk, Oksana, Gold, Avram, Bodnar, Wanda, Konganti, Kranti, Threadgill, David W, Gillespie, Kevin M, Aylor, David L, Wright, Fred A (2017). Editor’s highlight: collaborative cross mouse population enables refinements to characterization of the variability in toxicokinetics of trichloroethylene and provides genetic evidence for the role of PPAR pathway in its oxidative metabolism TOXICOLOGICAL SCIENCES. 1, 48-62
Li, Gen, Shabalin, Andrey A, Rusyn, Ivan, Wright, Fred A, Nobel, Andrew B (2017). An empirical Bayes approach for multiple tissue eQTL analysis BIOSTATISTICS. 3, 391-406
Chappell, Grace A, Israel, Jennifer W, Simon, Jeremy M, Pott, Sebastian, Safi, Alexias, Eklund, Karl, Sexton, Kenneth G, Bodnar, Wanda, Lieb, Jason D, Crawford, Gregory E (2017). Variation in DNA-damage responses to an inhalational carcinogen (1, 3-butadiene) in relation to strain-specific differences in chromatin accessibility and gene transcription profiles in C57BL/6J and CAST/EiJ mice ENVIRONMENTAL HEALTH PERSPECTIVES. 10, 107006
Onel, Melis, Beykal, Burcu, Wang, Meichen, Grimm, Fabian A, Zhou, Lan, Wright, Fred A, Phillips, Timothy D, Rusyn, Ivan, Pistikopoulos, Efstratios N (2018). Optimal Chemical Grouping and Sorbent Material Design by Data Analysis, Modeling and Dimensionality Reduction Techniques COMPUTER AIDED CHEMICAL ENGINEERING. , 421-426
Grimm, Fabian A, Blanchette, Alexander, House, John S, Ferguson, Kyle, Hsieh, Nan-Hung, Dalaijamts, Chimeddulam, Wright, Alec A, Anson, Blake, Wright, Fred A, Chiu, Weihsueh A (2018). A human population-based organotypic in vitro model for cardiotoxicity screening ALTEX. 4, 441
Luo, Yu-Syuan, Hsieh, Nan-Hung, Soldatow, Valerie Y, Chiu, Weihsueh A, Rusyn, Ivan (2018). Comparative analysis of metabolism of trichloroethylene and tetrachloroethylene among mouse tissues and strains TOXICOLOGY. , 33-43
Guyton, Kathryn Z, Rusyn, Ivan, Chiu, Weihsueh A, Corpet, Denis E, van den Berg, Martin, Ross, Matthew K, Christiani, David C, Beland, Frederick A, Smith, Martyn T (2018). Re:‘Application of the key characteristics of carcinogens in cancer hazard evaluation’: response to Goodman, Lynch and Rhomberg CARCINOGENESIS. 8, 1091-1093
Klaren, William D, Rusyn, Ivan (2018). High-content assay multiplexing for muscle toxicity screening in human-induced pluripotent stem cell-derived skeletal myoblasts ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES. 6, 333-342
Feng, SS (2004). Editorial Board Members EXPERT REVIEW OF MEDICAL DEVICES. 1, 115-125
Tsuchiya, Masato, Kono, Hiroshi, Matsuda, Masanori, Fujii, Hideki, Rusyn, Ivan (2008). Protective effect of Juzen‐taiho‐to on hepatocarcinogenesis is mediated through the inhibition of Kupffer cell‐induced oxidative stress INTERNATIONAL JOURNAL OF CANCER. 11, 2503-2511
Rusyn, Ivan, Asakura, Shoji, Li, Yutai, Kosyk, Oksana, Koc, Hasan, Nakamura, Jun, Upton, Patricia B, Swenberg, James A (2005). Effects of ethylene oxide and ethylene inhalation on DNA adducts, apurinic/apyrimidinic sites and expression of base excision DNA repair genes in rat brain, spleen, and liver DNA REPAIR. 10, 1099-1110
Bradford, Blair U, Rusyn, Ivan (2005). Swift increase in alcohol metabolism (SIAM): understanding the phenomenon of hypermetabolism in liver ALCOHOL. 1, 13-17
Pogribny, Igor P, Tryndyak, Volodymyr P, Woods, Courtney G, Witt, Sarah E, Rusyn, Ivan (2007). Epigenetic effects of the continuous exposure to peroxisome proliferator WY-14,643 in mouse liver are dependent upon peroxisome proliferator activated receptor α MUTATION RESEARCH/FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 1-2, 62-71
Woods, Courtney G, Vanden Heuvel, John P, Rusyn, Ivan (2007). Genomic profiling in nuclear receptor-mediated toxicity TOXICOLOGIC PATHOLOGY. 4, 474-494
Peffer, Richard C, Moggs, Jonathan G, Pastoor, Timothy, Currie, Richard A, Wright, Jayne, Milburn, Gill, Waechter, Felix, Rusyn, Ivan (2007). Mouse liver effects of cyproconazole, a triazole fungicide: role of the constitutive androstane receptor TOXICOLOGICAL SCIENCES. 1, 315-325
Woods, Courtney G, Burns, Amanda M, Bradford, Blair U, Ross, Pamela K, Kosyk, Oksana, Swenberg, James A, Cunningham, Michael L, Rusyn, Ivan (2007). WY-14,643–Induced Cell Proliferation and Oxidative Stress in Mouse Liver are Independent of NADPH Oxidase TOXICOLOGICAL SCIENCES. 2, 366-374
Gatti, Daniel M, Barry, William T, Nobel, Andrew B, Rusyn, Ivan, Wright, Fred A (2010). Heading down the wrong pathway: on the influence of correlation within gene sets BMC GENOMICS. 1, 574
Powell, Christine L, Kosyk, Oksana, Bradford, Blair U, Parker, Joel S, Lobenhofer, Edward K, Denda, Ayumi, Uematsu, Fumiyuki, Nakae, Dai, Rusyn, Ivan (2005). Temporal correlation of pathology and DNA damage with gene expression in a choline‐deficient model of rat liver injury HEPATOLOGY. 5, 1137-1147
Tsuchiya, Masato, Parker, Joel S, Kono, Hiroshi, Matsuda, Masanori, Fujii, Hideki, Rusyn, Ivan (2010). Gene expression in nontumoral liver tissue and recurrence-free survival in hepatitis C virus-positive hepatocellular carcinoma MOLECULAR CANCER. 1, 74
Xu, Shiyao, Zhu, Bao Ting, Turan, Valerie, Rusyn, Ivan, Thurman, Ronald, Peters, Jeffrey M, Gonzalez, Frank J, Conney, Allan H (2001). PPARα-dependent induction of liver microsomal esterification of estradiol and testosterone by a prototypical peroxisome proliferator ENDOCRINOLOGY. 8, 3554-3557
Rusyn, Ivan, Daston, George P (2010). Computational toxicology: realizing the promise of the toxicity testing in the 21st century ENVIRONMENTAL HEALTH PERSPECTIVES. 8, 1047-1050
Grimm, Fabian A, Russell, William K, Luo, Yu-Syuan, Iwata, Yasuhiro, Chiu, Weihsueh A, Roy, Tim, Boogaard, Peter J, Ketelslegers, Hans B, Rusyn, Ivan (2017). Grouping of petroleum substances as example UVCBs by ion mobility-mass spectrometry to enable chemical composition-based read-across ENVIRONMENTAL SCIENCE & TECHNOLOGY. 12, 7197-7207
Cichocki, Joseph A, Furuya, Shinji, Venkatratnam, Abhishek, McDonald, Thomas J, Knap, Anthony H, Wade, Terry, Sweet, Stephen, Chiu, Weihsueh A, Threadgill, David W, Rusyn, Ivan (2017). Characterization of variability in toxicokinetics and toxicodynamics of tetrachloroethylene using the collaborative cross mouse population ENVIRONMENTAL HEALTH PERSPECTIVES. 5, 057006
Cichocki, Joseph A, Furuya, Shinji, Luo, Yu-Syuan, Iwata, Yasuhiro, Konganti, Kranti, Chiu, Weihsueh A, Threadgill, David W, Pogribny, Igor P, Rusyn, Ivan (2017). Nonalcoholic fatty liver disease is a susceptibility factor for perchloroethylene-induced liver effects in mice TOXICOLOGICAL SCIENCES. 1, 102-113
Hu, Rong, Lam, Wen Jiun, Munday, Karen, Triggs, Christopher M, Zeisel, Steven H, Rahman, Irfan, Chung, Sangwoon, Starlard-Davenport, Athena, Tryndyak, Volodymyr, Kosyk, Oksana (2010). ISNN Membership Application Form LIFESTYLE GENOMICS. 4-6, 313-313
Hu, Rong, Lam, Wen Jiun, Munday, Karen, Triggs, Christopher M, Zeisel, Steven H, Rahman, Irfan, Chung, Sangwoon, Starlard-Davenport, Athena, Tryndyak, Volodymyr, Kosyk, Oksana (2010). Subject Index Vol 3, 2010 LIFESTYLE GENOMICS. 4-6, 316-316
Hu, Rong, Lam, Wen Jiun, Munday, Karen, Triggs, Christopher M, Zeisel, Steven H, Rahman, Irfan, Chung, Sangwoon, Starlard-Davenport, Athena, Tryndyak, Volodymyr, Kosyk, Oksana (2010). Acknowledgement to Reveiwers LIFESTYLE GENOMICS. 4-6, 314-314
Hu, Rong, Lam, Wen Jiun, Munday, Karen, Triggs, Christopher M, Zeisel, Steven H, Rahman, Irfan, Chung, Sangwoon, Starlard-Davenport, Athena, Tryndyak, Volodymyr, Kosyk, Oksana (2010). ISNN Society News LIFESTYLE GENOMICS. 4-6, 312-312
Iimuro, Yuji, Bradford, Blair U, Yamashina, Shunhei, Rusyn, Ivan, Nakagami, Mikio, Enomoto, Nobuyuki, Kono, Hiroshi, Frey, William, Forman, Donald, Brenner, David (2000). INFLAMMATION, CYTOKINES, AND FIBROSIS-THE GLUTATHIONE PRECURSOR L-2-OXOTHIAZOLIDINE-4-CARBOXYLIC ACID PROTECTS AGAINST LIVER INJURY DUE TO CHRONIC ENTERAL ETHANOL EXPOSURE IN HEPATOLOGY. 2, 391-398
Zhu, Hao, Ye, Lin, Richard, Ann, Golbraikh, Alexander, Wright, Fred A, Rusyn, Ivan, Tropsha, Alexander (2009). A novel two-step hierarchical quantitative structure–activity relationship modeling work flow for predicting acute toxicity of chemicals in rodents ENVIRONMENTAL HEALTH PERSPECTIVES. 8, 1257-1264
Hammond, Linda E, Albright, Craig D, He, Lihua, Rusyn, Ivan, Watkins, Steven M, Doughman, Scott D, Lemasters, John J, Coleman, Rosalind A (2007). Increased oxidative stress is associated with balanced increases in hepatocyte apoptosis and proliferation in glycerol-3-phosphate acyltransferase-1 deficient mice EXPERIMENTAL AND MOLECULAR PATHOLOGY. 2, 210-219
Gatti, Daniel M, Shabalin, Andrey A, Lam, Tieu-Chong, Wright, Fred A, Rusyn, Ivan, Nobel, Andrew B (2008). FastMap: fast eQTL mapping in homozygous populations BIOINFORMATICS. 4, 482-489
Rodgers, Amie D, Zhu, Hao, Fourches, Denis, Rusyn, Ivan, Tropsha, Alexander (2010). Modeling liver-related adverse effects of drugs using k nearest neighbor quantitative structure− activity relationship method CHEMICAL RESEARCH IN TOXICOLOGY. 4, 724-732
Sedykh, Alexander, Zhu, Hao, Tang, Hao, Zhang, Liying, Richard, Ann, Rusyn, Ivan, Tropsha, Alexander (2010). Use of in vitro HTS-derived concentration–response data as biological descriptors improves the accuracy of QSAR models of in vivo toxicity ENVIRONMENTAL HEALTH PERSPECTIVES. 3, 364-370
Formeister, Eric J, Tsuchiya, Masato, Fujii, Hideki, Shpyleva, Svitlana, Pogribny, Igor P, Rusyn, Ivan (2010). Comparative analysis of promoter methylation and gene expression endpoints between tumorous and non-tumorous tissues from HCV-positive patients with hepatocellular carcinoma MUTATION RESEARCH/FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 1-2, 26-33
Yang, X, Ma, Z, Blackwelder, A, Li, X, Rusyn, I (2013). 628in Utero Exposure To Alcohol Induces Reprogramming Of Mammary Development And Tumor Risk In Mmtv-erbb-2 Transgenic Mice ALCOHOLISM: CLINICAL & EXPERIMENTAL RESEARCH. , 168A
Low, Yen, Sedykh, Alexander, Fourches, Denis, Golbraikh, Alexander, Whelan, Maurice, Rusyn, Ivan, Tropsha, Alexander (2013). Integrative chemical–biological read-across approach for chemical hazard classification CHEMICAL RESEARCH IN TOXICOLOGY. 8, 1199-1208
Rusyn, Ivan, Lemon, Stanley M (2014). Mechanisms of HCV-induced liver cancer: what did we learn from in vitro and animal studies? CANCER LETTERS. 2, 210-215
Rusyn, Ivan (2013). In vitro screening for population variability in chemical toxicity TOXICOLOGY LETTERS. 221, S17-S18
Kushman, Mary E, Kraft, Andrew D, Guyton, Kathryn Z, Chiu, Weihsueh A, Makris, Susan L, Rusyn, Ivan (2013). A systematic approach for identifying and presenting mechanistic evidence in human health assessments REGULATORY TOXICOLOGY AND PHARMACOLOGY. 2, 266-277
Rusyn, Ivan, Chiu, Weihsueh A, Lash, Lawrence H, Kromhout, Hans, Hansen, Johnni, Guyton, Kathryn Z (2014). Trichloroethylene: Mechanistic, epidemiologic and other supporting evidence of carcinogenic hazard PHARMACOLOGY & THERAPEUTICS. 1, 55-68
Sirenko, Oksana, Cromwell, Evan F, Crittenden, Carole, Wignall, Jessica A, Wright, Fred A, Rusyn, Ivan (2013). Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity TOXICOLOGY AND APPLIED PHARMACOLOGY. 3, 500-507
Chappell, Grace, Kutanzi, Kristy, Uehara, Takeki, Tryndyak, Volodymyr, Hong, Hue‐Hua, Hoenerhoff, Mark, Beland, Frederick A, Rusyn, Ivan, Pogribny, Igor P (2014). Genetic and epigenetic changes in fibrosis‐associated hepatocarcinogenesis in mice INTERNATIONAL JOURNAL OF CANCER. 12, 2778-2788
Buck, Lorenna D, Inman, S Walker, Rusyn, Ivan, Griffith, Linda G (2014). Co‐regulation of primary mouse hepatocyte viability and function by oxygen and matrix BIOTECHNOLOGY AND BIOENGINEERING. 5, 1018-1027
Sirenko, Oksana, Hesley, Jayne, Rusyn, Ivan, Cromwell, Evan F (2014). High-content assays for hepatotoxicity using induced pluripotent stem cell–derived cells ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES. 1, 43-54
Wheeler, Michael D, Kono, Hiroshi, Rusyn, Ivan, Arteel, Gavin E, McCarty, Douglas, Samulski, Richard Jude, Thurman, Ronald G (2000). METABOLISM, TRANSPORT, AND GENETIC DISEASES-CHRONIC ETHANOL INCREASES ADEN O-ASSOCIATED VIRAL TRANSGENE EXPRESSION IN RAT LIVER VIA OXIDANT AND NFkB-DEPENDENT MECHANISMS HEPATOLOGY. 5, 1050-1059
Yeatts, Karin, El Sadig, Mohamed, Leith, David, Maskiri, Fatma, Zoubedi, Taoufik, Rusyn, Ivan, Couper, David, Funk, Bill, MacDonald, Jackie, Olshan, Andy (2011). INDOOR AIRPOLLUTANTS ANDRESPIRATORY HEALTH IN THE UNITED ARAB EMIRATES (UAE) ISEE CONFERENCE ABSTRACTS. ,
Cichocki, Joseph A, Luo, Yu-Syuan, Furuya, Shinji, Venkatratnam, Abhishek, Konganti, Kranti, Chiu, Weihsueh A, Threadgill, David W, Pogribny, Igor P, Rusyn, Ivan (2018). Modulation of tetrachloroethylene-associated kidney effects by nonalcoholic fatty liver or steatohepatitis in male C57BL/6J mice TOXICOLOGICAL SCIENCES. 1, 126-137
Rusyn, Ivan, Gatti, Daniel M, Wilshire, Timothy, Kleeberger, Steven R, Threadgill, David W (2010). Toxicogenetics: population-based testing of drug and chemical safety in mouse models PHARMACOGENOMICS. 8, 1127-1136
Uematsu, Fumiyuki, Takahashi, Masakazu, Yoshida, Midori, Igarashi, Maki, Watanabe, Naoto, Suzuki, Noriko, Abe, Masayoshi, Rusyn, Ivan, Floyd, Robert A, Nakae, Dai (2005). Distinct patterns of gene expression in hepatocellular carcinomas and adjacent non‐cancerous, cirrhotic liver tissues in rats fed a choline‐deficient, l‐amino acid‐defined diet CANCER SCIENCE. 7, 414-424
Kono, Hiroshi, Woods, Courtney G, Maki, Akira, Connor, Henry D, Mason, Ronald P, Rusyn, Ivan, Fujii, Hideki (2006). Electron spin resonance and spin trapping technique provide direct evidence that edaravone prevents acute ischemia–reperfusion injury of the liver by limiting free radical-mediated tissue damage FREE RADICAL RESEARCH. 6, 579-588
Gatti, Daniel M, Harrill, Alison H, Wright, Fred A, Threadgill, David W, Rusyn, Ivan (2009). Replication and narrowing of gene expression quantitative trait loci using inbred mice MAMMALIAN GENOME. 7, 437-446
Low, Yen, Uehara, Takeki, Minowa, Yohsuke, Yamada, Hiroshi, Ohno, Yasuo, Urushidani, Tetsuro, Sedykh, Alexander, Muratov, Eugene, Kuz’min, Viktor, Fourches, Denis (2011). Predicting drug-induced hepatotoxicity using QSAR and toxicogenomics approaches CHEMICAL RESEARCH IN TOXICOLOGY. 8, 1251-1262
Luo, Yu-Syuan, Cichocki, Joseph A, McDonald, Thomas J, Rusyn, Ivan (2017). Simultaneous detection of the tetrachloroethylene metabolites S-(1, 2, 2-trichlorovinyl) glutathione, S-(1, 2, 2-trichlorovinyl)-L-cysteine, and N-acetyl-S-(1, 2, 2-trichlorovinyl)-L-cysteine in multiple mouse tissues via ultra-high performance liquid chromatography electrospray ionization tandem mass spectrometry JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, PART A. 9, 513-524
Wheeler, MD (2001). Kono H, Yin M, Nakagami M, Uesugi T, Arteel GE, Gabele E, Rusyn I, Yamashina S, Froh M, Adachi Y, Iimuro Y, Bradford BU, Smutney OM, Connor HD, Mason RP, Goyert SM, Peters JM, Gonzalez FJ, Samulski RJ, and Thurman RG THE ROLE OF KUPFFER CELL OXIDANT PRODUCTION IN EARLY ETHANOL-INDUCED LIVER DISEASE. FREE RADIC BIOL MED. , 1544-1549
Chiu, Weihsueh A, Campbell Jr, Jerry L, Clewell III, Harvey J, Zhou, Yi-Hui, Wright, Fred A, Guyton, Kathryn Z, Rusyn, Ivan (2014). Physiologically based pharmacokinetic (PBPK) modeling of interstrain variability in trichloroethylene metabolism in the mouse ENVIRONMENTAL HEALTH PERSPECTIVES. 5, 456-463
Wignall, Jessica A, Shapiro, Andrew J, Wright, Fred A, Woodruff, Tracey J, Chiu, Weihsueh A, Guyton, Kathryn Z, Rusyn, Ivan (2014). Standardizing benchmark dose calculations to improve science-based decisions in human health assessments ENVIRONMENTAL HEALTH PERSPECTIVES. 5, 499-505
Rusyn, Ivan, Bataller, Ramon (2013). Autophagy: one of the molecular mechanisms of response to intra-cellular stress in alcohol toxicity JOURNAL OF HEPATOLOGY. 2, 399
Odena, G, Morales-Ibanez, O, Affo, S, Furuya, S, Rusyn, I, Altamirano, J, Sancho-Bru, P, Arroyo, V, Gines, P, Caballeria, J (2014). P344 TRANSLATIONAL STUDY IDENTIFIES NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (NGAL) AS A POTENTIAL MEDIATOR OF LIVER INJURY AND FIBROGENESIS IN ALCOHOLIC HEPATITIS JOURNAL OF HEPATOLOGY. 1, S181-S182
Furuya, S, Kosyk, O, Uehara, T, Odena, G, Kato, Y, Kono, H, Bataller, R, Rusyn, I (2014). P307 ACUTE-ON-CHRONIC MODEL OF ALCOHOLIC HEPATITIS IN THE MOUSE JOURNAL OF HEPATOLOGY. 1, S168
Lash, Lawrence H, Chiu, Weihsueh A, Guyton, Kathryn Z, Rusyn, Ivan (2014). Trichloroethylene biotransformation and its role in mutagenicity, carcinogenicity and target organ toxicity MUTATION RESEARCH/REVIEWS IN MUTATION RESEARCH. , 22-36
Maras, JS, Das, S, Jaswal, SS, Mahiwal, R, Kumar, C, Kumar, D, Gawda, HHC, Rastogi, A, Pati, NT, Sharma, S (2014). P339 PON1 DIRECTED RECALIBRATION OF MACROPHAGE LIPID HOMEOSTASIS LEADS TO REVERSAL OF CIRCULATING FOAMY PHENOTYPE AND PREDICTS OUTCOME IN ACUTE ON CHRONIC LIVER FAILURE (ACLF) PATIENTS JOURNAL OF HEPATOLOGY. 1, S180
Sia Low, Yen, Yeugenyevich Sedykh, Alexander, Rusyn, Ivan, Tropsha, Alexander (2014). Integrative approaches for predicting in vivo effects of chemicals from their structural descriptors and the results of short-term biological assays CURRENT TOPICS IN MEDICINAL CHEMISTRY. 11, 1356-1364
Woods, Courtney G, Kosyk, Oksana, Bradford, Blair U, Ross, Pamela K, Burns, Amanda M, Cunningham, Michael L, Qu, Pingping, Ibrahim, Joseph G, Rusyn, Ivan (2007). Time course investigation of PPARα-and Kupffer cell-dependent effects of WY-14,643 in mouse liver using microarray gene expression TOXICOLOGY AND APPLIED PHARMACOLOGY. 3, 267-277
Rusyn, Ivan, Fry, Rebecca C, Begley, Thomas J, Klapacz, Joanna, Svensson, J Peter, Ambrose, Mark, Samson, Leona D (2007). Transcriptional networks in S. cerevisiae linked to an accumulation of base excision repair intermediates PLOS ONE. 11, e1252
Yin, Ming, Rusyn, Ivan, Schoonhoven, Robert, Graves, Lee M, Rusyn, Elena V, Li, Xiangli, Li, Fengling, Cox, Adrienne D, Harding, Tim W, Bunzendahl, Hartwig (2000). Inhibition of chronic rejection of aortic allografts by dietary glycine TRANSPLANTATION. 5, 773-781
Ross, Pamela K, Woods, Courtney G, Bradford, Blair U, Kosyk, Oksana, Gatti, Daniel M, Cunningham, Michael L, Rusyn, Ivan (2009). Time-course comparison of xenobiotic activators of CAR and PPARα in mouse liver TOXICOLOGY AND APPLIED PHARMACOLOGY. 2, 199-207
O'Shea, Shannon H, Schwarz, John, Kosyk, Oksana, Ross, Pamela K, Ha, Min Jin, Wright, Fred A, Rusyn, Ivan (2010). In vitro screening for population variability in chemical toxicity TOXICOLOGICAL SCIENCES. 2, 398-407
Kim, Sungkyoon, Kim, David, Pollack, Gary M, Collins, Leonard B, Rusyn, Ivan (2009). Pharmacokinetic analysis of trichloroethylene metabolism in male B6C3F1 mice: Formation and disposition of trichloroacetic acid, dichloroacetic acid, S-(1, 2-dichlorovinyl) glutathione and S-(1, 2-dichlorovinyl)-L-cysteine TOXICOLOGY AND APPLIED PHARMACOLOGY. 1, 90-99
Powell, Christine L, Bradford, Blair U, Craig, Christopher Patrick, Tsuchiya, Masato, Uehara, Takeki, O’Connell, Thomas M, Pogribny, Igor P, Melnyk, Stepan, Koop, Dennis R, Bleyle, Lisa (2010). Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors TOXICOLOGICAL SCIENCES. 1, 131-139
Kim, Sungkyoon, Collins, Leonard B, Boysen, Gunnar, Swenberg, James A, Gold, Avram, Ball, Louise M, Bradford, Blair U, Rusyn, Ivan (2009). Liquid chromatography electrospray ionization tandem mass spectrometry analysis method for simultaneous detection of trichloroacetic acid, dichloroacetic acid, S-(1, 2-dichlorovinyl) glutathione and S-(1, 2-dichlorovinyl)-L-cysteine TOXICOLOGY. 3, 230-238
